Chlorine in PDB 3uon: Structure of the Human M2 Muscarinic Acetylcholine Receptor Bound to An Antagonist

All present enzymatic activity of Structure of the Human M2 Muscarinic Acetylcholine Receptor Bound to An Antagonist:
3.2.1.17;

The structure of Structure of the Human M2 Muscarinic Acetylcholine Receptor Bound to An Antagonist, PDB code: 3uon was solved by K.Haga, A.C.Kruse, H.Asada, T.Yurugi-Kobayashi, M.Shiroishi, C.Zhang, W.I.Weis, T.Okada, B.K.Kobilka, T.Haga, T.Kobayashi, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	27.47 / 3.00
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	78.170, 47.260, 88.120, 90.00, 109.70, 90.00
R / Rfree (%)	22.5 / 27.6

The binding sites of Chlorine atom in the Structure of the Human M2 Muscarinic Acetylcholine Receptor Bound to An Antagonist (pdb code 3uon). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Structure of the Human M2 Muscarinic Acetylcholine Receptor Bound to An Antagonist, PDB code: 3uon:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Structure of the Human M2 Muscarinic Acetylcholine Receptor Bound to An Antagonist


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of the Human M2 Muscarinic Acetylcholine Receptor Bound to An Antagonist within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1164 b:51.4 occ:1.00 NH2 A:ARG381 3.0 59.6 1.0 O A:HOH1179 3.6 44.5 1.0 CG A:LYS384 3.7 58.4 1.0 NZ A:LYS1060 3.9 65.8 1.0 N A:LYS384 4.1 56.5 1.0 CD A:LYS384 4.1 52.6 1.0 CE A:LYS1060 4.2 58.6 1.0 CE A:LYS384 4.3 53.6 1.0 CB A:LYS384 4.3 50.2 1.0 CZ A:ARG381 4.4 72.4 1.0 CD A:LYS1060 4.8 51.7 1.0 CA A:LYS383 4.8 60.0 1.0 CA A:LYS384 4.8 53.8 1.0 C A:LYS383 4.9 63.1 1.0

Chlorine binding site 2 out of 2 in the Structure of the Human M2 Muscarinic Acetylcholine Receptor Bound to An Antagonist


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Structure of the Human M2 Muscarinic Acetylcholine Receptor Bound to An Antagonist within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1165 b:50.1 occ:1.00 NZ A:LYS1065 3.2 66.6 1.0 OG1 A:THR137 3.4 55.0 1.0 N A:THR137 3.5 53.5 1.0 CE A:LYS1065 3.6 68.3 1.0 CB A:THR136 3.7 57.6 1.0 CG2 A:THR137 3.9 53.2 1.0 CA A:THR136 4.1 62.0 1.0 CB A:THR137 4.1 53.8 1.0 C A:THR136 4.3 55.1 1.0 CG2 A:THR136 4.3 48.8 1.0 CA A:THR137 4.4 54.3 1.0 OG1 A:THR136 4.8 54.0 1.0 CD A:LYS1065 4.9 71.6 1.0

K.Haga, A.C.Kruse, H.Asada, T.Yurugi-Kobayashi, M.Shiroishi, C.Zhang, W.I.Weis, T.Okada, B.K.Kobilka, T.Haga, T.Kobayashi. Structure of the Human M2 Muscarinic Acetylcholine Receptor Bound to An Antagonist. Nature V. 482 547 2012.
ISSN: ISSN 0028-0836
PubMed: 22278061
DOI: 10.1038/NATURE10753