Chlorine in PDB 3v72: Crystal Structure of Rat Dna Polymerase Beta Mutator E295K: Enzyme- Dsdna

All present enzymatic activity of Crystal Structure of Rat Dna Polymerase Beta Mutator E295K: Enzyme- Dsdna:
2.7.7.7;

The structure of Crystal Structure of Rat Dna Polymerase Beta Mutator E295K: Enzyme- Dsdna, PDB code: 3v72 was solved by C.L.Gridley, J.Jaeger, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	24.76 / 2.49
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	57.193, 73.763, 118.367, 90.00, 90.00, 90.00
R / Rfree (%)	21.8 / 29.1

The structure of Crystal Structure of Rat Dna Polymerase Beta Mutator E295K: Enzyme- Dsdna also contains other interesting chemical elements:

Sodium

(Na)

2 atoms

The binding sites of Chlorine atom in the Crystal Structure of Rat Dna Polymerase Beta Mutator E295K: Enzyme- Dsdna (pdb code 3v72). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Rat Dna Polymerase Beta Mutator E295K: Enzyme- Dsdna, PDB code: 3v72:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Crystal Structure of Rat Dna Polymerase Beta Mutator E295K: Enzyme- Dsdna


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Rat Dna Polymerase Beta Mutator E295K: Enzyme- Dsdna within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl403 b:87.3 occ:1.00 O A:HOH514 2.6 34.2 1.0 O A:LYS131 5.0 38.0 1.0

Chlorine binding site 2 out of 2 in the Crystal Structure of Rat Dna Polymerase Beta Mutator E295K: Enzyme- Dsdna


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Rat Dna Polymerase Beta Mutator E295K: Enzyme- Dsdna within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl404 b:89.0 occ:1.00 ND1 A:HIS34 2.5 50.0 1.0 ND2 A:ASN37 3.1 39.0 1.0 CE1 A:HIS34 3.3 42.8 1.0 CG A:HIS34 3.5 47.3 1.0 CA A:HIS34 3.7 51.2 1.0 CB A:ASN37 3.8 43.7 1.0 CB A:HIS34 3.9 54.8 1.0 CG A:ASN37 3.9 40.5 1.0 NE2 A:HIS34 4.5 43.7 1.0 O A:HIS34 4.5 32.6 1.0 O A:ILE33 4.6 42.4 1.0 N A:HIS34 4.6 49.4 1.0 CD2 A:HIS34 4.6 38.9 1.0 C A:HIS34 4.6 36.2 1.0 C A:ILE33 4.9 43.7 1.0

Y.Li, C.L.Gridley, J.Jaeger, J.B.Sweasy, T.Schlick. Unfavorable Electrostatic and Steric Interactions in Dna Polymerase Beta E295K Mutant Interfere with the Enzyme S Pathway J.Am.Chem.Soc. V. 134 9999 2012.
ISSN: ISSN 0002-7863
PubMed: 22651551
DOI: 10.1021/JA300361R