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Atomistry » Chlorine » PDB 3wnr-3x1u » 3wzk » |
Chlorine in PDB 3wzk: Crystal Structure of Human MPS1 Catalytic Domain in Complex with N- Cyclopropyl-4-(8-((Thiophen-2-Ylmethyl)Amino)Imidazo[1,2-A]Pyrazin-3- Yl)BenzamideEnzymatic activity of Crystal Structure of Human MPS1 Catalytic Domain in Complex with N- Cyclopropyl-4-(8-((Thiophen-2-Ylmethyl)Amino)Imidazo[1,2-A]Pyrazin-3- Yl)Benzamide
All present enzymatic activity of Crystal Structure of Human MPS1 Catalytic Domain in Complex with N- Cyclopropyl-4-(8-((Thiophen-2-Ylmethyl)Amino)Imidazo[1,2-A]Pyrazin-3- Yl)Benzamide:
2.7.12.1; Protein crystallography data
The structure of Crystal Structure of Human MPS1 Catalytic Domain in Complex with N- Cyclopropyl-4-(8-((Thiophen-2-Ylmethyl)Amino)Imidazo[1,2-A]Pyrazin-3- Yl)Benzamide, PDB code: 3wzk
was solved by
K.Kusakabe,
N.Ide,
Y.Daigo,
T.Itoh,
T.Yamamoto,
E.Kojima,
Y.Mitsuoka,
G.Tadano,
S.Tagashira,
K.Higashino,
Y.Okano,
Y.Sato,
M.Inoue,
M.Iguchi,
T.Kanazawa,
Y.Ishioka,
K.Dohi,
Y.Kido,
S.Sakamoto,
S.Ando,
M.Maeda,
M.Higaki,
H.Yoshizawa,
H.Mura,
Y.Nakamura,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Human MPS1 Catalytic Domain in Complex with N- Cyclopropyl-4-(8-((Thiophen-2-Ylmethyl)Amino)Imidazo[1,2-A]Pyrazin-3- Yl)Benzamide
(pdb code 3wzk). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Human MPS1 Catalytic Domain in Complex with N- Cyclopropyl-4-(8-((Thiophen-2-Ylmethyl)Amino)Imidazo[1,2-A]Pyrazin-3- Yl)Benzamide, PDB code: 3wzk: Chlorine binding site 1 out of 1 in 3wzkGo back to Chlorine Binding Sites List in 3wzk
Chlorine binding site 1 out
of 1 in the Crystal Structure of Human MPS1 Catalytic Domain in Complex with N- Cyclopropyl-4-(8-((Thiophen-2-Ylmethyl)Amino)Imidazo[1,2-A]Pyrazin-3- Yl)Benzamide
Mono view Stereo pair view
Reference:
K.I.Kusakabe,
N.Ide,
Y.Daigo,
T.Itoh,
T.Yamamoto,
H.Hashizume,
K.Nozu,
H.Yoshida,
G.Tadano,
S.Tagashira,
K.Higashino,
Y.Okano,
Y.Sato,
M.Inoue,
M.Iguchi,
T.Kanazawa,
Y.Ishioka,
K.Dohi,
Y.Kido,
S.Sakamoto,
S.Ando,
M.Maeda,
M.Higaki,
Y.Baba,
Y.Nakamura.
Discovery of Imidazo[1,2-B]Pyridazine Derivatives: Selective and Orally Available MPS1 (Ttk) Kinase Inhibitors Exhibiting Remarkable Antiproliferative Activity J.Med.Chem. 2015.
Page generated: Sat Dec 12 10:20:11 2020
ISSN: ISSN 0022-2623 PubMed: 25625617 DOI: 10.1021/JM501599U |
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