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Chlorine in PDB 3zzh: Crystal Structure of the Amino Acid Kinase Domain From Saccharomyces Cerevisiae Acetylglutamate Kinase in Complex with Its Feed-Back Inhibitor L-Arginine

Enzymatic activity of Crystal Structure of the Amino Acid Kinase Domain From Saccharomyces Cerevisiae Acetylglutamate Kinase in Complex with Its Feed-Back Inhibitor L-Arginine

All present enzymatic activity of Crystal Structure of the Amino Acid Kinase Domain From Saccharomyces Cerevisiae Acetylglutamate Kinase in Complex with Its Feed-Back Inhibitor L-Arginine:
2.7.2.8;

Protein crystallography data

The structure of Crystal Structure of the Amino Acid Kinase Domain From Saccharomyces Cerevisiae Acetylglutamate Kinase in Complex with Its Feed-Back Inhibitor L-Arginine, PDB code: 3zzh was solved by S.De Cima, F.Gil-Ortiz, M.Crabeel, I.Fita, V.Rubio, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 20.00 / 2.10
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 69.489, 99.596, 189.238, 90.00, 90.00, 90.00
R / Rfree (%) 18.037 / 21.544

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of the Amino Acid Kinase Domain From Saccharomyces Cerevisiae Acetylglutamate Kinase in Complex with Its Feed-Back Inhibitor L-Arginine (pdb code 3zzh). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 5 binding sites of Chlorine where determined in the Crystal Structure of the Amino Acid Kinase Domain From Saccharomyces Cerevisiae Acetylglutamate Kinase in Complex with Its Feed-Back Inhibitor L-Arginine, PDB code: 3zzh:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5;

Chlorine binding site 1 out of 5 in 3zzh

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Chlorine binding site 1 out of 5 in the Crystal Structure of the Amino Acid Kinase Domain From Saccharomyces Cerevisiae Acetylglutamate Kinase in Complex with Its Feed-Back Inhibitor L-Arginine


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of the Amino Acid Kinase Domain From Saccharomyces Cerevisiae Acetylglutamate Kinase in Complex with Its Feed-Back Inhibitor L-Arginine within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1359

b:25.9
occ:1.00
 NZ A:LYS283 3.0 16.9 1.0
O A:HOH2120 3.3 6.5 1.0
O A:GLY273 3.5 14.2 1.0
N A:GLY345 3.5 21.6 1.0
CA A:GLY345 4.0 19.7 1.0
C A:GLY273 4.3 13.2 1.0
CA A:GLY273 4.3 14.0 1.0
CE A:LYS283 4.4 17.0 1.0
C A:ALA344 4.5 23.3 1.0
CA A:ALA344 4.6 25.8 1.0
OD2 A:ASP333 4.6 24.2 1.0
CG A:LYS283 4.6 16.4 1.0
O A:LYS272 4.7 15.6 1.0
CB A:ALA344 4.7 26.0 1.0
O A:HOH2123 4.8 2.9 1.0
CD A:LYS283 4.8 16.1 1.0

Chlorine binding site 2 out of 5 in 3zzh

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Chlorine binding site 2 out of 5 in the Crystal Structure of the Amino Acid Kinase Domain From Saccharomyces Cerevisiae Acetylglutamate Kinase in Complex with Its Feed-Back Inhibitor L-Arginine


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of the Amino Acid Kinase Domain From Saccharomyces Cerevisiae Acetylglutamate Kinase in Complex with Its Feed-Back Inhibitor L-Arginine within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl1367

b:21.2
occ:1.00
 O B:HOH2040 2.9 4.2 1.0
O B:HOH2142 3.0 11.6 1.0
N B:GLU271 3.4 11.4 1.0
CA B:ASN270 3.6 10.2 1.0
CG B:GLU271 3.7 12.7 1.0
CB B:ASN270 3.8 10.7 1.0
O B:HOH2110 3.9 8.7 1.0
C B:ASN270 4.0 10.7 1.0
CB B:ALA107 4.0 9.8 1.0
CA B:GLY105 4.2 9.3 1.0
CB B:GLU271 4.2 12.7 1.0
CG1 B:ILE108 4.3 9.7 1.0
CA B:GLU271 4.4 12.2 1.0
CD B:GLU271 4.4 14.0 1.0
O B:LEU269 4.5 9.1 1.0
O B:HOH2037 4.6 7.2 1.0
C B:GLY105 4.6 9.0 1.0
CD1 B:ILE108 4.7 10.3 1.0
N B:ALA107 4.7 9.1 1.0
OE1 B:GLU271 4.8 15.7 1.0
N B:ILE108 4.8 9.0 1.0
C2 B:EDO1364 4.8 32.7 1.0
O2 B:EDO1364 4.8 32.9 1.0
CA B:ALA107 4.8 9.4 1.0
O B:GLY105 4.8 8.6 1.0
N B:ASN270 4.8 9.7 1.0
O B:HOH2141 4.9 26.5 1.0
C2 B:EDO1359 4.9 39.3 1.0
O2 B:EDO1359 4.9 39.0 1.0
OE2 B:GLU271 5.0 14.0 1.0

Chlorine binding site 3 out of 5 in 3zzh

Go back to Chlorine Binding Sites List in 3zzh
Chlorine binding site 3 out of 5 in the Crystal Structure of the Amino Acid Kinase Domain From Saccharomyces Cerevisiae Acetylglutamate Kinase in Complex with Its Feed-Back Inhibitor L-Arginine


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of the Amino Acid Kinase Domain From Saccharomyces Cerevisiae Acetylglutamate Kinase in Complex with Its Feed-Back Inhibitor L-Arginine within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl1360

b:36.9
occ:1.00
 ND2 C:ASN141 3.0 13.8 1.0
CA C:PRO138 3.8 14.1 1.0
CG C:ASN141 4.0 14.0 1.0
CB C:ASN141 4.1 14.2 1.0
CB C:PRO138 4.1 14.5 1.0
CG C:PRO138 4.5 14.5 1.0
N C:PRO138 4.5 13.4 1.0
O C:PRO138 4.6 13.7 1.0
C C:PRO138 4.7 13.7 1.0
O C:GLY137 4.8 13.6 1.0
C C:GLY137 5.0 13.1 1.0

Chlorine binding site 4 out of 5 in 3zzh

Go back to Chlorine Binding Sites List in 3zzh
Chlorine binding site 4 out of 5 in the Crystal Structure of the Amino Acid Kinase Domain From Saccharomyces Cerevisiae Acetylglutamate Kinase in Complex with Its Feed-Back Inhibitor L-Arginine


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Crystal Structure of the Amino Acid Kinase Domain From Saccharomyces Cerevisiae Acetylglutamate Kinase in Complex with Its Feed-Back Inhibitor L-Arginine within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cl1367

b:19.2
occ:1.00
 O D:HOH2137 2.9 16.1 1.0
O D:HOH2030 2.9 3.8 1.0
O D:HOH2106 3.1 21.5 1.0
N D:GLU271 3.4 11.4 1.0
CA D:ASN270 3.6 10.2 1.0
CG D:GLU271 3.7 13.7 1.0
CB D:ASN270 3.8 10.6 1.0
O D:HOH2103 3.9 8.0 1.0
C D:ASN270 3.9 10.5 1.0
CA D:GLY105 4.0 8.9 1.0
CB D:ALA107 4.1 9.9 1.0
CB D:GLU271 4.2 12.7 1.0
O D:HOH2029 4.3 4.7 1.0
CG1 D:ILE108 4.3 8.8 1.0
CA D:GLU271 4.4 12.4 1.0
CD1 D:ILE108 4.4 8.9 1.0
CD D:GLU271 4.5 15.4 1.0
C D:GLY105 4.5 8.8 1.0
O D:LEU269 4.5 9.4 1.0
O D:HOH2138 4.5 30.9 1.0
N D:ALA107 4.7 9.1 1.0
O D:GLY105 4.7 8.8 1.0
N D:ILE108 4.8 8.9 1.0
O D:HOH2101 4.8 18.6 1.0
N D:ASN270 4.8 9.8 1.0
CA D:ALA107 4.9 9.6 1.0
C1 D:EDO1364 4.9 35.5 1.0
OE1 D:GLU271 4.9 17.0 1.0
N D:GLY105 4.9 8.8 1.0

Chlorine binding site 5 out of 5 in 3zzh

Go back to Chlorine Binding Sites List in 3zzh
Chlorine binding site 5 out of 5 in the Crystal Structure of the Amino Acid Kinase Domain From Saccharomyces Cerevisiae Acetylglutamate Kinase in Complex with Its Feed-Back Inhibitor L-Arginine


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Crystal Structure of the Amino Acid Kinase Domain From Saccharomyces Cerevisiae Acetylglutamate Kinase in Complex with Its Feed-Back Inhibitor L-Arginine within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cl1368

b:29.2
occ:1.00
 O D:HOH2068 3.2 20.2 1.0
NH2 D:ARG169 3.2 14.2 1.0
OG C:SER195 3.2 15.1 1.0
NE D:ARG169 3.5 14.2 1.0
CE D:MET245 3.6 21.8 1.0
CZ D:ARG169 3.8 14.8 1.0
N C:GLY196 3.8 14.9 1.0
CB C:SER195 3.8 15.0 1.0
CA C:GLY196 3.9 14.9 1.0
SD D:MET245 3.9 20.8 1.0
C C:SER195 4.3 14.6 1.0
O D:HOH2079 4.3 15.3 1.0
CB D:ARG169 4.7 11.8 1.0
CD D:ARG169 4.7 13.4 1.0
CA C:SER195 4.7 14.3 1.0
CG D:ARG169 4.8 12.2 1.0
O C:SER195 4.9 14.8 1.0

Reference:

S.De Cima, F.Gil-Ortiz, M.Crabeel, I.Fita, V.Rubio. Insight on An Arginine Synthesis Metabolon From the Tetrameric Structure of Yeast Acetylglutamate Kinase Plos One V. 7 34734 2012.
ISSN: ISSN 1932-6203
PubMed: 22529931
DOI: 10.1371/JOURNAL.PONE.0034734
Page generated: Sun Jul 21 08:41:05 2024

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