Chlorine in PDB 4amp: Crystal Structure of the Acyltransferase Domain of the Iterative Polyketide Synthase in Enediyne Biosynthesis Reveals the Molecular Basis of Substrate Specificity

The structure of Crystal Structure of the Acyltransferase Domain of the Iterative Polyketide Synthase in Enediyne Biosynthesis Reveals the Molecular Basis of Substrate Specificity, PDB code: 4amp was solved by C.W.Liew, J.Lescar, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	52.50 / 1.65
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	65.714, 66.245, 86.086, 90.00, 90.00, 90.00
R / Rfree (%)	17.352 / 21.335

The binding sites of Chlorine atom in the Crystal Structure of the Acyltransferase Domain of the Iterative Polyketide Synthase in Enediyne Biosynthesis Reveals the Molecular Basis of Substrate Specificity (pdb code 4amp). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of the Acyltransferase Domain of the Iterative Polyketide Synthase in Enediyne Biosynthesis Reveals the Molecular Basis of Substrate Specificity, PDB code: 4amp:

Chlorine binding site 1 out of 1 in the Crystal Structure of the Acyltransferase Domain of the Iterative Polyketide Synthase in Enediyne Biosynthesis Reveals the Molecular Basis of Substrate Specificity


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of the Acyltransferase Domain of the Iterative Polyketide Synthase in Enediyne Biosynthesis Reveals the Molecular Basis of Substrate Specificity within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1877 b:29.0 occ:1.00 NH2 A:ARG639 3.2 21.1 0.5 CG A:PRO871 3.4 17.3 1.0 NE A:ARG639 3.4 20.9 0.5 CB A:PRO871 3.7 17.6 1.0 CZ A:ARG639 3.8 22.1 0.5 CA A:PRO871 3.9 17.4 1.0 CD A:PRO871 4.1 14.5 1.0 N A:PRO871 4.2 14.1 1.0 OG1 A:THR870 4.4 13.5 1.0 CG A:ARG639 4.6 13.3 0.5 CD A:ARG639 4.6 22.5 0.5 CG A:ARG639 4.7 18.9 0.5 CD A:ARG639 4.8 18.3 0.5 C A:THR870 4.9 15.2 1.0

C.W.Liew, M.Nilsson, M.W.Chen, H.Sun, T.Cornvik, Z.Liang, J.Lescar. Crystal Structure of the Acyltransferase Domain of the Iterative Polyketide Synthase in Enediyne Biosynthesis. J.Biol.Chem. V. 287 23203 2012.
ISSN: ISSN 0021-9258
PubMed: 22589546
DOI: 10.1074/JBC.M112.362210