Chlorine in PDB 4aqa: Crystal Structure of Deafness Associated Mutant Mouse Cadherin-23 EC1-2D124G and Protocadherin-15 EC1-2 Form I

The structure of Crystal Structure of Deafness Associated Mutant Mouse Cadherin-23 EC1-2D124G and Protocadherin-15 EC1-2 Form I, PDB code: 4aqa was solved by M.Sotomayor, W.Weihofen, R.Gaudet, D.P.Corey, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	34.19 / 1.96
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	173.293, 40.506, 84.629, 90.00, 102.86, 90.00
R / Rfree (%)	17.782 / 22.775

The structure of Crystal Structure of Deafness Associated Mutant Mouse Cadherin-23 EC1-2D124G and Protocadherin-15 EC1-2 Form I also contains other interesting chemical elements:

Potassium	(K)	1 atom
Calcium	(Ca)	7 atoms

The binding sites of Chlorine atom in the Crystal Structure of Deafness Associated Mutant Mouse Cadherin-23 EC1-2D124G and Protocadherin-15 EC1-2 Form I (pdb code 4aqa). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Deafness Associated Mutant Mouse Cadherin-23 EC1-2D124G and Protocadherin-15 EC1-2 Form I, PDB code: 4aqa:

Chlorine binding site 1 out of 1 in the Crystal Structure of Deafness Associated Mutant Mouse Cadherin-23 EC1-2D124G and Protocadherin-15 EC1-2 Form I


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Deafness Associated Mutant Mouse Cadherin-23 EC1-2D124G and Protocadherin-15 EC1-2 Form I within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1212 b:18.3 occ:1.00 CA A:CA1210 2.8 19.8 1.0 O A:VAL103 3.2 15.1 1.0 N A:LEU139 3.2 13.2 1.0 O A:HOH2226 3.4 12.7 1.0 OE2 A:GLU74 3.4 22.1 1.0 NE A:ARG73 3.4 22.1 1.0 CA A:GLY102 3.5 16.4 1.0 N A:VAL103 3.5 16.3 1.0 OE2 A:GLU22 3.7 19.6 1.0 C A:GLY102 3.7 16.4 1.0 C A:VAL103 3.8 15.3 1.0 CB A:LEU139 3.8 14.2 1.0 CB A:ASP138 3.9 12.6 1.0 CA A:ASP138 3.9 12.9 1.0 CD A:ARG73 3.9 22.1 1.0 OD1 A:ASP138 3.9 13.3 1.0 CG A:LEU139 4.0 14.7 1.0 C A:ASP138 4.0 13.0 1.0 CA A:LEU139 4.1 13.6 1.0 CA A:VAL103 4.2 15.8 1.0 CZ A:ARG73 4.3 22.6 1.0 CG A:ASP138 4.4 12.9 1.0 CG B:PRO19 4.4 15.1 1.0 NH2 A:ARG73 4.4 22.6 1.0 CD A:GLU74 4.5 23.1 1.0 CD1 A:LEU139 4.6 15.3 1.0 N A:ASN104 4.6 15.0 1.0 O A:GLY102 4.7 17.7 1.0 O A:LEU139 4.8 13.2 1.0 N A:GLY102 4.8 16.8 1.0 OE1 A:GLU74 4.9 21.7 1.0 CD A:GLU22 4.9 19.5 1.0 C A:LEU139 5.0 13.4 1.0 CA A:ASN104 5.0 14.6 1.0

M.Sotomayor, W.Weihofen, R.Gaudet, D.P.Corey. Structure of A Force-Conveying Cadherin Bond Essential For Inner-Ear Mechanotransduction Nature V. 492 128 2012.
ISSN: ISSN 0028-0836
PubMed: 23135401
DOI: 10.1038/NATURE11590