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Chlorine in PDB 4b3o: Structures of Hiv-1 Rt and Rna-Dna Complex Reveal A Unique Rt Conformation and Substrate Interface

Enzymatic activity of Structures of Hiv-1 Rt and Rna-Dna Complex Reveal A Unique Rt Conformation and Substrate Interface

All present enzymatic activity of Structures of Hiv-1 Rt and Rna-Dna Complex Reveal A Unique Rt Conformation and Substrate Interface:
2.7.7.49; 2.7.7.7; 3.1.13.2; 3.1.26.13; 3.4.23.16;

Protein crystallography data

The structure of Structures of Hiv-1 Rt and Rna-Dna Complex Reveal A Unique Rt Conformation and Substrate Interface, PDB code: 4b3o was solved by M.Lapkouski, L.Tian, J.T.Miller, S.F.J.Le Grice, W.Yang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 29.73 / 3.30
Space group P 31 2 1
Cell size a, b, c (Å), α, β, γ (°) 164.598, 164.598, 129.030, 90.00, 90.00, 120.00
R / Rfree (%) 27.5 / 29.5

Other elements in 4b3o:

The structure of Structures of Hiv-1 Rt and Rna-Dna Complex Reveal A Unique Rt Conformation and Substrate Interface also contains other interesting chemical elements:

Fluorine (F) 3 atoms
Calcium (Ca) 2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Structures of Hiv-1 Rt and Rna-Dna Complex Reveal A Unique Rt Conformation and Substrate Interface (pdb code 4b3o). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Structures of Hiv-1 Rt and Rna-Dna Complex Reveal A Unique Rt Conformation and Substrate Interface, PDB code: 4b3o:

Chlorine binding site 1 out of 1 in 4b3o

Go back to Chlorine Binding Sites List in 4b3o
Chlorine binding site 1 out of 1 in the Structures of Hiv-1 Rt and Rna-Dna Complex Reveal A Unique Rt Conformation and Substrate Interface


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structures of Hiv-1 Rt and Rna-Dna Complex Reveal A Unique Rt Conformation and Substrate Interface within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1557

b:64.7
occ:1.00
CL A:EFZ1557 0.0 64.7 1.0
C4 A:EFZ1557 1.7 77.4 1.0
C3 A:EFZ1557 2.6 73.3 1.0
C5 A:EFZ1557 2.7 67.4 1.0
CG1 A:VAL106 3.6 72.4 1.0
CD2 A:PHE227 3.7 79.9 1.0
CE2 A:PHE227 3.8 77.8 1.0
CB A:LEU234 3.8 77.1 1.0
CG2 A:VAL106 3.9 60.4 1.0
C2 A:EFZ1557 3.9 69.2 1.0
C6 A:EFZ1557 4.0 69.0 1.0
O A:HIS235 4.0 77.3 1.0
CB A:VAL106 4.1 59.1 1.0
C A:HIS235 4.3 71.7 1.0
OH A:TYR318 4.4 69.5 1.0
C1 A:EFZ1557 4.4 68.2 1.0
F1 A:EFZ1557 4.4 69.1 1.0
CD1 A:LEU234 4.5 70.5 1.0
N A:HIS235 4.5 74.6 1.0
CG A:LEU234 4.6 75.3 1.0
C A:LEU234 4.6 79.4 1.0
N A:PRO236 4.7 72.4 1.0
CA A:HIS235 4.8 71.4 1.0
CD2 A:LEU234 4.8 74.2 1.0
CA A:LEU234 4.9 76.6 1.0
CG A:PHE227 4.9 77.7 1.0
CA A:PRO236 4.9 73.8 1.0

Reference:

M.Lapkouski, L.Tian, J.T.Miller, S.F.J.Le Grice, W.Yang. Complexes of Hiv-1 Rt, Nnrti and Rna/Dna Hybrid Reveal A Structure Compatible with Rna Degradation Nat.Struct.Mol.Biol. V. 20 230 2013.
ISSN: ISSN 1545-9993
PubMed: 23314251
DOI: 10.1038/NSMB.2485
Page generated: Sun Jul 21 09:40:44 2024

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