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Chlorine in PDB 4bel: BACE2 Xaperone Complex

Enzymatic activity of BACE2 Xaperone Complex

All present enzymatic activity of BACE2 Xaperone Complex:
3.4.23.45;

Protein crystallography data

The structure of BACE2 Xaperone Complex, PDB code: 4bel was solved by D.W.Banner, A.Kuglstatter, J.Benz, M.Stihle, A.Ruf, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 43.68 / 1.85
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 63.027, 61.757, 115.620, 90.00, 101.38, 90.00
R / Rfree (%) 18.13 / 22.234

Chlorine Binding Sites:

The binding sites of Chlorine atom in the BACE2 Xaperone Complex (pdb code 4bel). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the BACE2 Xaperone Complex, PDB code: 4bel:

Chlorine binding site 1 out of 1 in 4bel

Go back to Chlorine Binding Sites List in 4bel
Chlorine binding site 1 out of 1 in the BACE2 Xaperone Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of BACE2 Xaperone Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1398

b:21.2
occ:1.00
O A:HOH2105 3.1 28.3 1.0
ND2 A:ASN114 3.1 18.3 1.0
N D:ILE192 3.2 19.4 1.0
O A:HOH2112 3.3 17.4 0.5
NZ A:LYS79 3.4 23.8 1.0
N A:GLU150 3.5 20.9 1.0
O A:SER148 3.6 24.5 0.5
O A:SER148 3.6 25.0 0.5
CA D:ALA191 3.6 20.0 1.0
OD1 A:ASN114 3.9 20.1 1.0
O D:SER190 3.9 22.9 1.0
CB A:GLU150 3.9 21.9 1.0
CG A:ASN114 3.9 20.1 1.0
C D:ALA191 4.0 19.3 1.0
CB D:ILE192 4.1 18.3 1.0
CG1 D:ILE192 4.1 18.7 1.0
CA A:LEU149 4.2 21.1 1.0
CB D:ALA191 4.2 20.0 1.0
CA D:ILE192 4.2 18.3 1.0
O A:HOH2106 4.3 48.9 1.0
CA A:GLU150 4.3 21.0 1.0
C A:LEU149 4.3 20.5 1.0
CE A:LYS79 4.4 24.0 1.0
CD1 A:LEU149 4.4 18.1 1.0
CD1 D:ILE192 4.5 19.5 1.0
O D:ILE192 4.6 20.0 1.0
C A:SER148 4.6 23.7 0.5
C A:SER148 4.6 24.2 0.5
N D:ALA191 4.7 19.9 1.0
C D:SER190 4.7 21.5 1.0
N A:LEU149 4.9 22.6 1.0
C D:ILE192 4.9 19.6 1.0
CG A:LEU149 5.0 18.6 1.0

Reference:

D.W.Banner, B.Gsell, J.Benz, J.Bertschinger, D.Burger, S.Brack, S.Cuppuleri, M.Debulpaep, A.Gast, D.Grabulovski, M.Hennig, H.Hilpert, W.Huber, A.Kuglstatter, E.Kusznir, T.Laeremans, H.Matile, C.Miscenic, A.Rufer, D.Schlatter, J.Steyeart, M.Stihle, R.Thoma, M.Weber, A.Ruf. Mapping the Conformational Space Accessible to BACE2 Using Surface Mutants and Co-Crystals with Fab-Fragments, Fynomers, and Xaperones Acta Crystallogr.,Sect.D V. 69 1124 2013.
ISSN: ISSN 0907-4449
PubMed: 23695257
DOI: 10.1107/S0907444913006574
Page generated: Sat Dec 12 10:26:25 2020

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