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Chlorine in PDB 4btu: Factor Xa in Complex with the Dual Thrombin-Fxa Inhibitor 57.

Enzymatic activity of Factor Xa in Complex with the Dual Thrombin-Fxa Inhibitor 57.

All present enzymatic activity of Factor Xa in Complex with the Dual Thrombin-Fxa Inhibitor 57.:
3.4.21.6;

Protein crystallography data

The structure of Factor Xa in Complex with the Dual Thrombin-Fxa Inhibitor 57., PDB code: 4btu was solved by J.Meneyrol, M.Follmann, G.Lassalle, V.Wehner, G.Barre, T.Rousseaux, J.M.Altenburger, F.Petit, Z.Bocskei, C.Stehlin-Gaon, H.Schreuder, N.Alet, J.-P.Herault, L.Millet, F.Dol, C.Hasbrand, P.Schaeffer, F.Sadoun, S.Klieber, C.Briot, F.Bono, J.-M.Herbert, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 46.51 / 2.37
Space group P 32
Cell size a, b, c (Å), α, β, γ (°) 55.760, 55.760, 173.140, 90.00, 90.00, 120.00
R / Rfree (%) 16.932 / 24.761

Other elements in 4btu:

The structure of Factor Xa in Complex with the Dual Thrombin-Fxa Inhibitor 57. also contains other interesting chemical elements:

Fluorine (F) 4 atoms
Calcium (Ca) 2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Factor Xa in Complex with the Dual Thrombin-Fxa Inhibitor 57. (pdb code 4btu). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 8 binding sites of Chlorine where determined in the Factor Xa in Complex with the Dual Thrombin-Fxa Inhibitor 57., PDB code: 4btu:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Chlorine binding site 1 out of 8 in 4btu

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Chlorine binding site 1 out of 8 in the Factor Xa in Complex with the Dual Thrombin-Fxa Inhibitor 57.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Factor Xa in Complex with the Dual Thrombin-Fxa Inhibitor 57. within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl1246

b:37.0
occ:0.50
 CL3 B:6XS1246 0.0 37.0 0.5
CL3 B:6XS1246 0.1 40.9 0.5
C31 B:6XS1246 1.7 36.7 0.5
C31 B:6XS1246 1.8 40.7 0.5
C32 B:6XS1246 2.7 36.6 0.5
C32 B:6XS1246 2.8 40.6 0.5
S30 B:6XS1246 3.0 36.5 0.5
S30 B:6XS1246 3.1 40.5 0.5
OH B:TYR228 3.4 32.5 1.0
CZ B:TYR228 3.4 32.5 1.0
CA B:GLY226 3.5 32.8 1.0
CE2 B:TYR228 3.8 32.8 1.0
CG1 B:VAL213 3.8 31.6 1.0
CB B:ALA190 3.8 37.7 1.0
CE1 B:TYR228 3.9 32.4 1.0
C33 B:6XS1246 3.9 36.5 0.5
O B:TRP215 3.9 31.0 1.0
C33 B:6XS1246 4.0 40.6 0.5
N B:ILE227 4.0 32.8 1.0
C B:GLY226 4.0 32.9 1.0
O B:ILE227 4.1 32.9 1.0
C29 B:6XS1246 4.2 36.7 0.5
OD1 B:ASP189 4.2 38.9 1.0
C29 B:6XS1246 4.2 40.8 0.5
CD2 B:TYR228 4.5 32.7 1.0
O B:HOH2169 4.5 32.4 1.0
C B:TRP215 4.5 31.3 1.0
CD1 B:TYR228 4.6 32.7 1.0
O B:ALA190 4.7 37.3 1.0
CA B:ALA190 4.7 37.9 1.0
C B:ILE227 4.7 33.1 1.0
C B:ALA190 4.8 37.5 1.0
N B:GLY226 4.8 32.6 1.0
N B:TRP215 4.8 30.7 1.0
CG B:TYR228 4.9 32.8 1.0
N B:ALA190 4.9 38.4 1.0
CB B:VAL213 4.9 31.3 1.0
N B:SER214 4.9 31.2 1.0
O B:GLY226 4.9 32.9 1.0
CA B:VAL213 5.0 31.2 1.0
CA B:ILE227 5.0 33.0 1.0

Chlorine binding site 2 out of 8 in 4btu

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Chlorine binding site 2 out of 8 in the Factor Xa in Complex with the Dual Thrombin-Fxa Inhibitor 57.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Factor Xa in Complex with the Dual Thrombin-Fxa Inhibitor 57. within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl1246

b:38.3
occ:0.50
 CL4 B:6XS1246 0.0 38.3 0.5
C11 B:6XS1246 0.7 44.2 0.5
C10 B:6XS1246 0.8 44.0 0.5
C12 B:6XS1246 1.7 44.3 0.5
C8 B:6XS1246 1.7 38.5 0.5
C9 B:6XS1246 1.8 43.8 0.5
F13 B:6XS1246 1.9 44.3 0.5
C7 B:6XS1246 2.3 44.2 0.5
C8 B:6XS1246 2.3 44.0 0.5
C9 B:6XS1246 2.7 38.5 0.5
C7 B:6XS1246 2.7 38.6 0.5
O36 B:6XS1246 2.7 38.6 0.5
C2 B:6XS1246 2.7 38.8 0.5
N3 B:6XS1246 3.0 38.8 0.5
S15 B:6XS1246 3.1 38.5 0.5
S15 B:6XS1246 3.3 43.6 0.5
N16 B:6XS1246 3.6 38.2 0.5
N3 B:6XS1246 3.7 44.2 0.5
O B:GLY216 3.8 33.1 1.0
O36 B:6XS1246 3.9 43.7 0.5
N16 B:6XS1246 3.9 43.1 0.5
C10 B:6XS1246 4.0 38.5 0.5
C12 B:6XS1246 4.0 38.4 0.5
CL4 B:6XS1246 4.0 44.2 0.5
O35 B:6XS1246 4.2 43.9 0.5
C1 B:6XS1246 4.2 38.8 0.5
C4 B:6XS1246 4.2 39.0 0.5
CA B:GLU217 4.3 33.2 1.0
C B:GLY216 4.3 32.8 1.0
CE2 B:PHE174 4.3 34.5 1.0
O38 B:6XS1246 4.3 37.6 0.5
O38 B:6XS1246 4.4 42.3 0.5
CE3 B:TRP215 4.4 32.7 1.0
C4 B:6XS1246 4.4 44.2 0.5
O37 B:6XS1246 4.4 43.5 0.5
N B:GLU217 4.5 32.8 1.0
C11 B:6XS1246 4.5 38.3 0.5
O37 B:6XS1246 4.5 38.7 0.5
CG B:GLU217 4.7 33.2 1.0
C17 B:6XS1246 4.7 37.8 0.5
C18 B:6XS1246 4.8 37.6 0.5
C2 B:6XS1246 4.8 44.1 0.5
C6 B:6XS1246 4.8 38.9 0.5
CD2 B:PHE174 4.8 33.9 1.0
O35 B:6XS1246 4.8 39.4 0.5
C18 B:6XS1246 4.9 42.3 0.5
CZ3 B:TRP215 4.9 32.8 1.0
CZ B:PHE174 4.9 34.4 1.0
C17 B:6XS1246 5.0 42.5 0.5

Chlorine binding site 3 out of 8 in 4btu

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Chlorine binding site 3 out of 8 in the Factor Xa in Complex with the Dual Thrombin-Fxa Inhibitor 57.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Factor Xa in Complex with the Dual Thrombin-Fxa Inhibitor 57. within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl1246

b:40.9
occ:0.50
 CL3 B:6XS1246 0.0 40.9 0.5
CL3 B:6XS1246 0.1 37.0 0.5
C31 B:6XS1246 1.7 36.7 0.5
C31 B:6XS1246 1.7 40.7 0.5
C32 B:6XS1246 2.7 36.6 0.5
C32 B:6XS1246 2.7 40.6 0.5
S30 B:6XS1246 3.0 36.5 0.5
S30 B:6XS1246 3.0 40.5 0.5
CZ B:TYR228 3.5 32.5 1.0
OH B:TYR228 3.5 32.5 1.0
CA B:GLY226 3.5 32.8 1.0
CE2 B:TYR228 3.8 32.8 1.0
CG1 B:VAL213 3.8 31.6 1.0
O B:TRP215 3.8 31.0 1.0
CB B:ALA190 3.9 37.7 1.0
C33 B:6XS1246 3.9 36.5 0.5
N B:ILE227 3.9 32.8 1.0
C33 B:6XS1246 3.9 40.6 0.5
CE1 B:TYR228 3.9 32.4 1.0
C B:GLY226 4.0 32.9 1.0
O B:ILE227 4.1 32.9 1.0
C29 B:6XS1246 4.1 36.7 0.5
C29 B:6XS1246 4.2 40.8 0.5
OD1 B:ASP189 4.2 38.9 1.0
C B:TRP215 4.5 31.3 1.0
CD2 B:TYR228 4.5 32.7 1.0
O B:HOH2169 4.5 32.4 1.0
CD1 B:TYR228 4.6 32.7 1.0
C B:ILE227 4.7 33.1 1.0
O B:ALA190 4.7 37.3 1.0
N B:TRP215 4.8 30.7 1.0
CA B:ALA190 4.8 37.9 1.0
C B:ALA190 4.8 37.5 1.0
N B:GLY226 4.8 32.6 1.0
N B:SER214 4.8 31.2 1.0
CG B:TYR228 4.9 32.8 1.0
CB B:VAL213 4.9 31.3 1.0
O B:GLY226 4.9 32.9 1.0
CA B:ILE227 4.9 33.0 1.0
N B:ALA190 5.0 38.4 1.0
CA B:VAL213 5.0 31.2 1.0

Chlorine binding site 4 out of 8 in 4btu

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Chlorine binding site 4 out of 8 in the Factor Xa in Complex with the Dual Thrombin-Fxa Inhibitor 57.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Factor Xa in Complex with the Dual Thrombin-Fxa Inhibitor 57. within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl1246

b:44.2
occ:0.50
 CL4 B:6XS1246 0.0 44.2 0.5
C10 B:6XS1246 0.9 38.5 0.5
C11 B:6XS1246 1.0 38.3 0.5
C8 B:6XS1246 1.7 44.0 0.5
C9 B:6XS1246 1.8 38.5 0.5
C12 B:6XS1246 1.9 38.4 0.5
F13 B:6XS1246 2.1 38.2 0.5
C8 B:6XS1246 2.4 38.5 0.5
C7 B:6XS1246 2.4 38.6 0.5
O37 B:6XS1246 2.5 43.5 0.5
C2 B:6XS1246 2.5 44.1 0.5
C7 B:6XS1246 2.7 44.2 0.5
C9 B:6XS1246 2.7 43.8 0.5
N3 B:6XS1246 3.0 44.2 0.5
S15 B:6XS1246 3.2 43.6 0.5
S15 B:6XS1246 3.3 38.5 0.5
C1 B:6XS1246 3.3 44.2 0.5
O37 B:6XS1246 3.6 38.7 0.5
N3 B:6XS1246 3.8 38.8 0.5
C21 B:6XS1246 3.9 37.6 0.5
O35 B:6XS1246 4.0 39.4 0.5
C12 B:6XS1246 4.0 44.3 0.5
C21 B:6XS1246 4.0 42.1 0.5
C10 B:6XS1246 4.0 44.0 0.5
CL4 B:6XS1246 4.0 38.3 0.5
O36 B:6XS1246 4.1 43.7 0.5
O36 B:6XS1246 4.2 38.6 0.5
C4 B:6XS1246 4.3 44.2 0.5
N19 B:6XS1246 4.3 37.5 0.5
C18 B:6XS1246 4.3 37.6 0.5
N19 B:6XS1246 4.4 42.1 0.5
C4 B:6XS1246 4.4 39.0 0.5
C18 B:6XS1246 4.4 42.3 0.5
C23 B:6XS1246 4.4 42.1 0.5
N16 B:6XS1246 4.4 38.2 0.5
C23 B:6XS1246 4.4 37.5 0.5
C20 B:6XS1246 4.4 37.6 0.5
N16 B:6XS1246 4.4 43.1 0.5
C17 B:6XS1246 4.5 37.8 0.5
C11 B:6XS1246 4.5 44.2 0.5
C20 B:6XS1246 4.5 42.1 0.5
C17 B:6XS1246 4.6 42.5 0.5
N22 B:6XS1246 4.6 37.6 0.5
N22 B:6XS1246 4.7 42.1 0.5
C6 B:6XS1246 4.7 44.2 0.5
O38 B:6XS1246 4.8 37.6 0.5
O38 B:6XS1246 4.8 42.3 0.5
C24 B:6XS1246 4.9 37.5 0.5
C25 B:6XS1246 4.9 37.5 0.5
C24 B:6XS1246 4.9 42.1 0.5
C25 B:6XS1246 4.9 42.0 0.5
C2 B:6XS1246 4.9 38.8 0.5
OH B:TYR99 4.9 41.4 1.0

Chlorine binding site 5 out of 8 in 4btu

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Chlorine binding site 5 out of 8 in the Factor Xa in Complex with the Dual Thrombin-Fxa Inhibitor 57.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Factor Xa in Complex with the Dual Thrombin-Fxa Inhibitor 57. within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Cl1246

b:34.2
occ:0.50
 CL3 F:6XS1246 0.0 34.2 0.5
CL3 F:6XS1246 0.1 35.8 0.5
C31 F:6XS1246 1.7 36.1 0.5
C31 F:6XS1246 1.7 34.5 0.5
C32 F:6XS1246 2.7 36.2 0.5
C32 F:6XS1246 2.7 34.5 0.5
S30 F:6XS1246 2.9 36.3 0.5
S30 F:6XS1246 3.0 34.7 0.5
O F:ILE227 3.5 33.0 1.0
CZ F:TYR228 3.6 32.2 1.0
CG1 F:VAL213 3.6 28.0 1.0
O F:TRP215 3.7 29.6 1.0
N F:ILE227 3.7 33.5 1.0
CE2 F:TYR228 3.8 32.4 1.0
CB F:ALA190 3.8 38.7 1.0
OH F:TYR228 3.9 32.0 1.0
CA F:GLY226 3.9 34.6 1.0
C33 F:6XS1246 3.9 36.5 0.5
C33 F:6XS1246 3.9 34.8 0.5
CE1 F:TYR228 4.0 32.1 1.0
C F:GLY226 4.1 34.2 1.0
C29 F:6XS1246 4.1 36.9 0.5
C29 F:6XS1246 4.2 35.2 0.5
C F:ILE227 4.2 33.1 1.0
CD2 F:TYR228 4.3 32.4 1.0
C F:TRP215 4.4 29.7 1.0
CD1 F:TYR228 4.5 32.2 1.0
N F:SER214 4.5 27.8 1.0
N F:TRP215 4.5 28.8 1.0
CB F:VAL213 4.6 27.8 1.0
CG F:TYR228 4.6 32.3 1.0
CA F:ILE227 4.6 33.4 1.0
CA F:VAL213 4.7 27.7 1.0
CA F:ALA190 4.9 38.6 1.0
O F:ALA190 4.9 38.4 1.0
OD1 F:ASP189 4.9 40.4 1.0
CA F:TRP215 4.9 29.4 1.0
CG2 F:VAL213 4.9 27.9 1.0
C F:VAL213 5.0 27.7 1.0
C F:ALA190 5.0 38.2 1.0

Chlorine binding site 6 out of 8 in 4btu

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Chlorine binding site 6 out of 8 in the Factor Xa in Complex with the Dual Thrombin-Fxa Inhibitor 57.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of Factor Xa in Complex with the Dual Thrombin-Fxa Inhibitor 57. within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Cl1246

b:40.1
occ:0.50
 CL4 F:6XS1246 0.0 40.1 0.5
C10 F:6XS1246 0.4 45.8 0.5
C11 F:6XS1246 1.1 46.2 0.5
C9 F:6XS1246 1.4 45.4 0.5
C8 F:6XS1246 1.7 40.6 0.5
C12 F:6XS1246 2.0 46.3 0.5
C8 F:6XS1246 2.2 46.1 0.5
F13 F:6XS1246 2.2 46.7 0.5
C7 F:6XS1246 2.4 46.3 0.5
C2 F:6XS1246 2.5 40.7 0.5
C9 F:6XS1246 2.7 40.5 0.5
C7 F:6XS1246 2.7 40.6 0.5
O36 F:6XS1246 2.9 40.3 0.5
S15 F:6XS1246 2.9 44.6 0.5
N3 F:6XS1246 3.0 40.8 0.5
S15 F:6XS1246 3.1 40.4 0.5
N16 F:6XS1246 3.4 39.6 0.5
O36 F:6XS1246 3.5 44.5 0.5
O F:GLY216 3.5 31.4 1.0
N16 F:6XS1246 3.6 43.3 0.5
C1 F:6XS1246 3.7 40.6 0.5
N3 F:6XS1246 3.8 46.4 0.5
O38 F:6XS1246 3.8 41.9 0.5
CL4 F:6XS1246 3.9 46.9 0.5
C10 F:6XS1246 4.0 40.7 0.5
O38 F:6XS1246 4.0 39.0 0.5
C12 F:6XS1246 4.0 40.6 0.5
O37 F:6XS1246 4.0 44.8 0.5
C F:GLY216 4.3 31.2 1.0
C18 F:6XS1246 4.3 41.8 0.5
C4 F:6XS1246 4.3 41.2 0.5
O35 F:6XS1246 4.4 46.9 0.5
C18 F:6XS1246 4.4 38.9 0.5
C17 F:6XS1246 4.5 38.7 0.5
CE3 F:TRP215 4.5 30.3 1.0
C11 F:6XS1246 4.5 40.7 0.5
C17 F:6XS1246 4.5 41.8 0.5
O37 F:6XS1246 4.6 40.6 0.5
C4 F:6XS1246 4.6 46.8 0.5
CA F:GLU217 4.7 32.3 1.0
C2 F:6XS1246 4.7 46.5 0.5
CE2 F:PHE174 4.8 45.6 1.0
N F:GLU217 4.8 31.8 1.0
N F:GLY216 5.0 29.9 1.0
C6 F:6XS1246 5.0 40.9 0.5

Chlorine binding site 7 out of 8 in 4btu

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Chlorine binding site 7 out of 8 in the Factor Xa in Complex with the Dual Thrombin-Fxa Inhibitor 57.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 7 of Factor Xa in Complex with the Dual Thrombin-Fxa Inhibitor 57. within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Cl1246

b:35.8
occ:0.50
 CL3 F:6XS1246 0.0 35.8 0.5
CL3 F:6XS1246 0.1 34.2 0.5
C31 F:6XS1246 1.7 36.1 0.5
C31 F:6XS1246 1.8 34.5 0.5
C32 F:6XS1246 2.7 36.2 0.5
C32 F:6XS1246 2.8 34.5 0.5
S30 F:6XS1246 3.0 36.3 0.5
S30 F:6XS1246 3.1 34.7 0.5
CZ F:TYR228 3.6 32.2 1.0
O F:ILE227 3.6 33.0 1.0
CG1 F:VAL213 3.7 28.0 1.0
N F:ILE227 3.7 33.5 1.0
CE2 F:TYR228 3.7 32.4 1.0
O F:TRP215 3.7 29.6 1.0
CB F:ALA190 3.8 38.7 1.0
OH F:TYR228 3.8 32.0 1.0
CA F:GLY226 3.8 34.6 1.0
C33 F:6XS1246 3.9 36.5 0.5
CE1 F:TYR228 3.9 32.1 1.0
C33 F:6XS1246 4.0 34.8 0.5
C F:GLY226 4.0 34.2 1.0
C29 F:6XS1246 4.2 36.9 0.5
C29 F:6XS1246 4.2 35.2 0.5
C F:ILE227 4.2 33.1 1.0
CD2 F:TYR228 4.2 32.4 1.0
CD1 F:TYR228 4.4 32.2 1.0
C F:TRP215 4.5 29.7 1.0
N F:SER214 4.5 27.8 1.0
CG F:TYR228 4.6 32.3 1.0
N F:TRP215 4.6 28.8 1.0
CA F:ILE227 4.6 33.4 1.0
CB F:VAL213 4.6 27.8 1.0
CA F:VAL213 4.7 27.7 1.0
OD1 F:ASP189 4.8 40.4 1.0
CA F:ALA190 4.8 38.6 1.0
O F:ALA190 4.9 38.4 1.0
CG2 F:VAL213 4.9 27.9 1.0
O F:GLY226 5.0 33.8 1.0
CA F:TRP215 5.0 29.4 1.0
C F:ALA190 5.0 38.2 1.0

Chlorine binding site 8 out of 8 in 4btu

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Chlorine binding site 8 out of 8 in the Factor Xa in Complex with the Dual Thrombin-Fxa Inhibitor 57.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 8 of Factor Xa in Complex with the Dual Thrombin-Fxa Inhibitor 57. within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Cl1246

b:46.9
occ:0.50
 CL4 F:6XS1246 0.0 46.9 0.5
C10 F:6XS1246 0.2 40.7 0.5
C11 F:6XS1246 1.3 40.7 0.5
C9 F:6XS1246 1.3 40.5 0.5
C8 F:6XS1246 1.7 46.1 0.5
C12 F:6XS1246 2.2 40.6 0.5
C8 F:6XS1246 2.2 40.6 0.5
F13 F:6XS1246 2.4 40.8 0.5
O37 F:6XS1246 2.4 44.8 0.5
C7 F:6XS1246 2.6 40.6 0.5
C2 F:6XS1246 2.6 46.5 0.5
C7 F:6XS1246 2.7 46.3 0.5
C9 F:6XS1246 2.7 45.4 0.5
S15 F:6XS1246 2.8 40.4 0.5
N3 F:6XS1246 3.0 46.4 0.5
O37 F:6XS1246 3.1 40.6 0.5
S15 F:6XS1246 3.1 44.6 0.5
C1 F:6XS1246 3.6 46.6 0.5
O36 F:6XS1246 3.8 40.3 0.5
N16 F:6XS1246 3.8 39.6 0.5
C21 F:6XS1246 3.8 41.8 0.5
C17 F:6XS1246 3.8 38.7 0.5
CL4 F:6XS1246 3.9 40.1 0.5
C21 F:6XS1246 3.9 39.0 0.5
N3 F:6XS1246 3.9 40.8 0.5
C18 F:6XS1246 4.0 41.8 0.5
C17 F:6XS1246 4.0 41.8 0.5
C18 F:6XS1246 4.0 38.9 0.5
C12 F:6XS1246 4.0 46.3 0.5
C10 F:6XS1246 4.0 45.8 0.5
N19 F:6XS1246 4.0 41.8 0.5
C20 F:6XS1246 4.1 38.9 0.5
C20 F:6XS1246 4.1 41.8 0.5
N19 F:6XS1246 4.1 38.9 0.5
N16 F:6XS1246 4.2 43.3 0.5
C4 F:6XS1246 4.2 46.8 0.5
O36 F:6XS1246 4.3 44.5 0.5
C11 F:6XS1246 4.5 46.2 0.5
O38 F:6XS1246 4.5 41.9 0.5
C23 F:6XS1246 4.5 41.8 0.5
O38 F:6XS1246 4.6 39.0 0.5
O35 F:6XS1246 4.6 41.6 0.5
N22 F:6XS1246 4.7 41.9 0.5
C24 F:6XS1246 4.8 41.7 0.5
C23 F:6XS1246 4.8 38.9 0.5
C4 F:6XS1246 4.8 41.2 0.5
C2 F:6XS1246 4.9 40.7 0.5
N22 F:6XS1246 4.9 39.1 0.5
O F:HOH2156 4.9 31.3 1.0
C6 F:6XS1246 4.9 46.9 0.5
O35 F:6XS1246 4.9 46.9 0.5
C24 F:6XS1246 4.9 38.9 0.5

Reference:

J.Meneyrol, M.Follmann, G.Lassalle, V.Wehner, G.Barre, T.Rousseaux, J.Altenburger, F.Petit, Z.Bocskei, H.Schreuder, N.Alet, J.Herault, L.Millet, F.Dol, P.Florian, P.Schaeffer, F.Sadoun, S.Klieber, C.Briot, F.Bono, J.Herbert. 5-Chlorothiophene-2-Carboxylic Acid [(S)-2-[2-Methyl-3-(2- Oxopyrrolidin-1-Yl)Benzenesulfonylamino]-3-(4- Methylpiperazin-1-Yl)-3-Oxopropyl]Amide (SAR107375), A Selective and Potent Orally Active Dual Thrombin and Factor Xa Inhibitor. J.Med.Chem. V. 56 9441 2013.
ISSN: ISSN 0022-2623
PubMed: 24175584
DOI: 10.1021/JM4005835
Page generated: Sat Dec 12 10:27:32 2020

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