Chlorine in PDB 4bx8: Human VPS33A

The structure of Human VPS33A, PDB code: 4bx8 was solved by S.C.Graham, L.Wartosch, S.R.Gray, E.J.Scourfield, J.E.Deane, J.P.Luzio, D.J.Owen, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	64.61 / 2.40
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	71.470, 125.010, 83.280, 90.00, 115.33, 90.00
R / Rfree (%)	19.7 / 24.4

The binding sites of Chlorine atom in the Human VPS33A (pdb code 4bx8). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Human VPS33A, PDB code: 4bx8:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Human VPS33A


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Human VPS33A within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1001 b:79.2 occ:1.00 NZ A:LYS373 3.4 45.0 1.0 O A:HOH2015 3.8 52.6 1.0 CG1 A:ILE253 4.1 41.9 1.0 CG1 A:VAL364 4.2 46.6 1.0 CE1 A:PHE370 4.2 44.6 1.0 CD1 A:PHE370 4.4 45.7 1.0 CB A:GLU252 4.5 37.5 1.0 CE A:LYS373 4.6 41.0 1.0 CG2 A:THR242 4.7 37.7 1.0 O A:GLU252 4.9 36.7 1.0 CD1 A:ILE253 4.9 42.8 1.0 C A:GLU252 5.0 35.7 1.0 O A:HOH2026 5.0 45.6 1.0

Chlorine binding site 2 out of 2 in the Human VPS33A


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Human VPS33A within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl1001 b:75.0 occ:1.00 NZ B:LYS373 3.1 40.8 1.0 CE1 B:PHE370 4.0 40.3 1.0 CD1 B:PHE370 4.2 41.4 1.0 CE B:LYS373 4.3 40.2 1.0 CG1 B:VAL364 4.4 46.8 1.0 CG1 B:ILE253 4.4 35.6 1.0 CG2 B:THR242 4.4 36.6 1.0 CB B:GLU252 4.6 32.4 1.0

S.C.Graham, L.Wartosch, S.R.Gray, E.J.Scourfield, J.E.Deane, J.P.Luzio, D.J.Owen. Structural Basis of VPS33A Recruitment to the Human Hops Complex By VPS16. Proc.Natl.Acad.Sci.Usa V. 110 13345 2013.
ISSN: ISSN 0027-8424
PubMed: 23901104
DOI: 10.1073/PNAS.1307074110