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Atomistry » Chlorine » PDB 4c00-4c81 » 4c4g » |
Chlorine in PDB 4c4g: Structure-Based Design of Orally Bioavailable Pyrrolopyridine Inhibitors of the Mitotic Kinase MPS1Enzymatic activity of Structure-Based Design of Orally Bioavailable Pyrrolopyridine Inhibitors of the Mitotic Kinase MPS1
All present enzymatic activity of Structure-Based Design of Orally Bioavailable Pyrrolopyridine Inhibitors of the Mitotic Kinase MPS1:
2.7.12.1; Protein crystallography data
The structure of Structure-Based Design of Orally Bioavailable Pyrrolopyridine Inhibitors of the Mitotic Kinase MPS1, PDB code: 4c4g
was solved by
S.Naud,
I.M.Westwood,
A.Faisal,
P.Sheldrake,
V.Bavetsias,
B.Atrash,
M.Liu,
A.Hayes,
J.Schmitt,
A.Wood,
V.Choi,
K.Boxall,
G.Mak,
M.Gurden,
M.Valenti,
A.De Haven Brandon,
A.Henley,
R.Baker,
C.Mcandrew,
B.Matijssen,
R.Burke,
S.A.Eccles,
F.I.Raynaud,
S.Linardopoulos,
R.Van Montfort,
J.Blagg,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Structure-Based Design of Orally Bioavailable Pyrrolopyridine Inhibitors of the Mitotic Kinase MPS1
(pdb code 4c4g). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Structure-Based Design of Orally Bioavailable Pyrrolopyridine Inhibitors of the Mitotic Kinase MPS1, PDB code: 4c4g: Chlorine binding site 1 out of 1 in 4c4gGo back to Chlorine Binding Sites List in 4c4g
Chlorine binding site 1 out
of 1 in the Structure-Based Design of Orally Bioavailable Pyrrolopyridine Inhibitors of the Mitotic Kinase MPS1
Mono view Stereo pair view
Reference:
S.Naud,
I.M.Westwood,
A.Faisal,
P.W.Sheldrake,
V.Bavetsias,
B.Atrash,
K.J.Cheung,
M.Liu,
A.Hayes,
J.Schmitt,
A.Wood,
V.Choi,
K.Boxall,
G.Mak,
M.Gurden,
M.Valenti,
A.De-Haven-Brandon,
A.Henley,
R.Baker,
C.Mcandrew,
B.Matijssen,
R.Burke,
S.Hoelder,
S.A.Eccles,
F.I.Raynaud,
S.Linardopoulos,
R.L.M.Van Montfort,
J.Blagg.
Structure-Based Design of Orally Bioavailable 1H-Pyrrolo[3, 2-C]Pyridine Inhibitors of the Mitotic Kinase Monopolar Spindle 1 (MPS1). J.Med.Chem. V. 56 10045 2013.
Page generated: Sat Dec 12 10:28:23 2020
ISSN: ISSN 0022-2623 PubMed: 24256217 DOI: 10.1021/JM401395S |
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