Chlorine in PDB 4cca: Structure of Human MUNC18-2

The structure of Structure of Human MUNC18-2, PDB code: 4cca was solved by Y.Hackmann, S.C.Graham, S.Ehl, S.Hoening, K.Lehmberg, M.Arico, D.J.Owen, G.G.Griffiths, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	47.765 / 2.60
Space group	P 41 21 2
Cell size a, b, c (Å), α, β, γ (°)	67.550, 67.550, 284.651, 90.00, 90.00, 90.00
R / Rfree (%)	24.25 / 27.48

The binding sites of Chlorine atom in the Structure of Human MUNC18-2 (pdb code 4cca). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Structure of Human MUNC18-2, PDB code: 4cca:

Chlorine binding site 1 out of 1 in the Structure of Human MUNC18-2


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of Human MUNC18-2 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1594 b:64.1 occ:0.50 HH11 A:ARG493 2.4 76.7 1.0 H A:PHE498 2.7 68.9 1.0 HD3 A:ARG493 3.0 78.1 1.0 HB2 A:PHE498 3.1 70.9 1.0 NH1 A:ARG493 3.2 63.9 1.0 HH12 A:ARG493 3.5 76.7 1.0 N A:PHE498 3.5 57.4 1.0 HD1 A:PHE498 3.7 70.3 1.0 HA A:PRO497 3.8 63.4 1.0 HD2 A:ARG493 3.8 78.1 1.0 CD A:ARG493 3.8 65.1 1.0 CB A:PHE498 4.0 59.1 1.0 O A:PHE498 4.0 60.6 1.0 HB2 A:PRO497 4.2 60.9 1.0 CA A:PHE498 4.2 59.0 1.0 CZ A:ARG493 4.3 64.8 1.0 HB3 A:PRO497 4.3 60.9 1.0 HB3 A:ARG493 4.3 77.1 1.0 CA A:PRO497 4.4 52.8 1.0 CD1 A:PHE498 4.4 58.6 1.0 C A:PRO497 4.4 55.3 1.0 CB A:PRO497 4.5 50.8 1.0 NE A:ARG493 4.5 65.5 1.0 C A:PHE498 4.5 60.7 1.0 CG A:PHE498 4.6 58.9 1.0 HB3 A:PHE498 4.7 70.9 1.0 CG A:ARG493 5.0 65.7 1.0

Y.Hackmann, S.C.Graham, S.Ehl, S.Hoening, K.Lehmberg, M.Arico, D.J.Owen, G.G.Griffiths. Syntaxin Binding Mechanism and Disease-Causing Mutations in MUNC18-2 Proc.Natl.Acad.Sci.Usa V. 110 E4482 2013.
ISSN: ISSN 0027-8424
PubMed: 24194549
DOI: 10.1073/PNAS.1313474110