Chlorine in PDB 4cn2: Crystal Structure of the Human Retinoid X Receptor Dna- Binding Domain Bound to the Human RAMP2 Response Element

The structure of Crystal Structure of the Human Retinoid X Receptor Dna- Binding Domain Bound to the Human RAMP2 Response Element, PDB code: 4cn2 was solved by A.G.Mcewen, P.Poussin-Courmontagne, J.Osz, N.Rochel, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	23.898 / 2.07
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	113.234, 43.952, 63.316, 90.00, 106.02, 90.00
R / Rfree (%)	16.48 / 21.42

The structure of Crystal Structure of the Human Retinoid X Receptor Dna- Binding Domain Bound to the Human RAMP2 Response Element also contains other interesting chemical elements:

Magnesium	(Mg)	7 atoms
Zinc	(Zn)	4 atoms

The binding sites of Chlorine atom in the Crystal Structure of the Human Retinoid X Receptor Dna- Binding Domain Bound to the Human RAMP2 Response Element (pdb code 4cn2). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Crystal Structure of the Human Retinoid X Receptor Dna- Binding Domain Bound to the Human RAMP2 Response Element, PDB code: 4cn2:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in the Crystal Structure of the Human Retinoid X Receptor Dna- Binding Domain Bound to the Human RAMP2 Response Element


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of the Human Retinoid X Receptor Dna- Binding Domain Bound to the Human RAMP2 Response Element within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl1214 b:44.0 occ:1.00 N C:TYR150 3.2 13.8 1.0 O C:HOH2050 3.3 33.8 1.0 CG1 C:VAL149 3.6 25.1 1.0 CD2 C:TYR150 3.6 25.6 1.0 CA C:VAL149 3.7 19.3 1.0 C C:VAL149 3.9 15.9 1.0 CB C:TYR150 4.1 25.6 1.0 CA C:TYR150 4.2 16.4 1.0 CB C:VAL149 4.2 30.9 1.0 CG C:TYR150 4.3 25.0 1.0 CB C:ALA136 4.4 17.7 1.0 CE2 C:TYR150 4.5 31.2 1.0 O C:GLY148 4.6 30.0 1.0 O C:TYR150 4.7 14.6 1.0 CG2 C:VAL149 4.7 33.6 1.0 N C:VAL149 4.9 18.8 1.0 C C:TYR150 4.9 17.0 1.0 O C:HOH2010 4.9 30.2 1.0 O C:MET198 5.0 19.7 1.0

Chlorine binding site 2 out of 4 in the Crystal Structure of the Human Retinoid X Receptor Dna- Binding Domain Bound to the Human RAMP2 Response Element


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of the Human Retinoid X Receptor Dna- Binding Domain Bound to the Human RAMP2 Response Element within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl1215 b:59.7 occ:1.00 N D:GLN188 3.1 36.0 1.0 NH1 D:ARG172 3.1 56.0 1.0 O D:HOH2012 3.2 28.6 1.0 CG D:GLN188 3.4 33.9 1.0 O D:HOH2015 3.5 43.9 1.0 CA D:CYS187 3.6 32.7 1.0 O D:ARG186 3.7 49.1 1.0 C D:CYS187 3.8 38.1 1.0 CB D:GLN188 3.8 29.6 1.0 NH2 D:ARG172 3.9 54.4 1.0 CZ D:ARG172 4.0 56.5 1.0 OE1 D:GLN188 4.0 49.9 1.0 CA D:GLN188 4.1 30.1 1.0 N D:CYS187 4.1 44.7 1.0 C D:ARG186 4.1 50.5 1.0 CD D:GLN188 4.1 39.6 1.0 O D:ASN185 4.6 46.9 1.0 CB D:CYS187 4.7 35.5 1.0 N D:TYR189 4.9 32.4 1.0 SG D:CYS187 5.0 39.0 1.0

Chlorine binding site 3 out of 4 in the Crystal Structure of the Human Retinoid X Receptor Dna- Binding Domain Bound to the Human RAMP2 Response Element


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of the Human Retinoid X Receptor Dna- Binding Domain Bound to the Human RAMP2 Response Element within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl1216 b:43.0 occ:1.00 O B:HOH2020 2.8 41.0 1.0 O B:HOH2019 3.0 18.8 1.0 NH2 D:ARG209 3.1 20.7 1.0 NE2 D:GLN206 3.2 24.6 1.0 O A:HOH2027 3.4 27.6 1.0 C2' A:DG10 3.7 19.3 1.0 C1' A:DG10 3.8 24.8 1.0 O3' B:DT10 3.8 15.0 1.0 OE1 D:GLN206 3.8 25.6 1.0 CD D:GLN206 3.9 29.9 1.0 C4' B:DT10 4.0 20.3 1.0 O4' B:DT10 4.1 23.8 1.0 C1' B:DT10 4.1 14.7 1.0 O4' A:DG10 4.3 22.4 1.0 C5' B:DG11 4.4 21.2 1.0 CZ D:ARG209 4.4 16.7 1.0 O A:HOH2021 4.4 36.3 1.0 C3' B:DT10 4.5 17.0 1.0 O2 B:DT10 4.5 20.9 1.0 O B:HOH2006 4.6 50.0 1.0 O A:HOH2022 4.8 38.6 1.0 P B:DG11 4.9 17.5 1.0 OP1 B:DG11 4.9 19.3 1.0 C2' B:DT10 4.9 14.2 1.0 C4' A:DG10 4.9 21.0 1.0 NH1 D:ARG209 4.9 25.1 1.0 C3' A:DG10 5.0 20.8 1.0 N9 A:DG10 5.0 32.3 1.0

Chlorine binding site 4 out of 4 in the Crystal Structure of the Human Retinoid X Receptor Dna- Binding Domain Bound to the Human RAMP2 Response Element


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Crystal Structure of the Human Retinoid X Receptor Dna- Binding Domain Bound to the Human RAMP2 Response Element within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl1217 b:65.1 occ:1.00 N D:THR170 3.0 45.2 1.0 CA D:TYR169 3.6 34.5 1.0 O D:THR170 3.6 38.6 1.0 C D:TYR169 3.8 44.6 1.0 O D:HOH2012 3.8 28.6 1.0 CB D:TYR169 3.9 30.5 1.0 CA D:THR170 4.0 47.4 1.0 CD1 D:TYR169 4.2 33.6 1.0 C D:THR170 4.3 42.6 1.0 CB D:THR170 4.3 53.9 1.0 CG D:TYR169 4.6 33.1 1.0 O D:THR168 4.6 42.4 1.0 OE1 D:GLN188 4.6 49.9 1.0 OG1 D:THR170 4.7 56.3 1.0 N D:TYR169 4.8 42.4 1.0 O D:TYR169 5.0 41.2 1.0

J.Osz, A.G.Mcewen, P.Poussin-Courmontagne, E.Moutier, C.Birck, I.Davidson, D.Moras, N.Rochel. Structural Basis of Natural Promoter Recognition By the Retinoid X Nuclear Receptor. Sci.Rep. V. 5 8216 2015.
ISSN: ISSN 2045-2322
PubMed: 25645674
DOI: 10.1038/SREP08216