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Chlorine in PDB 4cof: Crystal Structure of A Human Gamma-Aminobutyric Acid Receptor, the Gaba(A)R-BETA3 Homopentamer

Protein crystallography data

The structure of Crystal Structure of A Human Gamma-Aminobutyric Acid Receptor, the Gaba(A)R-BETA3 Homopentamer, PDB code: 4cof was solved by P.S.Miller, A.R.Aricescu, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 40.00 / 2.97
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 174.100, 108.900, 207.440, 90.00, 107.43, 90.00
R / Rfree (%) 20.53 / 22.59

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of A Human Gamma-Aminobutyric Acid Receptor, the Gaba(A)R-BETA3 Homopentamer (pdb code 4cof). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 5 binding sites of Chlorine where determined in the Crystal Structure of A Human Gamma-Aminobutyric Acid Receptor, the Gaba(A)R-BETA3 Homopentamer, PDB code: 4cof:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5;

Chlorine binding site 1 out of 5 in 4cof

Go back to Chlorine Binding Sites List in 4cof
Chlorine binding site 1 out of 5 in the Crystal Structure of A Human Gamma-Aminobutyric Acid Receptor, the Gaba(A)R-BETA3 Homopentamer


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of A Human Gamma-Aminobutyric Acid Receptor, the Gaba(A)R-BETA3 Homopentamer within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1448

b:97.8
occ:1.00
 N B:SER104 3.3 71.6 1.0
O B:SER104 3.6 72.0 1.0
N A:GLY108 3.7 71.9 1.0
ND1 A:HIS107 3.8 79.7 1.0
CA A:HIS107 3.8 74.4 1.0
CE1 A:PHE105 3.8 80.9 1.0
CB A:HIS107 3.9 75.2 1.0
CA B:LYS103 4.0 72.7 1.0
C B:LYS103 4.1 78.2 1.0
CG A:HIS107 4.1 78.2 1.0
CA B:SER104 4.1 70.2 1.0
C B:SER104 4.3 72.0 1.0
C A:HIS107 4.3 78.5 1.0
CB B:SER104 4.3 76.2 1.0
OD2 B:ASP101 4.3 0.9 1.0
CD1 A:PHE105 4.5 80.3 1.0
CZ A:PHE105 4.7 78.4 1.0
CE1 A:HIS107 4.7 78.7 1.0
CB B:LYS103 4.8 74.1 1.0
N A:VAL109 4.8 73.9 1.0
CA A:GLY108 4.8 72.1 1.0
N B:LYS103 4.9 73.0 1.0
CG2 A:VAL109 5.0 78.5 1.0
O B:LYS102 5.0 76.3 1.0

Chlorine binding site 2 out of 5 in 4cof

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Chlorine binding site 2 out of 5 in the Crystal Structure of A Human Gamma-Aminobutyric Acid Receptor, the Gaba(A)R-BETA3 Homopentamer


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of A Human Gamma-Aminobutyric Acid Receptor, the Gaba(A)R-BETA3 Homopentamer within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl1448

b:0.1
occ:1.00
 N C:SER104 3.2 71.8 1.0
ND1 B:HIS107 3.6 71.9 1.0
O C:SER104 3.7 74.1 1.0
N B:GLY108 3.7 74.2 1.0
CA B:HIS107 3.8 68.0 1.0
CB B:HIS107 3.8 68.0 1.0
OD2 C:ASP101 3.8 0.1 1.0
CA C:LYS103 4.0 69.8 1.0
CG B:HIS107 4.0 69.8 1.0
C C:LYS103 4.0 76.5 1.0
CE1 B:PHE105 4.0 73.4 1.0
CA C:SER104 4.1 71.5 1.0
CB C:SER104 4.1 77.6 1.0
C B:HIS107 4.3 74.5 1.0
C C:SER104 4.3 75.0 1.0
CE1 B:HIS107 4.6 70.1 1.0
N B:VAL109 4.6 71.0 1.0
CG C:ASP101 4.7 0.2 1.0
OD1 C:ASP101 4.7 1.0 1.0
CD1 B:PHE105 4.8 72.6 1.0
CA B:GLY108 4.8 74.8 1.0
CZ B:PHE105 4.9 70.5 1.0
N C:LYS103 4.9 69.8 1.0
CB C:LYS103 4.9 71.4 1.0
CG2 B:VAL109 4.9 75.2 1.0
O C:LYS102 4.9 77.4 1.0
CG C:LYS103 5.0 94.0 1.0

Chlorine binding site 3 out of 5 in 4cof

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Chlorine binding site 3 out of 5 in the Crystal Structure of A Human Gamma-Aminobutyric Acid Receptor, the Gaba(A)R-BETA3 Homopentamer


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of A Human Gamma-Aminobutyric Acid Receptor, the Gaba(A)R-BETA3 Homopentamer within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl1448

b:0.7
occ:1.00
 N D:SER104 3.5 73.1 1.0
N C:GLY108 3.5 74.9 1.0
CA C:HIS107 3.6 71.7 1.0
O D:SER104 3.7 80.0 1.0
ND1 C:HIS107 3.8 77.8 1.0
CB C:HIS107 3.8 72.9 1.0
CE1 C:PHE105 3.9 82.4 1.0
CG C:HIS107 4.1 75.4 1.0
C C:HIS107 4.1 77.8 1.0
CA D:LYS103 4.2 73.6 1.0
OD2 D:ASP101 4.2 0.7 1.0
C D:LYS103 4.3 79.2 1.0
CA D:SER104 4.3 72.9 1.0
CB D:SER104 4.4 77.6 1.0
C D:SER104 4.4 78.9 1.0
CD1 C:PHE105 4.5 81.6 1.0
CA C:GLY108 4.6 76.6 1.0
N C:VAL109 4.6 77.2 1.0
CE1 C:HIS107 4.8 75.8 1.0
CZ C:PHE105 4.8 79.5 1.0
N C:HIS107 4.9 70.8 1.0
NZ D:LYS103 4.9 0.1 1.0
O C:VAL106 4.9 75.3 1.0
CB D:LYS103 5.0 75.2 1.0

Chlorine binding site 4 out of 5 in 4cof

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Chlorine binding site 4 out of 5 in the Crystal Structure of A Human Gamma-Aminobutyric Acid Receptor, the Gaba(A)R-BETA3 Homopentamer


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Crystal Structure of A Human Gamma-Aminobutyric Acid Receptor, the Gaba(A)R-BETA3 Homopentamer within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cl1449

b:0.5
occ:1.00
 N D:GLY108 3.4 81.9 1.0
N E:SER104 3.4 79.5 1.0
CA D:HIS107 3.6 81.9 1.0
O E:SER104 3.7 84.2 1.0
CB D:HIS107 3.8 82.9 1.0
ND1 D:HIS107 3.8 87.4 1.0
C D:HIS107 4.0 85.8 1.0
CE1 D:PHE105 4.1 82.9 1.0
CG D:HIS107 4.1 85.4 1.0
CA E:SER104 4.2 78.8 1.0
OD2 E:ASP101 4.2 0.9 1.0
CA E:LYS103 4.2 77.7 1.0
CB E:SER104 4.3 82.9 1.0
C E:LYS103 4.3 83.8 1.0
C E:SER104 4.3 83.2 1.0
N D:VAL109 4.5 83.5 1.0
CA D:GLY108 4.5 82.4 1.0
CD1 D:PHE105 4.7 81.7 1.0
CE1 D:HIS107 4.8 86.0 1.0
CG2 D:VAL109 4.8 88.2 1.0
N D:HIS107 4.9 81.5 1.0
C D:GLY108 4.9 88.2 1.0
CZ D:PHE105 4.9 82.1 1.0
CG E:ASP101 5.0 0.1 1.0
O D:VAL106 5.0 84.4 1.0

Chlorine binding site 5 out of 5 in 4cof

Go back to Chlorine Binding Sites List in 4cof
Chlorine binding site 5 out of 5 in the Crystal Structure of A Human Gamma-Aminobutyric Acid Receptor, the Gaba(A)R-BETA3 Homopentamer


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Crystal Structure of A Human Gamma-Aminobutyric Acid Receptor, the Gaba(A)R-BETA3 Homopentamer within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Cl1448

b:0.5
occ:1.00
 N A:SER104 3.4 75.3 1.0
N E:GLY108 3.6 84.2 1.0
CA E:HIS107 3.6 85.4 1.0
ND1 E:HIS107 3.6 89.6 1.0
CB E:HIS107 3.7 85.7 1.0
O A:SER104 3.8 79.7 1.0
CE1 E:PHE105 3.9 82.1 1.0
CG E:HIS107 3.9 87.9 1.0
OD2 A:ASP101 4.1 0.1 1.0
CA A:LYS103 4.1 75.8 1.0
C E:HIS107 4.1 88.8 1.0
C A:LYS103 4.2 80.5 1.0
CA A:SER104 4.3 75.1 1.0
CB A:SER104 4.4 80.3 1.0
C A:SER104 4.4 79.8 1.0
CD1 E:PHE105 4.5 81.1 1.0
CE1 E:HIS107 4.6 88.3 1.0
N E:VAL109 4.7 83.3 1.0
CA E:GLY108 4.7 84.5 1.0
CZ E:PHE105 4.8 79.7 1.0
N E:HIS107 4.9 84.5 1.0
CG A:ASP101 4.9 0.3 1.0
NZ A:LYS103 4.9 1.0 1.0
OD1 A:ASP101 5.0 0.2 1.0
CD2 E:HIS107 5.0 88.5 1.0
N A:LYS103 5.0 76.8 1.0
CB A:LYS103 5.0 77.4 1.0
O E:VAL106 5.0 84.9 1.0

Reference:

P.S.Miller, A.R.Aricescu. Crystal Structure of A Human Gabaa Receptor Nature V. 512 270 2014.
ISSN: ISSN 0028-0836
PubMed: 24909990
DOI: 10.1038/NATURE13293
Page generated: Sun Jul 21 11:23:59 2024

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