Chlorine in PDB 4d4s: Focal Adhesion Kinase Catalytic Domain

All present enzymatic activity of Focal Adhesion Kinase Catalytic Domain:
2.7.10.2;

The structure of Focal Adhesion Kinase Catalytic Domain, PDB code: 4d4s was solved by J.Le Coq, A.Lin, D.Lietha, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	62.44 / 2.00
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	45.266, 124.877, 50.814, 90.00, 94.33, 90.00
R / Rfree (%)	20.632 / 22.51

The binding sites of Chlorine atom in the Focal Adhesion Kinase Catalytic Domain (pdb code 4d4s). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Focal Adhesion Kinase Catalytic Domain, PDB code: 4d4s:

Chlorine binding site 1 out of 1 in the Focal Adhesion Kinase Catalytic Domain


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Focal Adhesion Kinase Catalytic Domain within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl1690 b:54.5 occ:1.00 CL5 B:BI91690 0.0 54.5 1.0 C5 B:BI91690 1.6 53.1 1.0 CE B:MET499 2.4 37.4 1.0 C4 B:BI91690 2.6 53.3 1.0 C6 B:BI91690 2.6 51.9 1.0 NAE B:BI91690 2.8 54.3 1.0 CD1 B:LEU553 3.4 34.5 1.0 OAI B:BI91690 3.6 54.9 1.0 N3 B:BI91690 3.8 53.2 1.0 N1 B:BI91690 3.9 52.0 1.0 CE B:LYS454 4.0 38.2 1.0 CB B:ALA452 4.1 39.7 1.0 CAJ B:BI91690 4.1 54.7 1.0 SD B:MET499 4.1 37.0 1.0 C2 B:BI91690 4.4 53.4 1.0 O B:GLY563 4.5 42.2 1.0 NZ B:LYS454 4.5 38.0 1.0 CAO B:BI91690 4.5 55.3 1.0 O B:GLU500 4.5 37.4 1.0 CG1 B:VAL484 4.6 32.5 1.0 CB B:MET499 4.8 36.9 1.0 CAP B:BI91690 4.8 55.2 1.0 CG B:LEU553 4.8 32.9 1.0 CG2 B:VAL484 4.9 32.2 1.0

J.Zhou, A.Bronowska, J.Le Coq, D.Lietha, F.Grater. Allosteric Regulation of Focal Adhesion Kinase By PIP2 and Atp. Biophys.J. V. 108 698 2015.
ISSN: ISSN 0006-3495
PubMed: 25650936
DOI: 10.1016/J.BPJ.2014.11.3454