Atomistry » Chlorine » PDB 4dhn-4dph » 4dii
Atomistry »
  Chlorine »
    PDB 4dhn-4dph »
      4dii »

Chlorine in PDB 4dii: X-Ray Structure of the Complex Between Human Alpha Thrombin and Thrombin Binding Aptamer in the Presence of Potassium Ions

Enzymatic activity of X-Ray Structure of the Complex Between Human Alpha Thrombin and Thrombin Binding Aptamer in the Presence of Potassium Ions

All present enzymatic activity of X-Ray Structure of the Complex Between Human Alpha Thrombin and Thrombin Binding Aptamer in the Presence of Potassium Ions:
3.4.21.5;

Protein crystallography data

The structure of X-Ray Structure of the Complex Between Human Alpha Thrombin and Thrombin Binding Aptamer in the Presence of Potassium Ions, PDB code: 4dii was solved by I.Russo Krauss, A.Merlino, L.Mazzarella, F.Sica, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.00 / 2.05
Space group P 1
Cell size a, b, c (Å), α, β, γ (°) 43.369, 45.299, 51.519, 68.97, 86.11, 69.66
R / Rfree (%) 17.4 / 22.6

Other elements in 4dii:

The structure of X-Ray Structure of the Complex Between Human Alpha Thrombin and Thrombin Binding Aptamer in the Presence of Potassium Ions also contains other interesting chemical elements:

Potassium (K) 1 atom
Zinc (Zn) 2 atoms
Sodium (Na) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the X-Ray Structure of the Complex Between Human Alpha Thrombin and Thrombin Binding Aptamer in the Presence of Potassium Ions (pdb code 4dii). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the X-Ray Structure of the Complex Between Human Alpha Thrombin and Thrombin Binding Aptamer in the Presence of Potassium Ions, PDB code: 4dii:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in 4dii

Go back to Chlorine Binding Sites List in 4dii
Chlorine binding site 1 out of 2 in the X-Ray Structure of the Complex Between Human Alpha Thrombin and Thrombin Binding Aptamer in the Presence of Potassium Ions


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of X-Ray Structure of the Complex Between Human Alpha Thrombin and Thrombin Binding Aptamer in the Presence of Potassium Ions within 5.0Å range:
probe atom residue distance (Å) B Occ
H:Cl305

b:22.5
occ:1.00
O H:HOH462 3.0 20.1 1.0
ZN H:ZN304 3.2 40.2 1.0
O H:HOH516 4.0 38.1 1.0
CL H:CL306 4.2 40.6 1.0
OD1 H:ASP60E 4.7 34.2 1.0

Chlorine binding site 2 out of 2 in 4dii

Go back to Chlorine Binding Sites List in 4dii
Chlorine binding site 2 out of 2 in the X-Ray Structure of the Complex Between Human Alpha Thrombin and Thrombin Binding Aptamer in the Presence of Potassium Ions


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of X-Ray Structure of the Complex Between Human Alpha Thrombin and Thrombin Binding Aptamer in the Presence of Potassium Ions within 5.0Å range:
probe atom residue distance (Å) B Occ
H:Cl306

b:40.6
occ:1.00
O H:HOH462 2.5 20.1 1.0
ZN H:ZN304 2.8 40.2 1.0
OD2 H:ASP60E 3.7 36.6 1.0
OD1 H:ASP60E 3.9 34.2 1.0
O H:HOH516 3.9 38.1 1.0
O H:ASP60E 4.0 32.6 1.0
CG H:ASP60E 4.1 36.0 1.0
CL H:CL305 4.2 22.5 1.0
O H:HOH539 4.9 50.6 1.0

Reference:

I.Russo Krauss, A.Merlino, A.Randazzo, E.Novellino, L.Mazzarella, F.Sica. High-Resolution Structures of Two Complexes Between Thrombin and Thrombin-Binding Aptamer Shed Light on the Role of Cations in the Aptamer Inhibitory Activity. Nucleic Acids Res. V. 40 8119 2012.
ISSN: ISSN 0305-1048
PubMed: 22669903
DOI: 10.1093/NAR/GKS512
Page generated: Sat Dec 12 10:32:14 2020

Last articles

Zn in 8WB0
Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy