Chlorine in PDB 4dt8: Crystal Structure of Aminoglycoside-2''-Phosphotransferase Type Iva in Complex with Adenosine

The structure of Crystal Structure of Aminoglycoside-2''-Phosphotransferase Type Iva in Complex with Adenosine, PDB code: 4dt8 was solved by K.Shi, A.M.Berghuis, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	41.94 / 2.15
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	42.664, 101.403, 73.588, 90.00, 100.56, 90.00
R / Rfree (%)	19 / 24.5

The binding sites of Chlorine atom in the Crystal Structure of Aminoglycoside-2''-Phosphotransferase Type Iva in Complex with Adenosine (pdb code 4dt8). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Aminoglycoside-2''-Phosphotransferase Type Iva in Complex with Adenosine, PDB code: 4dt8:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Crystal Structure of Aminoglycoside-2''-Phosphotransferase Type Iva in Complex with Adenosine


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Aminoglycoside-2''-Phosphotransferase Type Iva in Complex with Adenosine within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl402 b:33.1 occ:1.00 N A:ASN134 3.3 26.8 1.0 CE A:LYS70 3.6 30.1 1.0 CG2 A:ILE133 3.8 23.3 1.0 CB A:ASN134 3.9 32.1 1.0 CA A:ILE133 4.0 22.4 1.0 CD A:LYS70 4.0 28.3 1.0 C A:ILE133 4.2 24.2 1.0 CA A:ASN134 4.2 30.0 1.0 CB A:ILE133 4.3 22.5 1.0 CG1 A:ILE133 4.5 24.2 1.0 O A:ASN134 4.7 27.6 1.0 C A:ASN134 5.0 29.4 1.0

Chlorine binding site 2 out of 2 in the Crystal Structure of Aminoglycoside-2''-Phosphotransferase Type Iva in Complex with Adenosine


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Aminoglycoside-2''-Phosphotransferase Type Iva in Complex with Adenosine within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl402 b:38.4 occ:1.00 O B:HOH512 3.3 31.5 1.0 CE1 B:HIS251 3.3 23.2 1.0 NZ B:LYS121 3.5 31.3 1.0 ND1 B:HIS251 3.8 23.1 1.0 CE B:LYS121 4.0 25.2 1.0 CD B:LYS121 4.2 23.7 1.0 NE2 B:HIS251 4.5 23.7 1.0 O B:HOH513 4.6 24.8 1.0 O B:HOH571 5.0 39.6 1.0

K.Shi, A.M.Berghuis. Structural Basis For Dual Nucleotide Selectivity of Aminoglycoside 2''-Phosphotransferase Iva Provides Insight on Determinants of Nucleotide Specificity of Aminoglycoside Kinases. J.Biol.Chem. V. 287 13094 2012.
ISSN: ISSN 0021-9258
PubMed: 22371504
DOI: 10.1074/JBC.M112.349670