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Chlorine in PDB 4dur: The X-Ray Crystal Structure of Full-Length Type II Human Plasminogen

Enzymatic activity of The X-Ray Crystal Structure of Full-Length Type II Human Plasminogen

All present enzymatic activity of The X-Ray Crystal Structure of Full-Length Type II Human Plasminogen:
3.4.21.7;

Protein crystallography data

The structure of The X-Ray Crystal Structure of Full-Length Type II Human Plasminogen, PDB code: 4dur was solved by R.H.P.Law, T.Caradoc-Davies, J.C.Whisstock, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 125.25 / 2.45
Space group P 32 2 1
Cell size a, b, c (Å), α, β, γ (°) 144.620, 144.620, 233.670, 90.00, 90.00, 120.00
R / Rfree (%) 19 / 21.5

Other elements in 4dur:

The structure of The X-Ray Crystal Structure of Full-Length Type II Human Plasminogen also contains other interesting chemical elements:

Potassium (K) 2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the The X-Ray Crystal Structure of Full-Length Type II Human Plasminogen (pdb code 4dur). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 7 binding sites of Chlorine where determined in the The X-Ray Crystal Structure of Full-Length Type II Human Plasminogen, PDB code: 4dur:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; 7;

Chlorine binding site 1 out of 7 in 4dur

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Chlorine binding site 1 out of 7 in the The X-Ray Crystal Structure of Full-Length Type II Human Plasminogen


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of The X-Ray Crystal Structure of Full-Length Type II Human Plasminogen within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl801

b:25.5
occ:1.00
 O A:HOH954 3.0 15.6 1.0
NH2 A:ARG426 3.1 17.2 1.0
N A:ARG68 3.3 22.8 1.0
NZ A:LYS392 3.3 62.4 1.0
CG A:ARG68 3.5 24.6 1.0
CB A:ARG68 3.7 20.2 1.0
CZ A:PHE419 3.7 20.4 1.0
NE A:ARG426 3.8 18.3 1.0
CE1 A:PHE419 3.8 21.3 1.0
CZ A:ARG426 3.9 29.8 1.0
CD1 A:ILE67 3.9 37.3 1.0
CD A:LYS392 3.9 45.5 1.0
CA A:ILE67 4.0 25.9 1.0
CA A:ARG68 4.1 21.8 1.0
C A:ILE67 4.1 27.5 1.0
CD A:ARG68 4.1 26.3 1.0
CE A:LYS392 4.1 53.9 1.0
O A:ILE66 4.3 31.1 1.0
CG1 A:ILE67 4.5 29.9 1.0
CB A:HIS390 4.6 22.5 1.0
O A:HOH1618 4.8 43.5 1.0
CB A:ILE67 4.9 29.4 1.0
N A:ILE67 4.9 26.7 1.0
CE2 A:PHE419 5.0 22.2 1.0

Chlorine binding site 2 out of 7 in 4dur

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Chlorine binding site 2 out of 7 in the The X-Ray Crystal Structure of Full-Length Type II Human Plasminogen


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of The X-Ray Crystal Structure of Full-Length Type II Human Plasminogen within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl802

b:35.4
occ:1.00
 O A:HOH1270 2.9 36.5 1.0
N A:ASN207 3.4 18.2 1.0
CA A:PHE205 3.6 20.0 1.0
CB A:ASN207 3.6 18.1 1.0
C A:PHE205 3.7 23.4 1.0
N A:PRO206 3.7 19.4 1.0
CD A:PRO206 3.7 20.7 1.0
CA A:ASN207 3.9 18.0 1.0
ND2 A:ASN207 3.9 30.1 1.0
CG A:LYS208 4.0 30.8 1.0
CB A:PHE205 4.2 21.6 1.0
N A:LYS208 4.2 17.8 1.0
C A:ASN207 4.2 21.7 1.0
CG A:ASN207 4.3 38.8 1.0
CD1 A:PHE205 4.3 26.2 1.0
O A:PHE205 4.4 23.0 1.0
C A:PRO206 4.5 22.1 1.0
CA A:PRO206 4.6 19.1 1.0
O A:LYS204 4.7 24.0 1.0
CG A:PRO206 4.7 25.3 1.0
CG A:PHE205 4.7 23.1 1.0
N A:PHE205 4.8 20.5 1.0
CE A:LYS208 4.8 48.6 1.0
CB A:LYS208 4.9 18.9 1.0
CD A:LYS208 4.9 39.1 1.0

Chlorine binding site 3 out of 7 in 4dur

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Chlorine binding site 3 out of 7 in the The X-Ray Crystal Structure of Full-Length Type II Human Plasminogen


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of The X-Ray Crystal Structure of Full-Length Type II Human Plasminogen within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl803

b:26.1
occ:1.00
 O A:HOH1290 2.9 21.8 1.0
NE A:ARG234 3.2 28.3 1.0
O A:HOH1292 3.3 33.2 1.0
ND2 A:ASN711 3.3 28.1 1.0
NH2 A:ARG234 3.5 23.4 1.0
N A:LYS708 3.6 17.6 1.0
O A:HOH1291 3.7 35.3 1.0
CA A:LYS708 3.7 17.2 1.0
C A:ASN707 3.8 21.4 1.0
CZ A:ARG234 3.8 34.5 1.0
O A:ASN707 3.9 21.4 1.0
CB A:ASN707 4.1 17.9 1.0
NE1 A:TRP235 4.2 14.7 1.0
CD A:ARG234 4.3 24.9 1.0
CB A:LYS708 4.3 19.0 1.0
CG A:ASN711 4.4 38.0 1.0
CD1 A:TRP235 4.4 15.3 1.0
CB A:ASN711 4.5 21.2 1.0
CA A:ASN707 4.6 17.4 1.0
CG A:LYS708 4.8 24.1 1.0
C A:LYS708 4.9 21.9 1.0

Chlorine binding site 4 out of 7 in 4dur

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Chlorine binding site 4 out of 7 in the The X-Ray Crystal Structure of Full-Length Type II Human Plasminogen


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of The X-Ray Crystal Structure of Full-Length Type II Human Plasminogen within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl804

b:35.6
occ:1.00
 O A:HOH1588 2.9 32.0 1.0
N A:GLU627 3.1 36.7 1.0
N A:HIS621 3.2 23.2 1.0
N A:GLN622 3.3 25.1 1.0
CB A:GLU627 3.7 37.7 1.0
CG A:GLU627 3.7 50.0 1.0
CB A:GLN622 3.7 27.1 1.0
CA A:LEU626 3.8 35.8 1.0
CA A:ALA620 3.8 22.4 1.0
C A:LEU626 3.9 40.3 1.0
CG A:GLN622 3.9 39.0 1.0
CA A:GLU627 4.0 36.5 1.0
CA A:GLN622 4.0 25.4 1.0
C A:ALA620 4.0 26.3 1.0
CG2 A:VAL630 4.1 31.7 1.0
CA A:HIS621 4.1 22.9 1.0
CB A:ALA620 4.2 23.2 1.0
C A:HIS621 4.2 27.5 1.0
O A:GLN622 4.2 28.7 1.0
CD2 A:LEU626 4.2 42.2 1.0
CB A:HIS621 4.3 23.6 1.0
CB A:LEU626 4.5 35.8 1.0
C A:GLN622 4.6 29.8 1.0
O A:ASN625 4.6 38.4 1.0
O A:GLU627 4.7 38.8 1.0
N A:LEU626 4.8 36.0 1.0
O A:GLY619 4.8 25.6 1.0
C A:GLU627 4.9 39.5 1.0
CG A:LEU626 4.9 40.4 1.0
O A:HOH1559 5.0 44.4 1.0

Chlorine binding site 5 out of 7 in 4dur

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Chlorine binding site 5 out of 7 in the The X-Ray Crystal Structure of Full-Length Type II Human Plasminogen


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of The X-Ray Crystal Structure of Full-Length Type II Human Plasminogen within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl801

b:24.8
occ:1.00
 O B:HOH1283 3.0 20.6 1.0
NH2 B:ARG426 3.1 8.8 1.0
NZ B:LYS392 3.3 45.3 1.0
N B:ARG68 3.4 23.2 1.0
CG B:ARG68 3.6 27.4 1.0
CZ B:PHE419 3.6 18.0 1.0
CB B:ARG68 3.8 21.8 1.0
CE1 B:PHE419 3.8 18.9 1.0
CD B:LYS392 3.9 33.3 1.0
CD B:ARG68 3.9 31.0 1.0
NE B:ARG426 4.0 14.1 1.0
CZ B:ARG426 4.0 24.2 1.0
CA B:ILE67 4.1 23.4 1.0
C B:ILE67 4.1 26.2 1.0
CA B:ARG68 4.2 23.2 1.0
CG1 B:ILE67 4.2 28.0 1.0
CE B:LYS392 4.2 38.6 1.0
O B:ILE66 4.5 26.1 1.0
CB B:HIS390 4.5 15.4 1.0
O B:HOH1317 4.6 37.2 1.0
CB B:ILE67 4.8 27.0 1.0
CE2 B:PHE419 4.9 19.9 1.0
O B:HOH1331 4.9 32.3 1.0

Chlorine binding site 6 out of 7 in 4dur

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Chlorine binding site 6 out of 7 in the The X-Ray Crystal Structure of Full-Length Type II Human Plasminogen


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of The X-Ray Crystal Structure of Full-Length Type II Human Plasminogen within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl802

b:25.6
occ:1.00
 O B:HOH1520 3.0 23.1 1.0
NE B:ARG234 3.3 32.1 1.0
ND2 B:ASN711 3.4 23.4 1.0
O B:HOH1448 3.6 32.3 1.0
N B:LYS708 3.7 16.1 1.0
C B:ASN707 3.7 19.7 1.0
CA B:LYS708 3.7 15.8 1.0
O B:ASN707 3.8 19.6 1.0
NH2 B:ARG234 4.0 26.2 1.0
CZ B:ARG234 4.1 41.1 1.0
CB B:ASN707 4.1 16.0 1.0
CD B:ARG234 4.1 25.3 1.0
NE1 B:TRP235 4.2 13.1 1.0
CG B:ASN711 4.4 33.7 1.0
CB B:ASN711 4.4 19.9 1.0
CB B:LYS708 4.4 17.2 1.0
CD1 B:TRP235 4.5 13.6 1.0
CA B:ASN707 4.5 15.6 1.0
C B:LYS708 5.0 20.7 1.0
CG B:LYS708 5.0 22.5 1.0

Chlorine binding site 7 out of 7 in 4dur

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Chlorine binding site 7 out of 7 in the The X-Ray Crystal Structure of Full-Length Type II Human Plasminogen


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 7 of The X-Ray Crystal Structure of Full-Length Type II Human Plasminogen within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl803

b:28.5
occ:1.00
 O B:HOH1338 2.9 37.1 1.0
O B:HOH1321 3.0 28.2 1.0
CA B:PHE205 3.5 17.7 1.0
N B:ASN207 3.6 17.4 1.0
C B:PHE205 3.7 21.8 1.0
CB B:ASN207 3.9 17.8 1.0
N B:PRO206 3.9 18.0 1.0
CG B:LYS208 3.9 24.4 1.0
CB B:PHE205 4.0 19.1 1.0
CA B:ASN207 4.0 17.2 1.0
CD B:PRO206 4.0 19.4 1.0
N B:LYS208 4.1 16.5 1.0
ND2 B:ASN207 4.2 30.1 1.0
C B:ASN207 4.2 20.9 1.0
O B:PHE205 4.3 21.8 1.0
CD1 B:PHE205 4.5 22.9 1.0
CD B:LYS208 4.6 31.9 1.0
CG B:ASN207 4.6 39.3 1.0
CB B:LYS208 4.6 17.7 1.0
C B:PRO206 4.6 20.9 1.0
CE B:LYS208 4.7 42.4 1.0
O B:LYS204 4.7 21.8 1.0
CG B:PHE205 4.8 20.1 1.0
N B:PHE205 4.8 18.4 1.0
CA B:PRO206 4.8 17.7 1.0
CG B:PRO206 4.9 24.0 1.0
CA B:LYS208 4.9 15.8 1.0

Reference:

R.H.P.Law, T.Caradoc-Davies, N.Cowieson, A.J.Horvath, A.J.Quek, J.A.Encarnacao, D.Steer, A.Cowan, Q.Zhang, B.G.C.Lu, R.N.Pike, A.I.Smith, P.B.Coughlin, J.C.Whisstock. The X-Ray Crystal Structure of Full-Length Human Plasminogen Cell Rep V. 1 185 2012.
ISSN: ESSN 2211-1247
PubMed: 22832192
DOI: 10.1016/J.CELREP.2012.02.012
Page generated: Sun Jul 21 12:19:34 2024

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