Chlorine in PDB 4e0w: Crystal Structure of the Kainate Receptor GLUK3 Ligand Binding Domain in Complex with Kainate

The structure of Crystal Structure of the Kainate Receptor GLUK3 Ligand Binding Domain in Complex with Kainate, PDB code: 4e0w was solved by R.Venskutonyte, K.Frydenvang, J.S.Kastrup, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	48.48 / 2.35
Space group	P 41 2 2
Cell size a, b, c (Å), α, β, γ (°)	68.558, 68.558, 126.883, 90.00, 90.00, 90.00
R / Rfree (%)	17.9 / 23.2

The structure of Crystal Structure of the Kainate Receptor GLUK3 Ligand Binding Domain in Complex with Kainate also contains other interesting chemical elements:

Potassium

(K)

2 atoms

The binding sites of Chlorine atom in the Crystal Structure of the Kainate Receptor GLUK3 Ligand Binding Domain in Complex with Kainate (pdb code 4e0w). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of the Kainate Receptor GLUK3 Ligand Binding Domain in Complex with Kainate, PDB code: 4e0w:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Crystal Structure of the Kainate Receptor GLUK3 Ligand Binding Domain in Complex with Kainate


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of the Kainate Receptor GLUK3 Ligand Binding Domain in Complex with Kainate within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl302 b:48.4 occ:1.00 N A:LEU57 3.4 28.4 1.0 NH2 A:ARG33 3.6 18.6 1.0 NH1 A:ARG33 3.6 27.1 1.0 CA A:ARG56 3.8 29.1 1.0 CZ A:ARG33 4.0 22.4 1.0 C A:ARG56 4.1 31.2 1.0 O A:HOH458 4.1 47.8 1.0 O A:ILE55 4.2 28.9 1.0 CB A:LEU57 4.2 31.6 1.0 CG A:LEU57 4.3 37.6 1.0 CD1 A:LEU57 4.4 27.1 1.0 CA A:LEU57 4.4 29.3 1.0 CB A:ARG56 4.4 35.6 1.0 O A:LEU57 4.8 39.7 1.0 CG A:ARG56 4.8 44.8 1.0 N A:ARG56 4.8 30.9 1.0 C A:ILE55 4.9 24.5 1.0 CZ A:PHE34 5.0 27.7 1.0

Chlorine binding site 2 out of 2 in the Crystal Structure of the Kainate Receptor GLUK3 Ligand Binding Domain in Complex with Kainate


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of the Kainate Receptor GLUK3 Ligand Binding Domain in Complex with Kainate within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl303 b:46.4 occ:1.00 O A:HOH499 3.2 41.9 1.0 N A:HIS245 3.2 25.0 1.0 N A:LEU244 3.3 27.2 1.0 CA A:ASP242 3.4 32.6 1.0 CB A:LEU244 3.5 29.4 1.0 O A:GLN239 3.5 32.8 1.0 CA A:GLN239 3.6 32.2 1.0 C A:ASP242 3.6 36.8 1.0 CA A:LEU244 3.7 32.5 1.0 N A:LYS243 3.8 20.0 1.0 C A:LEU244 3.9 31.2 1.0 CG A:GLN239 4.0 47.0 1.0 CB A:HIS245 4.0 33.9 1.0 C A:GLN239 4.0 31.6 1.0 N A:ASP242 4.1 30.9 1.0 CA A:HIS245 4.1 34.0 1.0 O A:ASP242 4.2 41.1 1.0 CB A:GLN239 4.2 26.8 1.0 O A:LEU238 4.2 33.9 1.0 C A:LYS243 4.3 25.5 1.0 CG A:LEU244 4.4 28.2 1.0 OD1 A:ASP242 4.4 60.5 1.0 CB A:ASP242 4.5 50.7 1.0 N A:GLN239 4.5 26.0 1.0 CA A:LYS243 4.7 22.9 1.0 C A:LEU238 4.8 35.4 1.0 CG A:ASP242 5.0 62.8 1.0 CD1 A:LEU244 5.0 29.6 1.0

R.Venskutonyte, K.Frydenvang, H.Hald, A.C.Rabassa, M.Gajhede, P.K.Ahring, J.S.Kastrup. Kainate Induces Various Domain Closures in Ampa and Kainate Receptors. Neurochem Int V. 61 536 2012.
ISSN: ESSN 1872-9754
PubMed: 22425692
DOI: 10.1016/J.NEUINT.2012.02.016