Chlorine in PDB 4ekd: Structure of Human Regulator of G Protein Signaling 2 (RGS2) in Complex with Murine Galpha-Q(R183C)

All present enzymatic activity of Structure of Human Regulator of G Protein Signaling 2 (RGS2) in Complex with Murine Galpha-Q(R183C):
3.6.5.1;

The structure of Structure of Human Regulator of G Protein Signaling 2 (RGS2) in Complex with Murine Galpha-Q(R183C), PDB code: 4ekd was solved by J.J.G.Tesmer, M.R.Nance, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.98 / 2.71
Space group	P 41 21 2
Cell size a, b, c (Å), α, β, γ (°)	60.248, 60.248, 345.569, 90.00, 90.00, 90.00
R / Rfree (%)	19 / 25.2

The structure of Structure of Human Regulator of G Protein Signaling 2 (RGS2) in Complex with Murine Galpha-Q(R183C) also contains other interesting chemical elements:

Fluorine	(F)	4 atoms
Cobalt	(Co)	2 atoms
Magnesium	(Mg)	1 atom
Aluminium	(Al)	1 atom

The binding sites of Chlorine atom in the Structure of Human Regulator of G Protein Signaling 2 (RGS2) in Complex with Murine Galpha-Q(R183C) (pdb code 4ekd). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Structure of Human Regulator of G Protein Signaling 2 (RGS2) in Complex with Murine Galpha-Q(R183C), PDB code: 4ekd:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Structure of Human Regulator of G Protein Signaling 2 (RGS2) in Complex with Murine Galpha-Q(R183C)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of Human Regulator of G Protein Signaling 2 (RGS2) in Complex with Murine Galpha-Q(R183C) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl404 b:0.7 occ:1.00 CO A:CO403 2.5 95.1 1.0 NE2 A:HIS109 2.9 0.1 1.0 CL A:CL405 3.0 96.6 1.0 CE1 A:HIS109 3.4 0.3 1.0 CD2 A:HIS109 4.0 0.6 1.0 NE2 A:HIS105 4.2 0.6 1.0 CB A:ALA130 4.5 1.0 1.0 ND1 A:HIS109 4.6 0.9 1.0 CD2 A:HIS105 4.8 99.4 1.0 CG A:HIS109 4.9 0.1 1.0

Chlorine binding site 2 out of 2 in the Structure of Human Regulator of G Protein Signaling 2 (RGS2) in Complex with Murine Galpha-Q(R183C)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Structure of Human Regulator of G Protein Signaling 2 (RGS2) in Complex with Murine Galpha-Q(R183C) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl405 b:96.6 occ:1.00 CO A:CO403 2.5 95.1 1.0 CL A:CL404 3.0 0.7 1.0 NE2 A:HIS109 3.3 0.1 1.0 CD2 A:HIS109 3.3 0.6 1.0 NE2 A:HIS105 3.6 0.6 1.0 CE1 A:HIS105 4.1 0.7 1.0 CE1 A:HIS109 4.4 0.3 1.0 CG A:HIS109 4.5 0.1 1.0 CD2 A:HIS105 4.6 99.4 1.0

M.R.Nance, B.Kreutz, V.M.Tesmer, R.Sterne-Marr, T.Kozasa, J.J.Tesmer. Structural and Functional Analysis of the Regulator of G Protein Signaling 2-G Alpha Q Complex. Structure V. 21 438 2013.
ISSN: ISSN 0969-2126
PubMed: 23434405
DOI: 10.1016/J.STR.2012.12.016