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Chlorine in PDB 4eu1: Structure of A Mitochondrial Aspartate Aminotransferase From Trypanosoma Brucei

Enzymatic activity of Structure of A Mitochondrial Aspartate Aminotransferase From Trypanosoma Brucei

All present enzymatic activity of Structure of A Mitochondrial Aspartate Aminotransferase From Trypanosoma Brucei:
2.6.1.1;

Protein crystallography data

The structure of Structure of A Mitochondrial Aspartate Aminotransferase From Trypanosoma Brucei, PDB code: 4eu1 was solved by Seattle Structural Genomics Center For Infectious Disease (Ssgcid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.00 / 2.30
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 62.260, 96.250, 81.320, 90.00, 111.62, 90.00
R / Rfree (%) 19.6 / 24.5

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Structure of A Mitochondrial Aspartate Aminotransferase From Trypanosoma Brucei (pdb code 4eu1). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 5 binding sites of Chlorine where determined in the Structure of A Mitochondrial Aspartate Aminotransferase From Trypanosoma Brucei, PDB code: 4eu1:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5;

Chlorine binding site 1 out of 5 in 4eu1

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Chlorine binding site 1 out of 5 in the Structure of A Mitochondrial Aspartate Aminotransferase From Trypanosoma Brucei


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of A Mitochondrial Aspartate Aminotransferase From Trypanosoma Brucei within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl401

b:41.0
occ:1.00
 NH2 A:ARG185 2.9 33.0 0.5
NH2 A:ARG185 3.0 33.1 0.5
ND1 A:HIS181 3.1 24.5 1.0
CE1 A:PHE217 3.2 22.4 1.0
CD1 A:PHE217 3.6 21.7 1.0
CG A:HIS181 3.9 24.4 1.0
CZ A:PHE217 3.9 22.4 1.0
CB A:HIS181 3.9 24.8 1.0
CZ A:ARG185 4.1 32.0 0.5
CE1 A:HIS181 4.1 24.2 1.0
O A:HOH584 4.1 30.7 1.0
CZ A:ARG185 4.1 32.6 0.5
NH1 A:ARG185 4.5 31.1 0.5
CG A:PHE217 4.6 21.1 1.0
NE A:ARG185 4.7 32.1 0.5
CE2 A:PHE217 4.8 21.6 1.0

Chlorine binding site 2 out of 5 in 4eu1

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Chlorine binding site 2 out of 5 in the Structure of A Mitochondrial Aspartate Aminotransferase From Trypanosoma Brucei


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Structure of A Mitochondrial Aspartate Aminotransferase From Trypanosoma Brucei within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl402

b:59.6
occ:1.00
 NH1 A:ARG315 3.3 35.3 1.0
CG A:ARG315 4.0 30.5 1.0
O A:HOH634 4.1 27.3 1.0
CB A:ARG315 4.2 28.8 1.0
CD A:ARG315 4.2 31.8 1.0
N A:SER373 4.4 37.8 1.0
CZ A:ARG315 4.4 34.8 1.0
CG2 A:VAL312 4.4 26.8 1.0
CA A:SER373 4.5 38.7 1.0
OG A:SER373 4.5 40.5 1.0
CG1 A:VAL376 4.7 34.0 1.0
CA A:VAL312 4.7 25.8 1.0
C A:ASN372 4.7 36.2 1.0
NE A:ARG315 4.8 33.5 1.0
CB A:VAL312 4.8 25.9 1.0
O A:GLU311 5.0 26.7 1.0

Chlorine binding site 3 out of 5 in 4eu1

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Chlorine binding site 3 out of 5 in the Structure of A Mitochondrial Aspartate Aminotransferase From Trypanosoma Brucei


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Structure of A Mitochondrial Aspartate Aminotransferase From Trypanosoma Brucei within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl403

b:49.0
occ:1.00
 OH A:TYR30 3.5 28.0 1.0
CZ A:PHE38 4.2 31.0 1.0
CE2 A:TYR30 4.2 27.5 1.0
CE2 A:PHE38 4.2 29.5 1.0
CB A:ASP32 4.3 31.0 1.0
CE1 A:PHE38 4.3 31.8 1.0
CZ A:TYR30 4.3 27.5 1.0
CD2 A:PHE38 4.5 29.3 1.0
CB A:GLN304 4.6 33.8 1.0
CD1 A:PHE38 4.6 31.4 1.0
CG A:PHE38 4.6 29.9 1.0
OE1 A:GLN304 4.7 35.5 1.0
CA A:ASP32 4.7 30.3 1.0
CG A:MET305 4.7 26.8 1.0
O A:GLN304 4.7 30.1 1.0
C A:GLN304 4.8 29.8 1.0
N A:MET305 4.9 28.3 1.0
CA A:MET305 4.9 27.4 1.0
CD A:ARG308 5.0 33.4 1.0

Chlorine binding site 4 out of 5 in 4eu1

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Chlorine binding site 4 out of 5 in the Structure of A Mitochondrial Aspartate Aminotransferase From Trypanosoma Brucei


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Structure of A Mitochondrial Aspartate Aminotransferase From Trypanosoma Brucei within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl401

b:34.6
occ:1.00
 NH2 B:ARG185 2.8 32.4 0.5
CE1 B:PHE217 3.3 24.2 1.0
NH2 B:ARG185 3.4 34.0 0.5
ND1 B:HIS181 3.5 22.6 1.0
NH1 B:ARG185 3.6 32.6 0.5
CD1 B:PHE217 3.8 23.4 1.0
CZ B:ARG185 3.9 33.4 0.5
CZ B:PHE217 4.1 24.0 1.0
CZ B:ARG185 4.1 32.4 0.5
CG B:HIS181 4.4 22.5 1.0
CB B:HIS181 4.4 23.4 1.0
CE1 B:HIS181 4.5 22.2 1.0
NE B:ARG185 4.7 31.8 0.5
CG B:PHE217 4.8 22.6 1.0
NH1 B:ARG185 5.0 33.1 0.5

Chlorine binding site 5 out of 5 in 4eu1

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Chlorine binding site 5 out of 5 in the Structure of A Mitochondrial Aspartate Aminotransferase From Trypanosoma Brucei


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Structure of A Mitochondrial Aspartate Aminotransferase From Trypanosoma Brucei within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl402

b:62.3
occ:1.00
 NH1 B:ARG315 3.5 30.4 1.0
O B:HOH572 3.7 19.7 1.0
N B:SER373 4.2 30.8 1.0
CG B:ARG315 4.3 26.6 1.0
CG2 B:VAL312 4.3 23.9 1.0
OG B:SER373 4.4 34.7 1.0
CA B:SER373 4.4 32.7 1.0
CB B:ARG315 4.4 25.2 1.0
CD B:ARG315 4.5 28.3 1.0
C B:ASN372 4.6 29.1 1.0
CA B:VAL312 4.6 23.6 1.0
CZ B:ARG315 4.6 30.2 1.0
CB B:VAL312 4.7 23.1 1.0
CG1 B:VAL376 4.7 28.7 1.0
OD1 B:ASP33 4.8 30.5 1.0
CG B:GLU311 4.8 35.6 1.0
CB B:SER373 4.9 34.5 1.0
O B:ASN372 5.0 29.0 1.0

Reference:

J.Abendroth, R.Choi, A.Wall, M.C.Clifton, C.M.Lukacs, B.L.Staker, W.Van Voorhis, P.Myler, D.D.Lorimer, T.E.Edwards. Structures of Aspartate Aminotransferases From Trypanosoma Brucei, Leishmania Major and Giardia Lamblia. Acta Crystallogr F Struct V. 71 566 2015BIOL Commun.
ISSN: ISSN 1744-3091
PubMed: 25945710
DOI: 10.1107/S2053230X15001831
Page generated: Sat Dec 12 10:35:38 2020

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