Atomistry » Chlorine » PDB 4eu6-4f1a » 4eyp
Atomistry »
  Chlorine »
    PDB 4eu6-4f1a »
      4eyp »

Chlorine in PDB 4eyp: Human Insulin

Protein crystallography data

The structure of Human Insulin, PDB code: 4eyp was solved by M.P.Favero-Retto, L.C.Palmieri, L.M.T.R.Lima, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 41.07 / 1.59
Space group H 3
Cell size a, b, c (Å), α, β, γ (°) 82.150, 82.150, 33.680, 90.00, 90.00, 120.00
R / Rfree (%) 14.2 / 22.3

Other elements in 4eyp:

The structure of Human Insulin also contains other interesting chemical elements:

Zinc (Zn) 2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Human Insulin (pdb code 4eyp). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Human Insulin, PDB code: 4eyp:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in 4eyp

Go back to Chlorine Binding Sites List in 4eyp
Chlorine binding site 1 out of 2 in the Human Insulin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Human Insulin within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl102

b:16.2
occ:0.25
ZN B:ZN101 3.3 6.7 0.2
O B:HOH224 3.5 35.6 1.0
NE2 B:HIS10 4.4 7.6 1.0
CD2 B:HIS10 4.6 7.5 1.0

Chlorine binding site 2 out of 2 in 4eyp

Go back to Chlorine Binding Sites List in 4eyp
Chlorine binding site 2 out of 2 in the Human Insulin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Human Insulin within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cl102

b:28.0
occ:0.30
ZN D:ZN101 2.3 9.3 0.3
O D:HOH223 2.7 19.8 1.0
NE2 D:HIS10 3.4 6.6 1.0
O D:HOH207 3.6 32.3 1.0
CD2 D:HIS10 3.9 6.7 1.0
O D:HOH243 4.4 6.9 0.3
CE1 D:HIS10 4.5 10.3 1.0
O D:HOH239 4.7 24.3 1.0

Reference:

M.P.Favero-Retto, L.C.Palmieri, T.A.Souza, F.C.Almeida, L.M.Lima. Structural Meta-Analysis of Regular Human Insulin in Pharmaceutical Formulations. Eur J Pharm Biopharm V. 85 1112 2013.
ISSN: ISSN 0939-6411
PubMed: 23692694
DOI: 10.1016/J.EJPB.2013.05.005
Page generated: Sun Jul 21 13:27:29 2024

Last articles

Cl in 3VSX
Cl in 3VS7
Cl in 3VS6
Cl in 3VSJ
Cl in 3VS4
Cl in 3VS3
Cl in 3VS2
Cl in 3VS1
Cl in 3VRA
Cl in 3VRZ
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy