Atomistry » Chlorine » PDB 4eu6-4f1a » 4f0y
Atomistry »
  Chlorine »
    PDB 4eu6-4f1a »
      4f0y »

Chlorine in PDB 4f0y: Crystal Structure of Aminoglycoside Antibiotic 6'-N-Acetyltransferase Aac(6')-Ig From Acinetobacter Haemolyticus, Apo

Enzymatic activity of Crystal Structure of Aminoglycoside Antibiotic 6'-N-Acetyltransferase Aac(6')-Ig From Acinetobacter Haemolyticus, Apo

All present enzymatic activity of Crystal Structure of Aminoglycoside Antibiotic 6'-N-Acetyltransferase Aac(6')-Ig From Acinetobacter Haemolyticus, Apo:
2.3.1.82;

Protein crystallography data

The structure of Crystal Structure of Aminoglycoside Antibiotic 6'-N-Acetyltransferase Aac(6')-Ig From Acinetobacter Haemolyticus, Apo, PDB code: 4f0y was solved by P.J.Stogios, E.Evdokimova, A.Dong, G.Minasov, V.Yim, P.Courvalin, A.Savchenko, W.F.Anderson, Center For Structural Genomics Ofinfectious Diseases (Csgid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 24.07 / 2.56
Space group P 1
Cell size a, b, c (Å), α, β, γ (°) 37.963, 44.018, 46.576, 83.19, 87.44, 72.65
R / Rfree (%) 18.1 / 24

Other elements in 4f0y:

The structure of Crystal Structure of Aminoglycoside Antibiotic 6'-N-Acetyltransferase Aac(6')-Ig From Acinetobacter Haemolyticus, Apo also contains other interesting chemical elements:

Magnesium (Mg) 2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Aminoglycoside Antibiotic 6'-N-Acetyltransferase Aac(6')-Ig From Acinetobacter Haemolyticus, Apo (pdb code 4f0y). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Crystal Structure of Aminoglycoside Antibiotic 6'-N-Acetyltransferase Aac(6')-Ig From Acinetobacter Haemolyticus, Apo, PDB code: 4f0y:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in 4f0y

Go back to Chlorine Binding Sites List in 4f0y
Chlorine binding site 1 out of 3 in the Crystal Structure of Aminoglycoside Antibiotic 6'-N-Acetyltransferase Aac(6')-Ig From Acinetobacter Haemolyticus, Apo


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Aminoglycoside Antibiotic 6'-N-Acetyltransferase Aac(6')-Ig From Acinetobacter Haemolyticus, Apo within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl202

b:62.9
occ:1.00
 N A:ALA85 3.4 40.6 1.0
CB A:ALA85 3.6 44.6 1.0
CD A:PRO84 3.6 39.9 1.0
CB A:LEU83 3.8 37.5 1.0
N A:PRO84 3.8 41.9 1.0
CA A:ALA85 4.1 44.7 1.0
CB A:PRO84 4.1 37.0 1.0
C A:LEU83 4.1 37.1 1.0
CG A:PRO84 4.2 37.7 1.0
C A:PRO84 4.3 42.0 1.0
CA A:PRO84 4.4 39.4 1.0
CA A:LEU83 4.4 34.9 1.0
CD2 A:LEU83 4.4 38.2 1.0
CG A:LEU83 4.4 38.5 1.0
CD1 A:LEU83 4.4 36.3 1.0
O A:LEU83 4.8 32.8 1.0
ND1 A:HIS86 5.0 41.4 1.0

Chlorine binding site 2 out of 3 in 4f0y

Go back to Chlorine Binding Sites List in 4f0y
Chlorine binding site 2 out of 3 in the Crystal Structure of Aminoglycoside Antibiotic 6'-N-Acetyltransferase Aac(6')-Ig From Acinetobacter Haemolyticus, Apo


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Aminoglycoside Antibiotic 6'-N-Acetyltransferase Aac(6')-Ig From Acinetobacter Haemolyticus, Apo within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl202

b:68.5
occ:1.00
 N B:ILE80 3.1 33.7 1.0
CA B:GLY79 3.5 31.4 1.0
O B:HOH308 3.6 19.2 1.0
O B:ILE80 3.6 39.6 1.0
O B:HOH338 3.7 29.8 1.0
CG2 B:ILE80 3.8 28.8 1.0
C B:GLY79 3.8 34.0 1.0
O B:HOH337 3.8 32.9 1.0
CA B:ILE80 4.1 33.3 1.0
C B:ILE80 4.3 35.7 1.0
CD1 B:LEU21 4.4 26.3 1.0
OG B:SER122 4.5 26.9 1.0
CE1 B:HIS126 4.6 27.2 1.0
CB B:ILE80 4.6 26.8 1.0
N B:GLY79 4.6 32.5 1.0
O B:GLY79 5.0 36.8 1.0
O B:GLU78 5.0 33.0 1.0

Chlorine binding site 3 out of 3 in 4f0y

Go back to Chlorine Binding Sites List in 4f0y
Chlorine binding site 3 out of 3 in the Crystal Structure of Aminoglycoside Antibiotic 6'-N-Acetyltransferase Aac(6')-Ig From Acinetobacter Haemolyticus, Apo


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of Aminoglycoside Antibiotic 6'-N-Acetyltransferase Aac(6')-Ig From Acinetobacter Haemolyticus, Apo within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl203

b:57.0
occ:1.00
 O B:HOH308 2.9 19.2 1.0
N B:ALA116 3.0 21.2 1.0
ND2 B:ASN119 3.1 26.6 1.0
CA B:ALA115 3.7 22.6 1.0
CB B:ALA116 3.8 9.2 1.0
C B:ALA115 3.8 23.0 1.0
CB B:ASN119 3.9 29.1 1.0
CB B:ALA115 3.9 20.4 1.0
CG B:ASN119 4.0 29.5 1.0
CA B:ALA116 4.0 20.8 1.0
O B:HOH337 4.1 32.9 1.0
O B:HOH333 4.2 24.8 1.0
O B:HOH338 4.5 29.8 1.0
OG B:SER122 4.7 26.9 1.0
CB B:SER122 4.7 26.8 1.0
O B:ALA116 4.9 14.9 1.0
O B:ASP114 4.9 30.3 1.0
N B:ALA115 5.0 25.7 1.0
C B:ALA116 5.0 19.6 1.0

Reference:

P.J.Stogios, M.L.Kuhn, E.Evdokimova, M.Law, P.Courvalin, A.Savchenko. Structural and Biochemical Characterization of Acinetobacter Spp. Aminoglycoside Acetyltransferases Highlights Functional and Evolutionary Variation Among Antibiotic Resistance Enzymes. Acs Infect Dis. V. 3 132 2017.
ISSN: ESSN 2373-8227
PubMed: 27785912
DOI: 10.1021/ACSINFECDIS.6B00058
Page generated: Sun Jul 21 13:29:04 2024

Last articles

Zn in 9J0N
Zn in 9J0O
Zn in 9J0P
Zn in 9FJX
Zn in 9EKB
Zn in 9C0F
Zn in 9CAH
Zn in 9CH0
Zn in 9CH3
Zn in 9CH1
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy