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Chlorine in PDB 4f4t: Human Insulin

Protein crystallography data

The structure of Human Insulin, PDB code: 4f4t was solved by M.P.Favero-Retto, L.C.Palmieri, L.M.T.R.Lima, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 24.44 / 1.64
Space group H 3
Cell size a, b, c (Å), α, β, γ (°) 81.860, 81.860, 33.750, 90.00, 90.00, 120.00
R / Rfree (%) 17 / 21.4

Other elements in 4f4t:

The structure of Human Insulin also contains other interesting chemical elements:

Zinc (Zn) 2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Human Insulin (pdb code 4f4t). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Human Insulin, PDB code: 4f4t:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in 4f4t

Go back to Chlorine Binding Sites List in 4f4t
Chlorine binding site 1 out of 2 in the Human Insulin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Human Insulin within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl102

b:26.5
occ:0.33
ZN B:ZN101 3.0 10.1 0.3
NE2 B:HIS10 4.2 9.4 1.0
CD2 B:HIS10 4.5 8.8 1.0

Chlorine binding site 2 out of 2 in 4f4t

Go back to Chlorine Binding Sites List in 4f4t
Chlorine binding site 2 out of 2 in the Human Insulin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Human Insulin within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cl102

b:29.0
occ:0.33
ZN D:ZN101 2.3 8.8 0.3
O D:HOH234 2.7 22.2 1.0
O D:HOH220 3.3 26.1 1.0
NE2 D:HIS10 3.5 7.8 1.0
CD2 D:HIS10 4.0 6.8 1.0
CE1 D:HIS10 4.6 10.0 1.0

Reference:

M.P.Favero-Retto, L.C.Palmieri, T.A.Souza, F.C.Almeida, L.M.Lima. Structural Meta-Analysis of Regular Human Insulin in Pharmaceutical Formulations. Eur J Pharm Biopharm V. 85 1112 2013.
PubMed: 23692694
DOI: 10.1016/J.EJPB.2013.05.005
Page generated: Fri Jul 11 15:08:04 2025

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