Chlorine in PDB 4fbe: Crystal Structure of the C136A/C164A Variant of Mitochondrial Isoform of Glutaminyl Cyclase From Drosophila Melanogaster

Enzymatic activity of Crystal Structure of the C136A/C164A Variant of Mitochondrial Isoform of Glutaminyl Cyclase From Drosophila Melanogaster

All present enzymatic activity of Crystal Structure of the C136A/C164A Variant of Mitochondrial Isoform of Glutaminyl Cyclase From Drosophila Melanogaster:
2.3.2.5;

Protein crystallography data

The structure of Crystal Structure of the C136A/C164A Variant of Mitochondrial Isoform of Glutaminyl Cyclase From Drosophila Melanogaster, PDB code: 4fbe was solved by P.Kolenko, B.Koch, D.Ruiz-Carilo, M.T.Stubbs, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	71.66 / 1.88
*Space group*	P 1
*Cell size a, b, c (Å), α, β, γ (°)*	45.928, 46.436, 74.150, 84.93, 75.17, 74.47
*R / R_free (%)*	17.1 / 22.3

Other elements in 4fbe:

The structure of Crystal Structure of the C136A/C164A Variant of Mitochondrial Isoform of Glutaminyl Cyclase From Drosophila Melanogaster also contains other interesting chemical elements:

Zinc

(Zn)

2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of the C136A/C164A Variant of Mitochondrial Isoform of Glutaminyl Cyclase From Drosophila Melanogaster (pdb code 4fbe). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of the C136A/C164A Variant of Mitochondrial Isoform of Glutaminyl Cyclase From Drosophila Melanogaster, PDB code: 4fbe:

Chlorine binding site 1 out of 1 in 4fbe

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Chlorine Binding Sites List in 4fbe

Chlorine binding site 1 out of 1 in the Crystal Structure of the C136A/C164A Variant of Mitochondrial Isoform of Glutaminyl Cyclase From Drosophila Melanogaster

Mono view

Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of the C136A/C164A Variant of Mitochondrial Isoform of Glutaminyl Cyclase From Drosophila Melanogaster within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Cl402 b:21.9 occ:1.00	O	B:HOH588	3.0	19.7	1.0
	O	A:HOH618	3.0	19.7	1.0
	N	A:ASN81	3.3	15.0	1.0
	CG	A:ASN81	3.4	15.8	1.0
	ND2	B:ASN81	3.6	14.1	1.0
	OD1	A:ASN81	3.6	16.8	1.0
	CB	A:ASN81	3.6	15.4	1.0
	OE2	B:GLU147	3.7	18.5	1.0
	CG	B:PRO74	3.8	13.3	1.0
	N	A:THR80	3.8	15.8	1.0
	ND2	A:ASN81	3.9	16.4	1.0
	CB	A:THR80	3.9	15.4	1.0
	CD	B:PRO74	4.0	13.1	1.0
	CA	A:ASN81	4.0	15.2	1.0
	CB	A:THR79	4.0	16.8	1.0
	CA	A:THR80	4.1	15.4	1.0
	C	A:THR80	4.1	15.1	1.0
	CB	B:PRO74	4.4	13.6	1.0
	OG1	A:THR79	4.5	16.6	1.0
	O	A:HOH623	4.5	27.9	1.0
	C	A:THR79	4.5	16.6	1.0
	CD	B:GLU147	4.6	17.9	1.0
	CG	B:ASN81	4.6	14.2	1.0
	CA	A:THR79	4.8	16.6	1.0
	OG1	A:THR80	4.8	14.7	1.0
	CG2	A:THR80	4.8	15.4	1.0
	CG2	A:THR79	4.9	16.7	1.0
	O	A:HOH518	4.9	10.9	1.0
	O	A:PRO74	5.0	14.6	1.0

Reference:

B.Koch, P.Kolenko, M.Buchholz, D.Ruiz Carrillo, C.Parthier, M.Wermann, J.U.Rahfeld, G.Reuter, S.Schilling, M.T.Stubbs, H.U.Demuth. Crystal Structures of Glutaminyl Cyclases (Qcs) From Drosophila Melanogaster Reveal Active Site Conservation Between Insect and Mammalian Qcs. Biochemistry V. 51 7383 2012.
ISSN: ISSN 0006-2960
PubMed: 22897232
DOI: 10.1021/BI300687G

Page generated: Sun Jul 21 13:37:33 2024

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