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Chlorine in PDB 4ffs: Crystal Structure of 5'-Methylthioadenosine/S-Adenosylhomocysteine Nucleosidase From Helicobacter Pylori with Butyl-Thio-Dadme- Immucillin-A

Enzymatic activity of Crystal Structure of 5'-Methylthioadenosine/S-Adenosylhomocysteine Nucleosidase From Helicobacter Pylori with Butyl-Thio-Dadme- Immucillin-A

All present enzymatic activity of Crystal Structure of 5'-Methylthioadenosine/S-Adenosylhomocysteine Nucleosidase From Helicobacter Pylori with Butyl-Thio-Dadme- Immucillin-A:
3.2.2.9;

Protein crystallography data

The structure of Crystal Structure of 5'-Methylthioadenosine/S-Adenosylhomocysteine Nucleosidase From Helicobacter Pylori with Butyl-Thio-Dadme- Immucillin-A, PDB code: 4ffs was solved by A.M.Haapalainen, A.Rinaldo-Matthis, R.L.Brown, G.E.Norris, S.C.Almo, V.L.Schramm, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 42.19 / 1.90
Space group I 4 3 2
Cell size a, b, c (Å), α, β, γ (°) 157.732, 157.732, 157.732, 90.00, 90.00, 90.00
R / Rfree (%) 16.1 / 19.2

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of 5'-Methylthioadenosine/S-Adenosylhomocysteine Nucleosidase From Helicobacter Pylori with Butyl-Thio-Dadme- Immucillin-A (pdb code 4ffs). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of 5'-Methylthioadenosine/S-Adenosylhomocysteine Nucleosidase From Helicobacter Pylori with Butyl-Thio-Dadme- Immucillin-A, PDB code: 4ffs:

Chlorine binding site 1 out of 1 in 4ffs

Go back to Chlorine Binding Sites List in 4ffs
Chlorine binding site 1 out of 1 in the Crystal Structure of 5'-Methylthioadenosine/S-Adenosylhomocysteine Nucleosidase From Helicobacter Pylori with Butyl-Thio-Dadme- Immucillin-A


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of 5'-Methylthioadenosine/S-Adenosylhomocysteine Nucleosidase From Helicobacter Pylori with Butyl-Thio-Dadme- Immucillin-A within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl302

b:37.6
occ:1.00
 O A:HOH607 2.8 17.5 1.0
N A:ASP24 3.0 19.7 1.0
CB A:VAL23 3.5 18.2 1.0
CA A:VAL23 3.5 18.3 1.0
C A:VAL23 3.7 19.5 1.0
CB A:ASP24 3.8 22.7 1.0
OD2 A:ASP24 3.8 27.0 1.0
O A:HOH401 3.9 21.9 1.0
O A:HOH608 3.9 22.1 1.0
CA A:ASP24 4.0 21.1 1.0
CG A:ASP24 4.0 24.8 1.0
CG1 A:VAL23 4.0 18.4 1.0
O A:ASP24 4.5 20.5 1.0
CG2 A:VAL23 4.7 18.0 1.0
C A:ASP24 4.8 21.1 1.0
OD1 A:ASP24 4.9 27.8 1.0
O A:VAL23 4.9 20.6 1.0
N A:VAL23 4.9 19.3 1.0

Reference:

S.Wang, A.M.Haapalainen, F.Yan, Q.Du, P.C.Tyler, G.B.Evans, A.Rinaldo-Matthis, R.L.Brown, G.E.Norris, S.C.Almo, V.L.Schramm. A Picomolar Transition State Analogue Inhibitor of Mtan As A Specific Antibiotic For Helicobacter Pylori. Biochemistry V. 51 6892 2012.
ISSN: ISSN 0006-2960
PubMed: 22891633
DOI: 10.1021/BI3009664
Page generated: Sat Dec 12 10:37:00 2020

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