Chlorine in PDB 4fz0: Crystal Structure of Acid-Sensing Ion Channel in Complex with Psalmotoxin 1 at Low pH

The structure of Crystal Structure of Acid-Sensing Ion Channel in Complex with Psalmotoxin 1 at Low pH, PDB code: 4fz0 was solved by I.Baconguis, E.Gouaux, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	38.37 / 2.80
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	232.290, 108.710, 126.360, 90.00, 119.78, 90.00
R / Rfree (%)	20.2 / 23.1

The binding sites of Chlorine atom in the Crystal Structure of Acid-Sensing Ion Channel in Complex with Psalmotoxin 1 at Low pH (pdb code 4fz0). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Crystal Structure of Acid-Sensing Ion Channel in Complex with Psalmotoxin 1 at Low pH, PDB code: 4fz0:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in the Crystal Structure of Acid-Sensing Ion Channel in Complex with Psalmotoxin 1 at Low pH


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Acid-Sensing Ion Channel in Complex with Psalmotoxin 1 at Low pH within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl501 b:81.6 occ:1.00 NE A:ARG310 3.1 43.6 1.0 OE2 A:GLU314 3.3 62.4 1.0 NH1 A:ARG310 3.5 47.3 1.0 CG1 A:VAL353 3.6 59.1 1.0 CZ A:ARG310 3.8 44.7 1.0 NZ B:LYS212 3.8 60.1 1.0 CB A:ARG310 3.9 51.3 1.0 CG A:ARG310 4.0 51.2 1.0 CG A:GLU314 4.1 47.3 1.0 CD A:ARG310 4.1 41.5 1.0 CD A:GLU314 4.2 64.0 1.0 CB A:VAL353 4.4 58.4 1.0 CE B:LYS212 4.5 68.3 1.0 CA A:VAL353 4.5 58.3 1.0 O A:ARG310 4.6 57.1 1.0 CA A:ARG310 4.6 53.9 1.0 CD B:LYS212 4.8 67.1 1.0 CB A:CYS360 4.9 59.3 1.0 CD2 A:LEU352 4.9 42.2 1.0 C A:ARG310 4.9 52.4 1.0 CG A:LEU352 5.0 42.1 1.0

Chlorine binding site 2 out of 3 in the Crystal Structure of Acid-Sensing Ion Channel in Complex with Psalmotoxin 1 at Low pH


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Acid-Sensing Ion Channel in Complex with Psalmotoxin 1 at Low pH within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl501 b:71.8 occ:1.00 NE B:ARG310 3.2 39.7 1.0 OE2 B:GLU314 3.3 55.3 1.0 CG1 B:VAL353 3.4 56.0 1.0 NH1 B:ARG310 3.5 47.6 1.0 CZ B:ARG310 3.8 43.9 1.0 NZ C:LYS212 3.8 58.6 1.0 CG B:GLU314 4.1 45.5 1.0 CB B:ARG310 4.1 49.0 1.0 CD B:GLU314 4.1 64.8 1.0 CG B:ARG310 4.2 50.9 1.0 CB B:VAL353 4.2 58.0 1.0 CA B:VAL353 4.3 60.7 1.0 CD B:ARG310 4.3 37.5 1.0 CE C:LYS212 4.4 64.4 1.0 O B:ARG310 4.7 57.0 1.0 CD C:LYS212 4.8 66.6 1.0 CA B:ARG310 4.8 50.0 1.0 CD2 B:LEU352 4.8 38.4 1.0 CG B:LEU352 4.9 38.4 1.0 O B:LEU352 4.9 53.9 1.0 N B:VAL353 4.9 37.5 1.0

Chlorine binding site 3 out of 3 in the Crystal Structure of Acid-Sensing Ion Channel in Complex with Psalmotoxin 1 at Low pH


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of Acid-Sensing Ion Channel in Complex with Psalmotoxin 1 at Low pH within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl501 b:77.2 occ:1.00 NE C:ARG310 3.0 44.4 1.0 OE2 C:GLU314 3.4 68.0 1.0 NH1 C:ARG310 3.4 47.6 1.0 CG1 C:VAL353 3.6 60.8 1.0 CZ C:ARG310 3.6 48.1 1.0 NZ A:LYS212 3.9 64.5 1.0 CB C:ARG310 4.0 48.6 1.0 CG C:ARG310 4.0 48.2 1.0 CD C:ARG310 4.0 42.6 1.0 CG C:GLU314 4.2 48.9 1.0 CD C:GLU314 4.3 69.8 1.0 CB C:VAL353 4.4 58.7 1.0 CA C:VAL353 4.5 55.2 1.0 CE A:LYS212 4.5 66.8 1.0 CA C:ARG310 4.6 50.0 1.0 O C:ARG310 4.7 56.9 1.0 CD A:LYS212 4.8 64.9 1.0 NH2 C:ARG310 4.9 46.8 1.0 CB C:CYS360 5.0 64.1 1.0

I.Baconguis, E.Gouaux. Structural Plasticity and Dynamic Selectivity of Acid-Sensing Ion Channel-Spider Toxin Complexes. Nature V. 489 400 2012.
ISSN: ISSN 0028-0836
PubMed: 22842900
DOI: 10.1038/NATURE11375