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Chlorine in PDB 4g49: Room Temperature X-Ray Diffraction of Cisplatin Binding to Hewl in Aqueous Media After 15 Months of Crystal Storage

Enzymatic activity of Room Temperature X-Ray Diffraction of Cisplatin Binding to Hewl in Aqueous Media After 15 Months of Crystal Storage

All present enzymatic activity of Room Temperature X-Ray Diffraction of Cisplatin Binding to Hewl in Aqueous Media After 15 Months of Crystal Storage:
3.2.1.17;

Protein crystallography data

The structure of Room Temperature X-Ray Diffraction of Cisplatin Binding to Hewl in Aqueous Media After 15 Months of Crystal Storage, PDB code: 4g49 was solved by S.W.M.Tanley, A.M.M.Schreurs, L.M.J.Kroon-Batenburg, J.R.Helliwell, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 55.63 / 2.40
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 78.671, 78.671, 38.068, 90.00, 90.00, 90.00
R / Rfree (%) 17.6 / 21

Other elements in 4g49:

The structure of Room Temperature X-Ray Diffraction of Cisplatin Binding to Hewl in Aqueous Media After 15 Months of Crystal Storage also contains other interesting chemical elements:

Platinum (Pt) 2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Room Temperature X-Ray Diffraction of Cisplatin Binding to Hewl in Aqueous Media After 15 Months of Crystal Storage (pdb code 4g49). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Room Temperature X-Ray Diffraction of Cisplatin Binding to Hewl in Aqueous Media After 15 Months of Crystal Storage, PDB code: 4g49:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in 4g49

Go back to Chlorine Binding Sites List in 4g49
Chlorine binding site 1 out of 2 in the Room Temperature X-Ray Diffraction of Cisplatin Binding to Hewl in Aqueous Media After 15 Months of Crystal Storage


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Room Temperature X-Ray Diffraction of Cisplatin Binding to Hewl in Aqueous Media After 15 Months of Crystal Storage within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl201

b:51.5
occ:1.00
OH A:TYR23 2.9 31.3 1.0
CZ A:TYR23 3.5 31.5 1.0
CE2 A:TYR23 3.6 30.7 1.0
CA A:GLY104 4.3 32.4 1.0
O A:ARG21 4.5 38.1 1.0
CE1 A:TYR23 4.7 31.6 1.0
CD2 A:TYR23 4.9 30.2 1.0
N A:GLY104 4.9 33.5 1.0

Chlorine binding site 2 out of 2 in 4g49

Go back to Chlorine Binding Sites List in 4g49
Chlorine binding site 2 out of 2 in the Room Temperature X-Ray Diffraction of Cisplatin Binding to Hewl in Aqueous Media After 15 Months of Crystal Storage


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Room Temperature X-Ray Diffraction of Cisplatin Binding to Hewl in Aqueous Media After 15 Months of Crystal Storage within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl202

b:59.7
occ:1.00
N A:GLY26 2.9 31.9 1.0
O A:HOH324 3.0 48.9 1.0
OG A:SER24 3.1 34.8 1.0
CB A:SER24 3.3 33.4 1.0
CA A:GLY26 3.3 30.3 1.0
N A:LEU25 3.9 33.8 1.0
CA A:GLN121 3.9 49.0 1.0
C A:SER24 4.1 33.4 1.0
C A:LEU25 4.1 32.7 1.0
N A:GLN121 4.2 47.9 1.0
CG1 A:ILE124 4.2 42.6 1.0
CA A:SER24 4.3 34.3 1.0
O A:VAL120 4.4 46.4 1.0
CA A:LEU25 4.4 33.8 1.0
CD1 A:ILE124 4.4 43.4 1.0
C A:VAL120 4.5 46.8 1.0
C A:GLY26 4.5 30.7 1.0
CB A:GLN121 4.5 56.5 1.0
O A:SER24 4.6 30.0 1.0
CG2 A:VAL120 4.6 38.6 1.0
CD A:GLN121 4.6 72.7 1.0
OE1 A:GLN121 4.6 74.2 1.0
N A:ASN27 4.7 29.1 1.0
CB A:LEU25 4.7 34.6 1.0
NE2 A:GLN121 4.8 77.8 1.0
CG2 A:ILE124 5.0 40.2 1.0
CG A:GLN121 5.0 65.3 1.0

Reference:

S.W.Tanley, A.M.Schreurs, L.M.Kroon-Batenburg, J.R.Helliwell. Room-Temperature X-Ray Diffraction Studies of Cisplatin and Carboplatin Binding to HIS15 of Hewl After Prolonged Chemical Exposure. Acta Crystallogr.,Sect.F V. 68 1300 2012.
ISSN: ESSN 1744-3091
PubMed: 23143236
DOI: 10.1107/S1744309112042005
Page generated: Wed Oct 28 11:44:21 2020

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