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Chlorine in PDB 4g4b: Room Temperature X-Ray Diffraction Study of Cisplatin Binding to Hewl in Dmso Media with Nag After 7 Months of Crystal Storage

Enzymatic activity of Room Temperature X-Ray Diffraction Study of Cisplatin Binding to Hewl in Dmso Media with Nag After 7 Months of Crystal Storage

All present enzymatic activity of Room Temperature X-Ray Diffraction Study of Cisplatin Binding to Hewl in Dmso Media with Nag After 7 Months of Crystal Storage:
3.2.1.17;

Protein crystallography data

The structure of Room Temperature X-Ray Diffraction Study of Cisplatin Binding to Hewl in Dmso Media with Nag After 7 Months of Crystal Storage, PDB code: 4g4b was solved by S.W.M.Tanley, A.M.M.Schreurs, L.M.J.Kroon-Batenburg, J.R.Helliwell, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 55.74 / 2.10
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 78.822, 78.822, 38.019, 90.00, 90.00, 90.00
R / Rfree (%) 15.9 / 22.7

Other elements in 4g4b:

The structure of Room Temperature X-Ray Diffraction Study of Cisplatin Binding to Hewl in Dmso Media with Nag After 7 Months of Crystal Storage also contains other interesting chemical elements:

Platinum (Pt) 2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Room Temperature X-Ray Diffraction Study of Cisplatin Binding to Hewl in Dmso Media with Nag After 7 Months of Crystal Storage (pdb code 4g4b). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Room Temperature X-Ray Diffraction Study of Cisplatin Binding to Hewl in Dmso Media with Nag After 7 Months of Crystal Storage, PDB code: 4g4b:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in 4g4b

Go back to Chlorine Binding Sites List in 4g4b
Chlorine binding site 1 out of 4 in the Room Temperature X-Ray Diffraction Study of Cisplatin Binding to Hewl in Dmso Media with Nag After 7 Months of Crystal Storage


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Room Temperature X-Ray Diffraction Study of Cisplatin Binding to Hewl in Dmso Media with Nag After 7 Months of Crystal Storage within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl203

b:59.3
occ:1.00
 CL2 A:CPT203 0.0 59.3 1.0
PT1 A:CPT203 2.4 43.8 0.8
N2 A:CPT203 3.5 24.4 1.0
CL1 A:CPT203 4.0 58.2 1.0
NZ A:LYS96 4.4 27.5 1.0
O A:HIS15 4.5 29.8 1.0
ND1 A:HIS15 4.8 37.9 1.0
OD1 A:ASN93 5.0 49.9 1.0

Chlorine binding site 2 out of 4 in 4g4b

Go back to Chlorine Binding Sites List in 4g4b
Chlorine binding site 2 out of 4 in the Room Temperature X-Ray Diffraction Study of Cisplatin Binding to Hewl in Dmso Media with Nag After 7 Months of Crystal Storage


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Room Temperature X-Ray Diffraction Study of Cisplatin Binding to Hewl in Dmso Media with Nag After 7 Months of Crystal Storage within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl203

b:58.2
occ:1.00
 CL1 A:CPT203 0.0 58.2 1.0
PT1 A:CPT203 2.5 43.8 0.8
ND1 A:HIS15 3.0 37.9 1.0
CE1 A:HIS15 3.3 38.2 1.0
O A:ARG14 3.7 29.5 1.0
CG A:HIS15 3.7 32.1 1.0
NH2 A:ARG14 3.8 52.7 1.0
CZ A:ARG14 3.9 48.2 1.0
CA A:HIS15 3.9 30.1 1.0
NE A:ARG14 4.0 46.3 1.0
CL2 A:CPT203 4.0 59.3 1.0
NE2 A:HIS15 4.1 35.6 1.0
C A:ARG14 4.2 29.4 1.0
CB A:HIS15 4.3 28.7 1.0
CD2 A:HIS15 4.3 34.3 1.0
N A:HIS15 4.3 30.6 1.0
CG A:ARG14 4.4 35.7 1.0
N2 A:CPT203 4.5 24.4 1.0
NH1 A:ARG14 4.6 50.2 1.0
CD A:ARG14 4.7 40.4 1.0

Chlorine binding site 3 out of 4 in 4g4b

Go back to Chlorine Binding Sites List in 4g4b
Chlorine binding site 3 out of 4 in the Room Temperature X-Ray Diffraction Study of Cisplatin Binding to Hewl in Dmso Media with Nag After 7 Months of Crystal Storage


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Room Temperature X-Ray Diffraction Study of Cisplatin Binding to Hewl in Dmso Media with Nag After 7 Months of Crystal Storage within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl206

b:36.7
occ:1.00
 OH A:TYR23 2.7 18.0 1.0
CZ A:TYR23 3.4 18.8 1.0
CE2 A:TYR23 3.5 19.2 1.0
CA A:GLY104 4.2 23.0 1.0
O A:HOH319 4.3 35.1 1.0
O A:ARG21 4.6 23.3 1.0
CE1 A:TYR23 4.6 19.0 1.0
CD2 A:TYR23 4.7 18.6 1.0
N A:GLY104 4.9 24.4 1.0

Chlorine binding site 4 out of 4 in 4g4b

Go back to Chlorine Binding Sites List in 4g4b
Chlorine binding site 4 out of 4 in the Room Temperature X-Ray Diffraction Study of Cisplatin Binding to Hewl in Dmso Media with Nag After 7 Months of Crystal Storage


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Room Temperature X-Ray Diffraction Study of Cisplatin Binding to Hewl in Dmso Media with Nag After 7 Months of Crystal Storage within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl207

b:63.4
occ:1.00
 NZ A:LYS96 2.7 27.5 1.0
CE A:LYS96 3.1 25.4 1.0
CD A:LYS96 3.6 23.8 1.0
CE1 A:TYR20 4.4 29.6 1.0
O A:HIS15 4.9 29.8 1.0
CG A:LYS96 5.0 21.9 1.0

Reference:

S.W.Tanley, A.M.Schreurs, L.M.Kroon-Batenburg, J.R.Helliwell. Room-Temperature X-Ray Diffraction Studies of Cisplatin and Carboplatin Binding to HIS15 of Hewl After Prolonged Chemical Exposure. Acta Crystallogr.,Sect.F V. 68 1300 2012.
ISSN: ESSN 1744-3091
PubMed: 23143236
DOI: 10.1107/S1744309112042005
Page generated: Wed Oct 28 11:44:21 2020

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