Atomistry » Chlorine » PDB 4fv2-4g7v » 4g4b
Atomistry »
  Chlorine »
    PDB 4fv2-4g7v »
      4g4b »

Chlorine in PDB 4g4b: Room Temperature X-Ray Diffraction Study of Cisplatin Binding to Hewl in Dmso Media with Nag After 7 Months of Crystal Storage

Enzymatic activity of Room Temperature X-Ray Diffraction Study of Cisplatin Binding to Hewl in Dmso Media with Nag After 7 Months of Crystal Storage

All present enzymatic activity of Room Temperature X-Ray Diffraction Study of Cisplatin Binding to Hewl in Dmso Media with Nag After 7 Months of Crystal Storage:
3.2.1.17;

Protein crystallography data

The structure of Room Temperature X-Ray Diffraction Study of Cisplatin Binding to Hewl in Dmso Media with Nag After 7 Months of Crystal Storage, PDB code: 4g4b was solved by S.W.M.Tanley, A.M.M.Schreurs, L.M.J.Kroon-Batenburg, J.R.Helliwell, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 55.74 / 2.10
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 78.822, 78.822, 38.019, 90.00, 90.00, 90.00
R / Rfree (%) 15.9 / 22.7

Other elements in 4g4b:

The structure of Room Temperature X-Ray Diffraction Study of Cisplatin Binding to Hewl in Dmso Media with Nag After 7 Months of Crystal Storage also contains other interesting chemical elements:

Platinum (Pt) 2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Room Temperature X-Ray Diffraction Study of Cisplatin Binding to Hewl in Dmso Media with Nag After 7 Months of Crystal Storage (pdb code 4g4b). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Room Temperature X-Ray Diffraction Study of Cisplatin Binding to Hewl in Dmso Media with Nag After 7 Months of Crystal Storage, PDB code: 4g4b:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in 4g4b

Go back to Chlorine Binding Sites List in 4g4b
Chlorine binding site 1 out of 4 in the Room Temperature X-Ray Diffraction Study of Cisplatin Binding to Hewl in Dmso Media with Nag After 7 Months of Crystal Storage


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Room Temperature X-Ray Diffraction Study of Cisplatin Binding to Hewl in Dmso Media with Nag After 7 Months of Crystal Storage within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl203

b:59.3
occ:1.00
 CL2 A:CPT203 0.0 59.3 1.0
PT1 A:CPT203 2.4 43.8 0.8
N2 A:CPT203 3.5 24.4 1.0
CL1 A:CPT203 4.0 58.2 1.0
NZ A:LYS96 4.4 27.5 1.0
O A:HIS15 4.5 29.8 1.0
ND1 A:HIS15 4.8 37.9 1.0
OD1 A:ASN93 5.0 49.9 1.0

Chlorine binding site 2 out of 4 in 4g4b

Go back to Chlorine Binding Sites List in 4g4b
Chlorine binding site 2 out of 4 in the Room Temperature X-Ray Diffraction Study of Cisplatin Binding to Hewl in Dmso Media with Nag After 7 Months of Crystal Storage


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Room Temperature X-Ray Diffraction Study of Cisplatin Binding to Hewl in Dmso Media with Nag After 7 Months of Crystal Storage within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl203

b:58.2
occ:1.00
 CL1 A:CPT203 0.0 58.2 1.0
PT1 A:CPT203 2.5 43.8 0.8
ND1 A:HIS15 3.0 37.9 1.0
CE1 A:HIS15 3.3 38.2 1.0
O A:ARG14 3.7 29.5 1.0
CG A:HIS15 3.7 32.1 1.0
NH2 A:ARG14 3.8 52.7 1.0
CZ A:ARG14 3.9 48.2 1.0
CA A:HIS15 3.9 30.1 1.0
NE A:ARG14 4.0 46.3 1.0
CL2 A:CPT203 4.0 59.3 1.0
NE2 A:HIS15 4.1 35.6 1.0
C A:ARG14 4.2 29.4 1.0
CB A:HIS15 4.3 28.7 1.0
CD2 A:HIS15 4.3 34.3 1.0
N A:HIS15 4.3 30.6 1.0
CG A:ARG14 4.4 35.7 1.0
N2 A:CPT203 4.5 24.4 1.0
NH1 A:ARG14 4.6 50.2 1.0
CD A:ARG14 4.7 40.4 1.0

Chlorine binding site 3 out of 4 in 4g4b

Go back to Chlorine Binding Sites List in 4g4b
Chlorine binding site 3 out of 4 in the Room Temperature X-Ray Diffraction Study of Cisplatin Binding to Hewl in Dmso Media with Nag After 7 Months of Crystal Storage


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Room Temperature X-Ray Diffraction Study of Cisplatin Binding to Hewl in Dmso Media with Nag After 7 Months of Crystal Storage within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl206

b:36.7
occ:1.00
 OH A:TYR23 2.7 18.0 1.0
CZ A:TYR23 3.4 18.8 1.0
CE2 A:TYR23 3.5 19.2 1.0
CA A:GLY104 4.2 23.0 1.0
O A:HOH319 4.3 35.1 1.0
O A:ARG21 4.6 23.3 1.0
CE1 A:TYR23 4.6 19.0 1.0
CD2 A:TYR23 4.7 18.6 1.0
N A:GLY104 4.9 24.4 1.0

Chlorine binding site 4 out of 4 in 4g4b

Go back to Chlorine Binding Sites List in 4g4b
Chlorine binding site 4 out of 4 in the Room Temperature X-Ray Diffraction Study of Cisplatin Binding to Hewl in Dmso Media with Nag After 7 Months of Crystal Storage


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Room Temperature X-Ray Diffraction Study of Cisplatin Binding to Hewl in Dmso Media with Nag After 7 Months of Crystal Storage within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl207

b:63.4
occ:1.00
 NZ A:LYS96 2.7 27.5 1.0
CE A:LYS96 3.1 25.4 1.0
CD A:LYS96 3.6 23.8 1.0
CE1 A:TYR20 4.4 29.6 1.0
O A:HIS15 4.9 29.8 1.0
CG A:LYS96 5.0 21.9 1.0

Reference:

S.W.Tanley, A.M.Schreurs, L.M.Kroon-Batenburg, J.R.Helliwell. Room-Temperature X-Ray Diffraction Studies of Cisplatin and Carboplatin Binding to HIS15 of Hewl After Prolonged Chemical Exposure. Acta Crystallogr.,Sect.F V. 68 1300 2012.
ISSN: ESSN 1744-3091
PubMed: 23143236
DOI: 10.1107/S1744309112042005
Page generated: Sun Jul 21 14:17:20 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy