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Chlorine in PDB 4gce: Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 3

Enzymatic activity of Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 3

All present enzymatic activity of Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 3:
3.2.1.17;

Protein crystallography data

The structure of Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 3, PDB code: 4gce was solved by J.R.Helliwell, S.W.M.Tanley, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 56.47 / 2.90
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 79.863, 79.863, 37.802, 90.00, 90.00, 90.00
R / Rfree (%) 17.4 / 23.4

Other elements in 4gce:

The structure of Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 3 also contains other interesting chemical elements:

Platinum (Pt) 2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 3 (pdb code 4gce). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 3, PDB code: 4gce:

Chlorine binding site 1 out of 1 in 4gce

Go back to Chlorine Binding Sites List in 4gce
Chlorine binding site 1 out of 1 in the Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 3


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 3 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl202

b:51.3
occ:0.60
CL2 A:CPT202 0.0 51.3 0.6
PT1 A:CPT202 2.4 61.5 0.6
OD1 A:ASN93 2.6 32.9 1.0
ND1 A:HIS15 3.6 42.1 1.0
CG A:ASN93 3.7 31.2 1.0
O A:HIS15 3.8 38.5 1.0
CG2 A:THR89 4.1 30.2 1.0
CG1 A:VAL92 4.1 22.8 1.0
ND2 A:ASN93 4.2 33.6 1.0
CB A:HIS15 4.3 37.6 1.0
CG A:HIS15 4.3 39.2 1.0
NZ A:LYS96 4.4 29.5 1.0
N1 A:CPT202 4.5 52.6 0.6
O A:THR89 4.5 26.8 1.0
CE1 A:HIS15 4.6 43.5 1.0
CA A:HIS15 4.6 38.9 1.0
C A:HIS15 4.6 38.5 1.0
N A:ASN93 4.8 23.9 1.0
CE A:LYS96 4.8 27.8 1.0
CB A:VAL92 4.8 21.9 1.0
CB A:ASN93 5.0 28.6 1.0

Reference:

J.R.Helliwell, S.W.Tanley. The Crystal Structure Analysis of the Relative Binding of Cisplatin and Carboplatin in A Mixture with Histidine in A Protein Studied at 100 and 300 K with Repeated X-Ray Irradiation. Acta Crystallogr.,Sect.D V. 69 121 2013.
ISSN: ISSN 0907-4449
PubMed: 23275170
DOI: 10.1107/S090744491204423X
Page generated: Wed Oct 28 11:44:46 2020

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