Chlorine in PDB 4gce: Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 3

Enzymatic activity of Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 3

All present enzymatic activity of Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 3:
3.2.1.17;

Protein crystallography data

The structure of Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 3, PDB code: 4gce was solved by J.R.Helliwell, S.W.M.Tanley, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	56.47 / 2.90
*Space group*	P 4₃ 2₁ 2
*Cell size a, b, c (Å), α, β, γ (°)*	79.863, 79.863, 37.802, 90.00, 90.00, 90.00
*R / R_free (%)*	17.4 / 23.4

Other elements in 4gce:

The structure of Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 3 also contains other interesting chemical elements:

Platinum

(Pt)

2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 3 (pdb code 4gce). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 3, PDB code: 4gce:

Chlorine binding site 1 out of 1 in 4gce

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Chlorine Binding Sites List in 4gce

Chlorine binding site 1 out of 1 in the Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 3

Mono view

Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 3 within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Cl202 b:51.3 occ:0.60	CL2	A:CPT202	0.0	51.3	0.6
	PT1	A:CPT202	2.4	61.5	0.6
	OD1	A:ASN93	2.6	32.9	1.0
	ND1	A:HIS15	3.6	42.1	1.0
	CG	A:ASN93	3.7	31.2	1.0
	O	A:HIS15	3.8	38.5	1.0
	CG2	A:THR89	4.1	30.2	1.0
	CG1	A:VAL92	4.1	22.8	1.0
	ND2	A:ASN93	4.2	33.6	1.0
	CB	A:HIS15	4.3	37.6	1.0
	CG	A:HIS15	4.3	39.2	1.0
	NZ	A:LYS96	4.4	29.5	1.0
	N1	A:CPT202	4.5	52.6	0.6
	O	A:THR89	4.5	26.8	1.0
	CE1	A:HIS15	4.6	43.5	1.0
	CA	A:HIS15	4.6	38.9	1.0
	C	A:HIS15	4.6	38.5	1.0
	N	A:ASN93	4.8	23.9	1.0
	CE	A:LYS96	4.8	27.8	1.0
	CB	A:VAL92	4.8	21.9	1.0
	CB	A:ASN93	5.0	28.6	1.0

Reference:

J.R.Helliwell, S.W.Tanley. The Crystal Structure Analysis of the Relative Binding of Cisplatin and Carboplatin in A Mixture with Histidine in A Protein Studied at 100 and 300 K with Repeated X-Ray Irradiation. Acta Crystallogr.,Sect.D V. 69 121 2013.
ISSN: ISSN 0907-4449
PubMed: 23275170
DOI: 10.1107/S090744491204423X

Page generated: Sat Dec 12 10:39:09 2020

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