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Atomistry » Chlorine » PDB 4gen-4glo » 4gfm | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 4gen-4glo » 4gfm » |
Chlorine in PDB 4gfm: JAK2 Kinase (JH1 Domain) with 2,6-Dichloro-N-(2-Oxo-2,5- Dihydropyridin-4-Yl)BenzamideEnzymatic activity of JAK2 Kinase (JH1 Domain) with 2,6-Dichloro-N-(2-Oxo-2,5- Dihydropyridin-4-Yl)Benzamide
All present enzymatic activity of JAK2 Kinase (JH1 Domain) with 2,6-Dichloro-N-(2-Oxo-2,5- Dihydropyridin-4-Yl)Benzamide:
2.7.10.2; Protein crystallography data
The structure of JAK2 Kinase (JH1 Domain) with 2,6-Dichloro-N-(2-Oxo-2,5- Dihydropyridin-4-Yl)Benzamide, PDB code: 4gfm
was solved by
C.Eigenbrot,
M.Ultsch,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the JAK2 Kinase (JH1 Domain) with 2,6-Dichloro-N-(2-Oxo-2,5- Dihydropyridin-4-Yl)Benzamide
(pdb code 4gfm). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the JAK2 Kinase (JH1 Domain) with 2,6-Dichloro-N-(2-Oxo-2,5- Dihydropyridin-4-Yl)Benzamide, PDB code: 4gfm: Jump to Chlorine binding site number: 1; 2; Chlorine binding site 1 out of 2 in 4gfmGo back to Chlorine Binding Sites List in 4gfm
Chlorine binding site 1 out
of 2 in the JAK2 Kinase (JH1 Domain) with 2,6-Dichloro-N-(2-Oxo-2,5- Dihydropyridin-4-Yl)Benzamide
Mono view Stereo pair view
Chlorine binding site 2 out of 2 in 4gfmGo back to Chlorine Binding Sites List in 4gfm
Chlorine binding site 2 out
of 2 in the JAK2 Kinase (JH1 Domain) with 2,6-Dichloro-N-(2-Oxo-2,5- Dihydropyridin-4-Yl)Benzamide
Mono view Stereo pair view
Reference:
J.Liang,
V.Tsui,
A.Van Abbema,
L.Bao,
K.Barrett,
M.Beresini,
L.Berezhkovskiy,
W.S.Blair,
C.Chang,
J.Driscoll,
C.Eigenbrot,
N.Ghilardi,
P.Gibbons,
J.Halladay,
A.Johnson,
P.B.Kohli,
Y.Lai,
M.Liimatta,
P.Mantik,
K.Menghrajani,
J.Murray,
A.Sambrone,
Y.Xiao,
S.Shia,
Y.Shin,
J.Smith,
S.Sohn,
M.Stanley,
M.Ultsch,
B.Zhang,
L.C.Wu,
S.Magnuson.
Lead Identification of Novel and Selective TYK2 Inhibitors. Eur.J.Med.Chem. V. 67 175 2013.
Page generated: Sat Dec 12 10:39:26 2020
ISSN: ISSN 0223-5234 PubMed: 23867602 DOI: 10.1016/J.EJMECH.2013.03.070 |
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