Chlorine in PDB 4ghl: Structural Basis For Marburg Virus VP35 Mediate Immune Evasion Mechanisms

The structure of Structural Basis For Marburg Virus VP35 Mediate Immune Evasion Mechanisms, PDB code: 4ghl was solved by P.Ramanan, D.M.Borek, Z.Otwinowski, D.W.Leung, G.K.Amarasinghe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	37.87 / 2.02
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	83.771, 93.384, 102.071, 90.00, 90.00, 90.00
R / Rfree (%)	18.7 / 24

The structure of Structural Basis For Marburg Virus VP35 Mediate Immune Evasion Mechanisms also contains other interesting chemical elements:

Magnesium

(Mg)

11 atoms

The binding sites of Chlorine atom in the Structural Basis For Marburg Virus VP35 Mediate Immune Evasion Mechanisms (pdb code 4ghl). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Structural Basis For Marburg Virus VP35 Mediate Immune Evasion Mechanisms, PDB code: 4ghl:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in the Structural Basis For Marburg Virus VP35 Mediate Immune Evasion Mechanisms


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structural Basis For Marburg Virus VP35 Mediate Immune Evasion Mechanisms within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl402 b:70.3 occ:1.00 CE1 B:TYR240 3.9 52.1 1.0 NZ C:LYS241 3.9 74.6 1.0 OH B:TYR240 4.4 66.1 1.0 NZ B:LYS241 4.4 54.7 1.0 CE C:LYS241 4.5 64.9 1.0 CZ B:TYR240 4.6 51.2 1.0 O B:HOH547 4.6 37.8 1.0 CD1 B:TYR240 4.8 43.5 1.0

Chlorine binding site 2 out of 4 in the Structural Basis For Marburg Virus VP35 Mediate Immune Evasion Mechanisms


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Structural Basis For Marburg Virus VP35 Mediate Immune Evasion Mechanisms within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl403 b:60.3 occ:1.00 CB B:GLN233 3.8 19.1 1.0 OE1 B:GLN233 3.9 37.9 1.0 O B:HOH509 4.1 25.0 1.0 CD B:GLN233 4.2 32.8 1.0 CG2 B:VAL234 4.4 19.1 1.0 CG2 B:ILE230 4.4 16.7 1.0 O B:ILE230 4.5 21.0 1.0 CG B:GLN233 4.6 24.7 1.0 NE2 B:GLN233 4.6 43.1 1.0 CD1 B:ILE284 4.7 25.4 1.0 N B:VAL234 4.8 15.7 1.0 C B:GLN233 4.9 15.7 1.0

Chlorine binding site 3 out of 4 in the Structural Basis For Marburg Virus VP35 Mediate Immune Evasion Mechanisms


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Structural Basis For Marburg Virus VP35 Mediate Immune Evasion Mechanisms within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl404 b:78.7 occ:1.00 NZ B:LYS241 3.0 54.7 1.0 CE B:LYS241 3.6 61.7 1.0 CE B:LYS237 4.1 30.1 1.0 NZ B:LYS237 4.1 37.8 1.0

Chlorine binding site 4 out of 4 in the Structural Basis For Marburg Virus VP35 Mediate Immune Evasion Mechanisms


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Structural Basis For Marburg Virus VP35 Mediate Immune Evasion Mechanisms within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl403 b:57.1 occ:1.00 N C:ARG285 3.3 19.4 1.0 O C:HOH531 3.3 27.4 1.0 CB C:ARG285 3.6 18.5 1.0 CG C:ARG285 3.9 17.3 1.0 CA C:ILE284 4.1 17.4 1.0 CA C:ARG285 4.1 20.2 1.0 C C:ILE284 4.2 18.8 1.0 O C:HOH555 4.3 33.4 1.0 O C:VAL283 4.3 20.6 1.0 NH1 C:ARG285 4.4 17.2 1.0 CD C:ARG285 4.5 17.5 1.0 O C:ARG285 4.7 16.9 1.0 CG2 C:ILE284 4.7 21.7 1.0 C C:ARG285 4.9 18.9 1.0 CB C:ILE284 5.0 22.4 1.0 N C:ILE284 5.0 20.6 1.0

P.Ramanan, M.R.Edwards, R.S.Shabman, D.W.Leung, A.C.Endlich-Frazier, D.M.Borek, Z.Otwinowski, G.Liu, J.Huh, C.F.Basler, G.K.Amarasinghe. Structural Basis For Marburg Virus VP35-Mediated Immune Evasion Mechanisms. Proc.Natl.Acad.Sci.Usa V. 109 20661 2012.
ISSN: ISSN 0027-8424
PubMed: 23185024
DOI: 10.1073/PNAS.1213559109