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Atomistry » Chlorine » PDB 4gen-4glo » 4gih | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 4gen-4glo » 4gih » |
Chlorine in PDB 4gih: TYK2 (JH1) in Complex with 2,6-Dichloro-N-{2-[(Cyclopropylcarbonyl) Amino]Pyridin-4-Yl}BenzamideEnzymatic activity of TYK2 (JH1) in Complex with 2,6-Dichloro-N-{2-[(Cyclopropylcarbonyl) Amino]Pyridin-4-Yl}Benzamide
All present enzymatic activity of TYK2 (JH1) in Complex with 2,6-Dichloro-N-{2-[(Cyclopropylcarbonyl) Amino]Pyridin-4-Yl}Benzamide:
2.7.10.2; Protein crystallography data
The structure of TYK2 (JH1) in Complex with 2,6-Dichloro-N-{2-[(Cyclopropylcarbonyl) Amino]Pyridin-4-Yl}Benzamide, PDB code: 4gih
was solved by
M.H.Ultsch,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the TYK2 (JH1) in Complex with 2,6-Dichloro-N-{2-[(Cyclopropylcarbonyl) Amino]Pyridin-4-Yl}Benzamide
(pdb code 4gih). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the TYK2 (JH1) in Complex with 2,6-Dichloro-N-{2-[(Cyclopropylcarbonyl) Amino]Pyridin-4-Yl}Benzamide, PDB code: 4gih: Jump to Chlorine binding site number: 1; 2; Chlorine binding site 1 out of 2 in 4gihGo back to Chlorine Binding Sites List in 4gih
Chlorine binding site 1 out
of 2 in the TYK2 (JH1) in Complex with 2,6-Dichloro-N-{2-[(Cyclopropylcarbonyl) Amino]Pyridin-4-Yl}Benzamide
Mono view Stereo pair view
Chlorine binding site 2 out of 2 in 4gihGo back to Chlorine Binding Sites List in 4gih
Chlorine binding site 2 out
of 2 in the TYK2 (JH1) in Complex with 2,6-Dichloro-N-{2-[(Cyclopropylcarbonyl) Amino]Pyridin-4-Yl}Benzamide
Mono view Stereo pair view
Reference:
J.Liang,
V.Tsui,
A.Van Abbema,
L.Bao,
K.Barrett,
M.Beresini,
L.Berezhkovskiy,
W.S.Blair,
C.Chang,
J.Driscoll,
C.Eigenbrot,
N.Ghilardi,
P.Gibbons,
J.Halladay,
A.Johnson,
P.B.Kohli,
Y.Lai,
M.Liimatta,
P.Mantik,
K.Menghrajani,
J.Murray,
A.Sambrone,
Y.Xiao,
S.Shia,
Y.Shin,
J.Smith,
S.Sohn,
M.Stanley,
M.Ultsch,
B.Zhang,
L.C.Wu,
S.Magnuson.
Lead Identification of Novel and Selective TYK2 Inhibitors. Eur.J.Med.Chem. V. 67 175 2013.
Page generated: Sat Dec 12 10:39:44 2020
ISSN: ISSN 0223-5234 PubMed: 23867602 DOI: 10.1016/J.EJMECH.2013.03.070 |
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