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Chlorine in PDB 4gk8: Crystal Structure of Histidinol Phosphate Phosphatase (Hisk) From Lactococcus Lactis Subsp. Lactis IL1403 Complexed with Zn and L- Histidinol Arsenate

Enzymatic activity of Crystal Structure of Histidinol Phosphate Phosphatase (Hisk) From Lactococcus Lactis Subsp. Lactis IL1403 Complexed with Zn and L- Histidinol Arsenate

All present enzymatic activity of Crystal Structure of Histidinol Phosphate Phosphatase (Hisk) From Lactococcus Lactis Subsp. Lactis IL1403 Complexed with Zn and L- Histidinol Arsenate:
3.1.3.15;

Protein crystallography data

The structure of Crystal Structure of Histidinol Phosphate Phosphatase (Hisk) From Lactococcus Lactis Subsp. Lactis IL1403 Complexed with Zn and L- Histidinol Arsenate, PDB code: 4gk8 was solved by A.A.Fedorov, E.V.Fedorov, S.Ghodge, F.M.Raushel, S.C.Almo, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 43.31 / 1.93
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 85.860, 86.622, 45.093, 90.00, 90.00, 90.00
R / Rfree (%) 16.2 / 19.6

Other elements in 4gk8:

The structure of Crystal Structure of Histidinol Phosphate Phosphatase (Hisk) From Lactococcus Lactis Subsp. Lactis IL1403 Complexed with Zn and L- Histidinol Arsenate also contains other interesting chemical elements:

Arsenic (As) 1 atom
Zinc (Zn) 4 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Histidinol Phosphate Phosphatase (Hisk) From Lactococcus Lactis Subsp. Lactis IL1403 Complexed with Zn and L- Histidinol Arsenate (pdb code 4gk8). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Crystal Structure of Histidinol Phosphate Phosphatase (Hisk) From Lactococcus Lactis Subsp. Lactis IL1403 Complexed with Zn and L- Histidinol Arsenate, PDB code: 4gk8:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in 4gk8

Go back to Chlorine Binding Sites List in 4gk8
Chlorine binding site 1 out of 3 in the Crystal Structure of Histidinol Phosphate Phosphatase (Hisk) From Lactococcus Lactis Subsp. Lactis IL1403 Complexed with Zn and L- Histidinol Arsenate


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Histidinol Phosphate Phosphatase (Hisk) From Lactococcus Lactis Subsp. Lactis IL1403 Complexed with Zn and L- Histidinol Arsenate within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl306

b:24.2
occ:1.00
 ZN A:ZN304 2.2 21.4 1.0
O A:HOH409 3.2 18.6 1.0
N3 A:IMD309 3.4 21.6 1.0
NE2 A:HIS32 3.5 20.7 1.0
NE2 A:HIS240 3.5 22.4 1.0
CD2 A:HIS240 3.7 21.0 1.0
CD2 A:HIS32 3.7 16.2 1.0
CG2 A:ILE239 3.7 20.3 1.0
CD A:ARG243 3.9 21.6 1.0
CD2 A:LEU34 4.0 16.7 1.0
C2 A:IMD309 4.0 23.7 1.0
NE A:ARG243 4.1 20.2 1.0
C4 A:IMD309 4.3 21.8 1.0
CE3 A:TRP236 4.4 20.7 1.0
CZ3 A:TRP236 4.4 19.8 1.0
CZ A:ARG243 4.5 26.9 1.0
CG A:LYS5 4.6 20.9 1.0
NH1 A:ARG243 4.6 23.8 1.0
CB A:LYS5 4.7 18.5 1.0
CE1 A:HIS32 4.8 18.6 1.0
CE1 A:HIS240 4.8 19.2 1.0
CB A:ILE239 4.9 21.8 1.0
CG A:HIS240 5.0 20.0 1.0

Chlorine binding site 2 out of 3 in 4gk8

Go back to Chlorine Binding Sites List in 4gk8
Chlorine binding site 2 out of 3 in the Crystal Structure of Histidinol Phosphate Phosphatase (Hisk) From Lactococcus Lactis Subsp. Lactis IL1403 Complexed with Zn and L- Histidinol Arsenate


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Histidinol Phosphate Phosphatase (Hisk) From Lactococcus Lactis Subsp. Lactis IL1403 Complexed with Zn and L- Histidinol Arsenate within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl307

b:28.5
occ:1.00
 N A:TYR46 3.2 20.7 1.0
NH1 A:ARG43 3.3 20.6 1.0
NH2 A:ARG43 3.3 21.3 1.0
CA A:PHE45 3.7 21.9 1.0
O A:HOH418 3.7 22.0 1.0
CZ A:ARG43 3.7 24.9 1.0
C A:PHE45 3.9 19.1 1.0
CD1 A:TYR46 4.0 25.4 1.0
OD1 A:ASP51 4.1 50.0 1.0
CD2 A:PHE45 4.1 27.3 1.0
O A:ASP44 4.1 19.4 1.0
CA A:TYR46 4.1 20.6 1.0
CE1 A:TYR46 4.2 21.3 1.0
CB A:PHE45 4.3 24.3 1.0
CG A:PHE45 4.4 24.0 1.0
CG A:TYR46 4.5 23.0 1.0
N A:PHE45 4.7 19.3 1.0
CZ A:TYR46 4.8 20.0 1.0
CE2 A:PHE45 4.8 26.6 1.0
C A:ASP44 4.8 19.7 1.0
CB A:TYR46 5.0 20.0 1.0

Chlorine binding site 3 out of 3 in 4gk8

Go back to Chlorine Binding Sites List in 4gk8
Chlorine binding site 3 out of 3 in the Crystal Structure of Histidinol Phosphate Phosphatase (Hisk) From Lactococcus Lactis Subsp. Lactis IL1403 Complexed with Zn and L- Histidinol Arsenate


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of Histidinol Phosphate Phosphatase (Hisk) From Lactococcus Lactis Subsp. Lactis IL1403 Complexed with Zn and L- Histidinol Arsenate within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl308

b:24.9
occ:1.00
 N A:GLU147 3.2 21.7 1.0
ND2 A:ASN93 3.4 22.5 1.0
CE A:LYS89 3.6 29.9 1.0
CD1 A:PHE146 3.7 24.0 1.0
N A:ASN148 3.7 18.1 1.0
CA A:GLU147 4.0 22.0 1.0
CB A:GLU147 4.0 27.1 1.0
OD1 A:ASN93 4.0 20.6 1.0
CG A:GLU147 4.1 39.2 1.0
CA A:PHE146 4.1 21.0 1.0
CE1 A:PHE146 4.1 23.2 1.0
C A:PHE146 4.1 20.0 1.0
CG A:ASN93 4.2 23.8 1.0
NZ A:LYS89 4.2 30.1 1.0
CB A:ASN148 4.2 20.7 1.0
C A:GLU147 4.3 19.4 1.0
CG A:PHE146 4.4 20.3 1.0
CA A:ASN148 4.6 18.9 1.0
CB A:PHE146 4.8 19.0 1.0
CD A:LYS89 4.8 24.4 1.0
O A:ASN145 4.9 25.6 1.0
CG A:LYS89 4.9 23.4 1.0
CZ A:PHE146 5.0 16.5 1.0

Reference:

S.V.Ghodge, A.A.Fedorov, E.V.Fedorov, B.Hillerich, R.Seidel, S.C.Almo, F.M.Raushel. Structural and Mechanistic Characterization of L-Histidinol Phosphate Phosphatase From the Polymerase and Histidinol Phosphatase Family of Proteins. Biochemistry V. 52 1101 2013.
ISSN: ISSN 0006-2960
PubMed: 23327428
DOI: 10.1021/BI301496P
Page generated: Sun Jul 21 14:44:41 2024

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