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Chlorine in PDB 4gkh: Crystal Structure of the Aminoglycoside Phosphotransferase Aph(3')-Ia, with Substrate Kanamycin and Small Molecule Inhibitor 1-Na-PP1
Enzymatic activity of Crystal Structure of the Aminoglycoside Phosphotransferase Aph(3')-Ia, with Substrate Kanamycin and Small Molecule Inhibitor 1-Na-PP1
All present enzymatic activity of Crystal Structure of the Aminoglycoside Phosphotransferase Aph(3')-Ia, with Substrate Kanamycin and Small Molecule Inhibitor 1-Na-PP1:
2.7.1.95;
2.7.1.95;
Protein crystallography data
The structure of Crystal Structure of the Aminoglycoside Phosphotransferase Aph(3')-Ia, with Substrate Kanamycin and Small Molecule Inhibitor 1-Na-PP1, PDB code: 4gkh
was solved by
P.J.Stogios,
E.Evdokimova,
Z.Wawrzak,
G.Minasov,
O.Egorova,
R.Di Leo,
T.Shakya,
P.Spanogiannopoulos,
N.Todorovic,
A.Capretta,
G.D.Wright,
A.Savchenko,
W.F.Anderson,
Center For Structural Genomics Ofinfectious Diseases (Csgid),
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 54.78 / 1.86 |
| Space group | P 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 97.185, 97.298, 112.738, 102.97, 106.21, 112.66 |
| R / Rfree (%) | 16.4 / 21.6 |
Other elements in 4gkh:
The structure of Crystal Structure of the Aminoglycoside Phosphotransferase Aph(3')-Ia, with Substrate Kanamycin and Small Molecule Inhibitor 1-Na-PP1 also contains other interesting chemical elements:
| Sodium | (Na) | 14 atoms |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of the Aminoglycoside Phosphotransferase Aph(3')-Ia, with Substrate Kanamycin and Small Molecule Inhibitor 1-Na-PP1
(pdb code 4gkh). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of the Aminoglycoside Phosphotransferase Aph(3')-Ia, with Substrate Kanamycin and Small Molecule Inhibitor 1-Na-PP1, PDB code: 4gkh:
Jump to Chlorine binding site number: 1; 2;
In total 2 binding sites of Chlorine where determined in the Crystal Structure of the Aminoglycoside Phosphotransferase Aph(3')-Ia, with Substrate Kanamycin and Small Molecule Inhibitor 1-Na-PP1, PDB code: 4gkh:
Jump to Chlorine binding site number: 1; 2;
Chlorine binding site 1 out of 2 in 4gkh
Go back to
Chlorine Binding Sites List in 4gkh
Chlorine binding site 1 out
of 2 in the Crystal Structure of the Aminoglycoside Phosphotransferase Aph(3')-Ia, with Substrate Kanamycin and Small Molecule Inhibitor 1-Na-PP1
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Crystal Structure of the Aminoglycoside Phosphotransferase Aph(3')-Ia, with Substrate Kanamycin and Small Molecule Inhibitor 1-Na-PP1 within 5.0Å range:
|
Chlorine binding site 2 out of 2 in 4gkh
Go back to
Chlorine Binding Sites List in 4gkh
Chlorine binding site 2 out
of 2 in the Crystal Structure of the Aminoglycoside Phosphotransferase Aph(3')-Ia, with Substrate Kanamycin and Small Molecule Inhibitor 1-Na-PP1
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of Crystal Structure of the Aminoglycoside Phosphotransferase Aph(3')-Ia, with Substrate Kanamycin and Small Molecule Inhibitor 1-Na-PP1 within 5.0Å range:
|
Reference:
P.J.Stogios,
P.Spanogiannopoulos,
E.Evdokimova,
O.Egorova,
T.Shakya,
N.Todorovic,
A.Capretta,
G.D.Wright,
A.Savchenko.
Structure-Guided Optimization of Protein Kinase Inhibitors Reverses Aminoglycoside Antibiotic Resistance. Biochem.J. V. 454 191 2013.
ISSN: ISSN 0264-6021
PubMed: 23758273
DOI: 10.1042/BJ20130317
Page generated: Sun Jul 21 14:45:29 2024
ISSN: ISSN 0264-6021
PubMed: 23758273
DOI: 10.1042/BJ20130317
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