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Chlorine in PDB 4gwm: Crystal Structure of Human Promeprin Beta

Enzymatic activity of Crystal Structure of Human Promeprin Beta

All present enzymatic activity of Crystal Structure of Human Promeprin Beta:
3.4.24.63;

Protein crystallography data

The structure of Crystal Structure of Human Promeprin Beta, PDB code: 4gwm was solved by J.L.Arolas, C.Broder, T.Jefferson, T.Guevara, E.E.Sterchi, W.Bode, W.Stocker, C.Becker-Pauly, F.X.Gomis-Ruth, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 48.45 / 1.85
Space group P 1
Cell size a, b, c (Å), α, β, γ (°) 69.620, 71.120, 85.740, 74.87, 80.08, 65.13
R / Rfree (%) 16.8 / 18.8

Other elements in 4gwm:

The structure of Crystal Structure of Human Promeprin Beta also contains other interesting chemical elements:

Zinc (Zn) 2 atoms
Sodium (Na) 2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Human Promeprin Beta (pdb code 4gwm). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 5 binding sites of Chlorine where determined in the Crystal Structure of Human Promeprin Beta, PDB code: 4gwm:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5;

Chlorine binding site 1 out of 5 in 4gwm

Go back to Chlorine Binding Sites List in 4gwm
Chlorine binding site 1 out of 5 in the Crystal Structure of Human Promeprin Beta


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Human Promeprin Beta within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl728

b:28.6
occ:0.80
O A:HOH808 3.1 30.0 1.0
N A:SER266 3.2 21.9 1.0
N A:GLU268 3.4 26.9 1.0
N A:PHE267 3.5 20.2 1.0
O A:HOH1052 3.6 67.6 1.0
CA A:SER266 3.8 22.0 1.0
C A:SER266 3.8 23.6 1.0
SG A:CYS273 3.8 40.6 1.0
CB A:SER266 3.8 27.1 1.0
CB A:GLU268 4.0 32.3 1.0
C A:CYS265 4.2 26.6 1.0
CA A:GLU268 4.2 29.4 1.0
CA A:PHE267 4.3 20.7 1.0
CG A:GLU268 4.3 46.3 1.0
C A:PHE267 4.3 26.3 1.0
CA A:CYS265 4.3 27.5 1.0
O A:HOH911 4.7 30.8 1.0
O A:SER266 4.7 22.4 1.0
N A:LEU269 4.7 27.7 1.0
OG A:SER266 4.7 35.0 1.0
SG A:CYS265 4.8 37.5 1.0
O A:SER264 4.9 25.3 1.0
C A:GLU268 5.0 32.9 1.0

Chlorine binding site 2 out of 5 in 4gwm

Go back to Chlorine Binding Sites List in 4gwm
Chlorine binding site 2 out of 5 in the Crystal Structure of Human Promeprin Beta


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Human Promeprin Beta within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl729

b:28.2
occ:0.92
OG A:SER517 3.0 28.0 1.0
O A:HOH851 3.0 23.1 1.0
NE2 A:GLN515 3.2 22.8 1.0
ND2 A:ASN93 3.2 28.5 1.0
CG2 A:VAL90 3.9 29.6 1.0
CG A:GLN515 3.9 30.3 1.0
CB A:SER517 3.9 29.2 1.0
CB A:ILE147 3.9 26.0 1.0
CB A:ASN93 3.9 25.4 1.0
CD A:GLN515 4.0 33.2 1.0
CG A:ASN93 4.0 41.6 1.0
CG1 A:VAL90 4.2 27.4 1.0
CA A:VAL90 4.2 25.8 1.0
CD1 A:ILE147 4.3 25.8 1.0
CB A:VAL90 4.3 29.5 1.0
N A:SER517 4.3 26.0 1.0
CG2 A:THR498 4.3 29.9 1.0
CG2 A:ILE147 4.5 25.3 1.0
CG1 A:ILE147 4.5 26.2 1.0
C A:ARG516 4.6 29.2 1.0
O A:VAL90 4.7 27.1 1.0
N A:ILE147 4.7 24.4 1.0
CA A:SER517 4.7 26.7 1.0
OG1 A:THR498 4.8 34.7 1.0
CA A:ILE147 4.8 22.8 1.0
O A:GLN515 4.8 27.9 1.0
O A:HOH850 4.9 28.8 1.0
CA A:ARG516 4.9 25.4 1.0
CB A:GLN515 4.9 25.6 1.0
C A:GLN515 5.0 28.2 1.0

Chlorine binding site 3 out of 5 in 4gwm

Go back to Chlorine Binding Sites List in 4gwm
Chlorine binding site 3 out of 5 in the Crystal Structure of Human Promeprin Beta


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of Human Promeprin Beta within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl727

b:18.2
occ:0.93
OG B:SER517 3.0 20.8 1.0
O B:HOH868 3.1 17.4 1.0
ND2 B:ASN93 3.1 20.3 1.0
NE2 B:GLN515 3.1 18.1 1.0
CG B:GLN515 3.8 19.6 1.0
CB B:SER517 3.9 18.9 1.0
CB B:ASN93 3.9 19.5 1.0
CG2 B:VAL90 3.9 17.7 1.0
CD B:GLN515 4.0 28.2 1.0
CB B:ILE147 4.0 16.0 1.0
CG B:ASN93 4.0 30.0 1.0
CG1 B:VAL90 4.2 18.4 1.0
CA B:VAL90 4.2 14.6 1.0
CG2 B:THR498 4.2 19.2 1.0
CD1 B:ILE147 4.3 17.1 1.0
N B:SER517 4.3 15.8 1.0
CB B:VAL90 4.4 18.2 1.0
C B:ARG516 4.5 20.3 1.0
CG1 B:ILE147 4.5 15.8 1.0
CG2 B:ILE147 4.5 18.2 1.0
CA B:SER517 4.7 16.4 1.0
O B:VAL90 4.8 18.7 1.0
OG1 B:THR498 4.8 22.7 1.0
O B:GLN515 4.8 16.8 1.0
N B:ILE147 4.8 15.0 1.0
CA B:ARG516 4.8 14.7 1.0
CB B:GLN515 4.8 14.9 1.0
O B:HOH864 4.9 20.1 1.0
CA B:ILE147 4.9 14.1 1.0
C B:GLN515 4.9 19.3 1.0
N B:ARG516 4.9 14.3 1.0
O B:ARG516 5.0 18.6 1.0

Chlorine binding site 4 out of 5 in 4gwm

Go back to Chlorine Binding Sites List in 4gwm
Chlorine binding site 4 out of 5 in the Crystal Structure of Human Promeprin Beta


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Crystal Structure of Human Promeprin Beta within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl728

b:32.0
occ:0.87
O B:HOH829 3.1 42.7 1.0
ND2 B:ASN114 3.2 28.9 1.0
O B:HOH1184 3.3 56.9 1.0
ND2 B:ASN130 3.3 24.3 1.0
NH1 B:ARG132 3.7 63.2 1.0
CB B:ASN114 3.8 25.2 1.0
CD B:PRO72 3.9 25.5 1.0
CG B:PRO72 4.0 30.4 1.0
CG B:ASN114 4.0 28.8 1.0
CG2 B:THR113 4.4 35.1 1.0
CZ B:ARG132 4.4 76.3 1.0
CG B:ASN130 4.4 32.5 1.0
NH2 B:ARG132 4.5 63.0 1.0
N B:ASN114 4.6 26.2 1.0
O B:HOH830 4.6 31.5 1.0
OD1 B:ASN130 4.7 26.5 1.0
CE3 B:TRP71 4.8 20.7 1.0
CA B:ASN114 4.8 25.4 1.0
O B:ASN114 4.9 24.4 1.0
CZ3 B:TRP71 4.9 22.2 1.0
N B:PRO72 5.0 23.8 1.0

Chlorine binding site 5 out of 5 in 4gwm

Go back to Chlorine Binding Sites List in 4gwm
Chlorine binding site 5 out of 5 in the Crystal Structure of Human Promeprin Beta


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Crystal Structure of Human Promeprin Beta within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl729

b:20.4
occ:0.79
O B:HOH1152 2.8 52.3 1.0
O B:HOH1167 3.0 49.0 1.0
O B:HOH885 3.0 27.0 1.0
NH1 B:ARG511 3.2 19.0 1.0
O B:HOH1147 3.3 33.3 1.0
NE2 B:GLN342 3.4 20.6 1.0
CD1 B:LEU502 3.7 19.9 1.0
O B:HOH1221 3.9 56.8 1.0
CD1 B:ILE508 4.1 38.5 1.0
CD B:ARG511 4.1 15.2 1.0
CG1 B:ILE508 4.2 23.9 1.0
OE1 B:GLN342 4.2 21.3 1.0
CD B:GLN342 4.2 30.0 1.0
CZ B:ARG511 4.3 19.5 1.0
CD1 B:LEU582 4.6 24.3 1.0
NE B:ARG511 4.7 15.8 1.0
O B:HOH883 4.7 27.6 1.0

Reference:

J.L.Arolas, C.Broder, T.Jefferson, T.Guevara, E.E.Sterchi, W.Bode, W.Stocker, C.Becker-Pauly, F.X.Gomis-Ruth. Structural Basis For the Sheddase Function of Human Meprin Beta Metalloproteinase at the Plasma Membrane Proc.Natl.Acad.Sci.Usa V. 109 16131 2012.
ISSN: ISSN 0027-8424
PubMed: 22988105
DOI: 10.1073/PNAS.1211076109
Page generated: Sat Dec 12 10:40:59 2020

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