Chlorine in PDB 4hbt: Crystal Structure of Native Ctx-M-15 Extended-Spectrum Beta-Lactamase

All present enzymatic activity of Crystal Structure of Native Ctx-M-15 Extended-Spectrum Beta-Lactamase:
3.5.2.6;

The structure of Crystal Structure of Native Ctx-M-15 Extended-Spectrum Beta-Lactamase, PDB code: 4hbt was solved by J.D.Docquier, M.Benvenuti, J.M.Bruneau, G.M.Rossolini, C.Miossec, M.T.Black, S.Mangani, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.27 / 1.10
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	44.698, 45.720, 117.086, 90.00, 90.00, 90.00
R / Rfree (%)	11.7 / 13.6

The binding sites of Chlorine atom in the Crystal Structure of Native Ctx-M-15 Extended-Spectrum Beta-Lactamase (pdb code 4hbt). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Native Ctx-M-15 Extended-Spectrum Beta-Lactamase, PDB code: 4hbt:

Chlorine binding site 1 out of 1 in the Crystal Structure of Native Ctx-M-15 Extended-Spectrum Beta-Lactamase


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Native Ctx-M-15 Extended-Spectrum Beta-Lactamase within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl314 b:10.0 occ:1.00 O A:HOH537 3.2 12.8 1.0 N A:ALA227 3.3 7.8 1.0 CA A:PRO226 3.7 7.1 1.0 CB A:ALA227 4.0 11.3 1.0 C A:PRO226 4.0 7.0 1.0 CB A:PRO226 4.1 7.8 1.0 CA A:ALA227 4.3 9.9 1.0

S.D.Lahiri, S.Mangani, T.Durand-Reville, M.Benvenuti, F.De Luca, G.Sanyal, J.D.Docquier. Structural Insight Into Potent Broad-Spectrum Inhibition with Reversible Recyclization Mechanism: Avibactam in Complex with Ctx-M-15 and Pseudomonas Aeruginosa Ampc Beta-Lactamases Antimicrob.Agents Chemother. V. 57 2496 2013.
ISSN: ISSN 0066-4804
PubMed: 23439634
DOI: 10.1128/AAC.02247-12