Atomistry » Chlorine » PDB 4he0-4hmq » 4hfh
Atomistry »
  Chlorine »
    PDB 4he0-4hmq »
      4hfh »

Chlorine in PDB 4hfh: The Glic Pentameric Ligand-Gated Ion Channel (Wild-Type) Complexed to Bromoform

Protein crystallography data

The structure of The Glic Pentameric Ligand-Gated Ion Channel (Wild-Type) Complexed to Bromoform, PDB code: 4hfh was solved by L.Sauguet, R.J.Howard, L.Malherbe, U.S.Lee, P.J.Corringer, R.A.Harris, M.Delarue, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 21.71 / 2.65
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 181.000, 132.650, 159.270, 90.00, 102.16, 90.00
R / Rfree (%) 20.2 / 21.3

Other elements in 4hfh:

The structure of The Glic Pentameric Ligand-Gated Ion Channel (Wild-Type) Complexed to Bromoform also contains other interesting chemical elements:

Bromine (Br) 45 atoms
Sodium (Na) 5 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the The Glic Pentameric Ligand-Gated Ion Channel (Wild-Type) Complexed to Bromoform (pdb code 4hfh). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 7 binding sites of Chlorine where determined in the The Glic Pentameric Ligand-Gated Ion Channel (Wild-Type) Complexed to Bromoform, PDB code: 4hfh:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; 7;

Chlorine binding site 1 out of 7 in 4hfh

Go back to Chlorine Binding Sites List in 4hfh
Chlorine binding site 1 out of 7 in the The Glic Pentameric Ligand-Gated Ion Channel (Wild-Type) Complexed to Bromoform


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of The Glic Pentameric Ligand-Gated Ion Channel (Wild-Type) Complexed to Bromoform within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl406

b:65.6
occ:1.00
 N A:PHE78 3.4 61.2 1.0
N A:ARG85 3.5 67.4 1.0
NH1 A:ARG85 3.5 63.7 1.0
CD2 A:PHE78 3.7 73.2 1.0
CB A:PHE78 3.9 64.6 1.0
CA A:ALA84 3.9 67.1 1.0
CA A:ARG77 4.1 59.2 1.0
CG A:ARG85 4.1 69.8 1.0
CG2 A:VAL81 4.1 59.1 1.0
CB A:ARG85 4.1 64.7 1.0
CA A:PHE78 4.2 61.4 1.0
C A:ARG77 4.2 63.8 1.0
C A:ALA84 4.2 72.3 1.0
CD A:ARG85 4.3 73.1 1.0
CG A:PHE78 4.3 68.9 1.0
CB A:ARG77 4.3 57.7 1.0
O A:PHE78 4.3 60.1 1.0
CB A:ALA84 4.4 68.1 1.0
CA A:ARG85 4.4 66.6 1.0
CZ A:ARG85 4.6 79.1 1.0
CG A:ARG77 4.6 64.7 1.0
CE2 A:PHE78 4.7 77.2 1.0
C A:PHE78 4.8 61.5 1.0
NE A:ARG85 4.9 75.2 1.0

Chlorine binding site 2 out of 7 in 4hfh

Go back to Chlorine Binding Sites List in 4hfh
Chlorine binding site 2 out of 7 in the The Glic Pentameric Ligand-Gated Ion Channel (Wild-Type) Complexed to Bromoform


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of The Glic Pentameric Ligand-Gated Ion Channel (Wild-Type) Complexed to Bromoform within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl407

b:77.9
occ:1.00
 N A:LEU180 3.2 59.8 1.0
OD1 A:ASN139 3.3 73.0 1.0
CB A:LEU180 3.8 59.1 1.0
CA A:ARG179 3.8 61.8 1.0
C A:ARG179 4.0 64.0 1.0
CA A:LEU180 4.1 58.8 1.0
O A:ASP178 4.2 70.1 1.0
CG A:ASN139 4.4 86.6 1.0
CB A:SER134 4.5 67.6 1.0
CD A:ARG179 4.5 78.7 1.0
CB A:ARG179 4.6 60.2 1.0
N A:ARG179 4.8 63.3 1.0
C A:ASP178 4.8 69.4 1.0
CG A:ARG179 4.9 68.0 1.0

Chlorine binding site 3 out of 7 in 4hfh

Go back to Chlorine Binding Sites List in 4hfh
Chlorine binding site 3 out of 7 in the The Glic Pentameric Ligand-Gated Ion Channel (Wild-Type) Complexed to Bromoform


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of The Glic Pentameric Ligand-Gated Ion Channel (Wild-Type) Complexed to Bromoform within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl408

b:93.6
occ:1.00
 N A:ALA175 3.6 59.0 1.0
CB A:ALA175 3.9 61.1 1.0
CA A:PHE174 4.2 59.7 1.0
C A:PHE174 4.3 62.2 1.0
CA A:ALA175 4.4 59.1 1.0
CB A:PHE174 4.5 60.7 1.0
O A:ALA175 5.0 62.9 1.0

Chlorine binding site 4 out of 7 in 4hfh

Go back to Chlorine Binding Sites List in 4hfh
Chlorine binding site 4 out of 7 in the The Glic Pentameric Ligand-Gated Ion Channel (Wild-Type) Complexed to Bromoform


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of The Glic Pentameric Ligand-Gated Ion Channel (Wild-Type) Complexed to Bromoform within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl406

b:66.0
occ:1.00
 N B:PHE78 3.3 60.1 1.0
NH1 B:ARG85 3.5 65.0 1.0
CD2 B:PHE78 3.5 69.9 1.0
N B:ARG85 3.5 71.2 1.0
CB B:PHE78 3.8 62.7 1.0
CG B:ARG85 4.0 71.2 1.0
CA B:ARG77 4.0 58.5 1.0
CA B:ALA84 4.1 73.1 1.0
CB B:ARG85 4.1 67.7 1.0
CA B:PHE78 4.1 60.5 1.0
CG2 B:VAL81 4.1 60.0 1.0
CG B:PHE78 4.1 65.8 1.0
C B:ARG77 4.1 62.0 1.0
CD B:ARG85 4.1 72.9 1.0
C B:ALA84 4.3 76.2 1.0
O B:PHE78 4.3 64.9 1.0
CB B:ARG77 4.3 57.3 1.0
CA B:ARG85 4.4 70.3 1.0
CZ B:ARG85 4.5 80.0 1.0
CB B:ALA84 4.5 74.6 1.0
CE2 B:PHE78 4.6 73.5 1.0
CG B:ARG77 4.7 65.8 1.0
C B:PHE78 4.7 64.0 1.0
NE B:ARG85 4.8 73.2 1.0

Chlorine binding site 5 out of 7 in 4hfh

Go back to Chlorine Binding Sites List in 4hfh
Chlorine binding site 5 out of 7 in the The Glic Pentameric Ligand-Gated Ion Channel (Wild-Type) Complexed to Bromoform


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of The Glic Pentameric Ligand-Gated Ion Channel (Wild-Type) Complexed to Bromoform within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl406

b:63.2
occ:1.00
 N C:PHE78 3.4 64.1 1.0
NH1 C:ARG85 3.5 57.7 1.0
N C:ARG85 3.5 69.5 1.0
CD2 C:PHE78 3.7 73.4 1.0
CB C:PHE78 3.9 66.4 1.0
CA C:ALA84 4.0 69.7 1.0
CG C:ARG85 4.0 66.6 1.0
CA C:ARG77 4.1 62.1 1.0
CG2 C:VAL81 4.1 64.5 1.0
CB C:ARG85 4.1 65.9 1.0
CA C:PHE78 4.2 64.1 1.0
CD C:ARG85 4.2 66.9 1.0
C C:ARG77 4.2 66.6 1.0
C C:ALA84 4.3 73.7 1.0
CG C:PHE78 4.3 69.5 1.0
CB C:ARG77 4.3 60.8 1.0
O C:PHE78 4.4 65.1 1.0
CA C:ARG85 4.4 68.5 1.0
CB C:ALA84 4.5 70.9 1.0
CZ C:ARG85 4.6 77.2 1.0
CG C:ARG77 4.6 68.4 1.0
CE2 C:PHE78 4.7 76.9 1.0
C C:PHE78 4.8 65.5 1.0
NE C:ARG85 4.8 67.7 1.0

Chlorine binding site 6 out of 7 in 4hfh

Go back to Chlorine Binding Sites List in 4hfh
Chlorine binding site 6 out of 7 in the The Glic Pentameric Ligand-Gated Ion Channel (Wild-Type) Complexed to Bromoform


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of The Glic Pentameric Ligand-Gated Ion Channel (Wild-Type) Complexed to Bromoform within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cl406

b:66.8
occ:1.00
 N D:PHE78 3.3 58.3 1.0
NH1 D:ARG85 3.4 61.8 1.0
CD2 D:PHE78 3.5 68.6 1.0
N D:ARG85 3.5 66.5 1.0
CB D:PHE78 3.8 61.1 1.0
CG D:ARG85 3.9 66.7 1.0
CA D:ARG77 4.0 55.5 1.0
CB D:ARG85 4.0 63.0 1.0
CD D:ARG85 4.1 67.6 1.0
CG D:PHE78 4.1 64.5 1.0
CA D:ALA84 4.1 66.9 1.0
C D:ARG77 4.1 60.1 1.0
CA D:PHE78 4.1 58.5 1.0
CG2 D:VAL81 4.2 61.3 1.0
C D:ALA84 4.3 71.0 1.0
CB D:ARG77 4.3 53.0 1.0
CA D:ARG85 4.4 65.8 1.0
O D:PHE78 4.4 61.3 1.0
CZ D:ARG85 4.4 78.3 1.0
CE2 D:PHE78 4.5 72.5 1.0
CB D:ALA84 4.6 68.0 1.0
NE D:ARG85 4.7 72.7 1.0
CG D:ARG77 4.7 57.0 1.0
C D:PHE78 4.8 61.1 1.0
O D:ILE76 4.9 60.8 1.0

Chlorine binding site 7 out of 7 in 4hfh

Go back to Chlorine Binding Sites List in 4hfh
Chlorine binding site 7 out of 7 in the The Glic Pentameric Ligand-Gated Ion Channel (Wild-Type) Complexed to Bromoform


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 7 of The Glic Pentameric Ligand-Gated Ion Channel (Wild-Type) Complexed to Bromoform within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Cl406

b:71.0
occ:1.00
 N E:PHE78 3.3 62.3 1.0
NH1 E:ARG85 3.4 65.6 1.0
N E:ARG85 3.6 70.1 1.0
CD2 E:PHE78 3.6 71.8 1.0
CB E:PHE78 3.8 64.5 1.0
CA E:ARG77 4.0 61.2 1.0
CG E:ARG85 4.0 72.1 1.0
CA E:ALA84 4.1 71.7 1.0
CA E:PHE78 4.1 62.0 1.0
C E:ARG77 4.1 65.1 1.0
CB E:ARG85 4.1 66.6 1.0
CG2 E:VAL81 4.1 64.1 1.0
CG E:PHE78 4.2 67.7 1.0
CD E:ARG85 4.2 69.3 1.0
CB E:ARG77 4.3 59.3 1.0
C E:ALA84 4.3 75.4 1.0
O E:PHE78 4.3 63.5 1.0
CA E:ARG85 4.5 69.1 1.0
CZ E:ARG85 4.5 83.0 1.0
CB E:ALA84 4.6 72.9 1.0
CE2 E:PHE78 4.6 75.3 1.0
CG E:ARG77 4.6 68.2 1.0
C E:PHE78 4.7 63.5 1.0
NE E:ARG85 4.8 71.4 1.0
O E:ILE76 5.0 67.0 1.0

Reference:

L.Sauguet, R.J.Howard, L.Malherbe, U.S.Lee, P.J.Corringer, R.A.Harris, M.Delarue. Structural Basis For Potentiation By Alcohols and Anaesthetics in A Ligand-Gated Ion Channel. Nat Commun V. 4 1697 2013.
ISSN: ESSN 2041-1723
PubMed: 23591864
DOI: 10.1038/NCOMMS2682
Page generated: Sun Jul 21 15:47:52 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy