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Atomistry » Chlorine » PDB 4hmr-4hvt » 4hog | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 4hmr-4hvt » 4hog » |
Chlorine in PDB 4hog: Candida Glabrata Dihydrofolate Reductase Complexed with Nadph and 5- [3-(2-Methoxy-4-Phenylphenyl)But-1-Yn-1-Yl]-6-Methylpyrimidine-2,4- Diamine (UCP111H)Protein crystallography data
The structure of Candida Glabrata Dihydrofolate Reductase Complexed with Nadph and 5- [3-(2-Methoxy-4-Phenylphenyl)But-1-Yn-1-Yl]-6-Methylpyrimidine-2,4- Diamine (UCP111H), PDB code: 4hog
was solved by
J.L.Paulsen,
A.C.Anderson,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Candida Glabrata Dihydrofolate Reductase Complexed with Nadph and 5- [3-(2-Methoxy-4-Phenylphenyl)But-1-Yn-1-Yl]-6-Methylpyrimidine-2,4- Diamine (UCP111H)
(pdb code 4hog). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Candida Glabrata Dihydrofolate Reductase Complexed with Nadph and 5- [3-(2-Methoxy-4-Phenylphenyl)But-1-Yn-1-Yl]-6-Methylpyrimidine-2,4- Diamine (UCP111H), PDB code: 4hog: Jump to Chlorine binding site number: 1; 2; 3; 4; Chlorine binding site 1 out of 4 in 4hogGo back to Chlorine Binding Sites List in 4hog
Chlorine binding site 1 out
of 4 in the Candida Glabrata Dihydrofolate Reductase Complexed with Nadph and 5- [3-(2-Methoxy-4-Phenylphenyl)But-1-Yn-1-Yl]-6-Methylpyrimidine-2,4- Diamine (UCP111H)
Mono view Stereo pair view
Chlorine binding site 2 out of 4 in 4hogGo back to Chlorine Binding Sites List in 4hog
Chlorine binding site 2 out
of 4 in the Candida Glabrata Dihydrofolate Reductase Complexed with Nadph and 5- [3-(2-Methoxy-4-Phenylphenyl)But-1-Yn-1-Yl]-6-Methylpyrimidine-2,4- Diamine (UCP111H)
Mono view Stereo pair view
Chlorine binding site 3 out of 4 in 4hogGo back to Chlorine Binding Sites List in 4hog
Chlorine binding site 3 out
of 4 in the Candida Glabrata Dihydrofolate Reductase Complexed with Nadph and 5- [3-(2-Methoxy-4-Phenylphenyl)But-1-Yn-1-Yl]-6-Methylpyrimidine-2,4- Diamine (UCP111H)
Mono view Stereo pair view
Chlorine binding site 4 out of 4 in 4hogGo back to Chlorine Binding Sites List in 4hog
Chlorine binding site 4 out
of 4 in the Candida Glabrata Dihydrofolate Reductase Complexed with Nadph and 5- [3-(2-Methoxy-4-Phenylphenyl)But-1-Yn-1-Yl]-6-Methylpyrimidine-2,4- Diamine (UCP111H)
Mono view Stereo pair view
Reference:
N.G-Dayanandan,
J.L.Paulsen,
K.Viswanathan,
S.Keshipeddy,
M.N.Lombardo,
W.Zhou,
K.M.Lamb,
A.E.Sochia,
J.B.Alverson,
N.D.Priestley,
D.L.Wright,
A.C.Anderson.
Propargyl-Linked Antifolates Are Dual Inhibitors of Candida Albicans and Candida Glabrata. J.Med.Chem. V. 57 2643 2014.
Page generated: Sat Dec 12 10:43:17 2020
ISSN: ISSN 0022-2623 PubMed: 24568657 DOI: 10.1021/JM401916J |
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