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Chlorine in PDB 4hyv: Pyruvate Kinase (Pyk) From Trypanosoma Brucei in the Presence of Magnesium, Pep and F26BP

Enzymatic activity of Pyruvate Kinase (Pyk) From Trypanosoma Brucei in the Presence of Magnesium, Pep and F26BP

All present enzymatic activity of Pyruvate Kinase (Pyk) From Trypanosoma Brucei in the Presence of Magnesium, Pep and F26BP:
2.7.1.40;

Protein crystallography data

The structure of Pyruvate Kinase (Pyk) From Trypanosoma Brucei in the Presence of Magnesium, Pep and F26BP, PDB code: 4hyv was solved by W.Zhong, H.P.Morgan, I.W.Mcnae, P.A.M.Michels, L.A.Fothergill-Gilmore, M.D.Walkinshaw, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 65.17 / 2.30
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 103.410, 108.930, 263.340, 90.00, 90.00, 90.00
R / Rfree (%) 14.6 / 18.8

Other elements in 4hyv:

The structure of Pyruvate Kinase (Pyk) From Trypanosoma Brucei in the Presence of Magnesium, Pep and F26BP also contains other interesting chemical elements:

Magnesium (Mg) 2 atoms
Potassium (K) 2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Pyruvate Kinase (Pyk) From Trypanosoma Brucei in the Presence of Magnesium, Pep and F26BP (pdb code 4hyv). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Pyruvate Kinase (Pyk) From Trypanosoma Brucei in the Presence of Magnesium, Pep and F26BP, PDB code: 4hyv:

Chlorine binding site 1 out of 1 in 4hyv

Go back to Chlorine Binding Sites List in 4hyv
Chlorine binding site 1 out of 1 in the Pyruvate Kinase (Pyk) From Trypanosoma Brucei in the Presence of Magnesium, Pep and F26BP


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Pyruvate Kinase (Pyk) From Trypanosoma Brucei in the Presence of Magnesium, Pep and F26BP within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl1005

b:82.2
occ:0.50
NZ B:LYS96 3.5 60.9 1.0
CE B:LYS96 4.2 61.8 1.0
CB B:VAL119 4.7 43.0 1.0
CG2 B:VAL119 4.8 37.6 1.0
O B:HOH1212 4.9 39.2 1.0
O B:HOH1435 4.9 48.9 1.0
O B:VAL119 5.0 38.7 1.0

Reference:

W.Zhong, H.P.Morgan, I.W.Mcnae, P.A.Michels, L.A.Fothergill-Gilmore, M.D.Walkinshaw. `in Crystallo' Substrate Binding Triggers Major Domain Movements and Reveals Magnesium As A Co-Activator of Trypanosoma Brucei Pyruvate Kinase. Acta Crystallogr.,Sect.D V. 69 1768 2013.
ISSN: ISSN 0907-4449
PubMed: 23999300
DOI: 10.1107/S0907444913013875
Page generated: Sun Jul 21 16:14:56 2024

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