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Atomistry » Chlorine » PDB 4i1y-4ibc » 4i5i | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 4i1y-4ibc » 4i5i » |
Chlorine in PDB 4i5i: Crystal Structure of the SIRT1 Catalytic Domain Bound to Nad and An EX527 AnalogProtein crystallography data
The structure of Crystal Structure of the SIRT1 Catalytic Domain Bound to Nad and An EX527 Analog, PDB code: 4i5i
was solved by
X.Zhao,
D.Allison,
B.Condon,
F.Zhang,
T.Gheyi,
A.Zhang,
S.Ashok,
M.Russell,
I.Macewan,
Y.Qian,
J.A.Jamison,
J.G.Luz,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4i5i:
The structure of Crystal Structure of the SIRT1 Catalytic Domain Bound to Nad and An EX527 Analog also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of the SIRT1 Catalytic Domain Bound to Nad and An EX527 Analog
(pdb code 4i5i). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of the SIRT1 Catalytic Domain Bound to Nad and An EX527 Analog, PDB code: 4i5i: Jump to Chlorine binding site number: 1; 2; Chlorine binding site 1 out of 2 in 4i5iGo back to Chlorine Binding Sites List in 4i5i
Chlorine binding site 1 out
of 2 in the Crystal Structure of the SIRT1 Catalytic Domain Bound to Nad and An EX527 Analog
Mono view Stereo pair view
Chlorine binding site 2 out of 2 in 4i5iGo back to Chlorine Binding Sites List in 4i5i
Chlorine binding site 2 out
of 2 in the Crystal Structure of the SIRT1 Catalytic Domain Bound to Nad and An EX527 Analog
Mono view Stereo pair view
Reference:
X.Zhao,
D.Allison,
B.Condon,
F.Zhang,
T.Gheyi,
A.Zhang,
S.Ashok,
M.Russell,
I.Macewan,
Y.Qian,
J.A.Jamison,
J.G.Luz.
The 2.5 Angstrom Crystal Structure of the SIRT1 Catalytic Domain Bound to Nicotinamide Adenine Dinucleotide (Nad+) and An Indole (EX527 Analogue) Reveals A Novel Mechanism of Histone Deacetylase Inhibition. J.Med.Chem. V. 56 963 2013.
Page generated: Sat Dec 12 10:44:47 2020
ISSN: ISSN 0022-2623 PubMed: 23311358 DOI: 10.1021/JM301431Y |
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