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Chlorine in PDB 4i9h: Crystal Structure of Rabbit Ldha in Complex with AP28669
Enzymatic activity of Crystal Structure of Rabbit Ldha in Complex with AP28669
All present enzymatic activity of Crystal Structure of Rabbit Ldha in Complex with AP28669:
1.1.1.27;
1.1.1.27;
Protein crystallography data
The structure of Crystal Structure of Rabbit Ldha in Complex with AP28669, PDB code: 4i9h
was solved by
T.Zhou,
Z.G.Stephan,
A.Kohlmann,
F.Li,
L.Commodore,
M.T.Greenfield,
W.C.Shakespeare,
X.Zhu,
D.C.Dalgarno,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 50.00 / 2.17 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 83.866, 139.690, 138.810, 90.00, 94.43, 90.00 |
| R / Rfree (%) | 20.7 / 24.3 |
Other elements in 4i9h:
The structure of Crystal Structure of Rabbit Ldha in Complex with AP28669 also contains other interesting chemical elements:
| Fluorine | (F) | 8 atoms |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Rabbit Ldha in Complex with AP28669
(pdb code 4i9h). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 8 binding sites of Chlorine where determined in the Crystal Structure of Rabbit Ldha in Complex with AP28669, PDB code: 4i9h:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
In total 8 binding sites of Chlorine where determined in the Crystal Structure of Rabbit Ldha in Complex with AP28669, PDB code: 4i9h:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
Chlorine binding site 1 out of 8 in 4i9h
Go back to
Chlorine Binding Sites List in 4i9h
Chlorine binding site 1 out
of 8 in the Crystal Structure of Rabbit Ldha in Complex with AP28669
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Crystal Structure of Rabbit Ldha in Complex with AP28669 within 5.0Å range:
|
Chlorine binding site 2 out of 8 in 4i9h
Go back to
Chlorine Binding Sites List in 4i9h
Chlorine binding site 2 out
of 8 in the Crystal Structure of Rabbit Ldha in Complex with AP28669
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of Crystal Structure of Rabbit Ldha in Complex with AP28669 within 5.0Å range:
|
Chlorine binding site 3 out of 8 in 4i9h
Go back to
Chlorine Binding Sites List in 4i9h
Chlorine binding site 3 out
of 8 in the Crystal Structure of Rabbit Ldha in Complex with AP28669
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 3 of Crystal Structure of Rabbit Ldha in Complex with AP28669 within 5.0Å range:
|
Chlorine binding site 4 out of 8 in 4i9h
Go back to
Chlorine Binding Sites List in 4i9h
Chlorine binding site 4 out
of 8 in the Crystal Structure of Rabbit Ldha in Complex with AP28669
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 4 of Crystal Structure of Rabbit Ldha in Complex with AP28669 within 5.0Å range:
|
Chlorine binding site 5 out of 8 in 4i9h
Go back to
Chlorine Binding Sites List in 4i9h
Chlorine binding site 5 out
of 8 in the Crystal Structure of Rabbit Ldha in Complex with AP28669
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 5 of Crystal Structure of Rabbit Ldha in Complex with AP28669 within 5.0Å range:
|
Chlorine binding site 6 out of 8 in 4i9h
Go back to
Chlorine Binding Sites List in 4i9h
Chlorine binding site 6 out
of 8 in the Crystal Structure of Rabbit Ldha in Complex with AP28669
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 6 of Crystal Structure of Rabbit Ldha in Complex with AP28669 within 5.0Å range:
|
Chlorine binding site 7 out of 8 in 4i9h
Go back to
Chlorine Binding Sites List in 4i9h
Chlorine binding site 7 out
of 8 in the Crystal Structure of Rabbit Ldha in Complex with AP28669
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 7 of Crystal Structure of Rabbit Ldha in Complex with AP28669 within 5.0Å range:
|
Chlorine binding site 8 out of 8 in 4i9h
Go back to
Chlorine Binding Sites List in 4i9h
Chlorine binding site 8 out
of 8 in the Crystal Structure of Rabbit Ldha in Complex with AP28669
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 8 of Crystal Structure of Rabbit Ldha in Complex with AP28669 within 5.0Å range:
|
Reference:
A.Kohlmann,
S.G.Zech,
F.Li,
T.Zhou,
R.M.Squillace,
L.Commodore,
M.T.Greenfield,
X.Lu,
D.P.Miller,
W.S.Huang,
J.Qi,
R.M.Thomas,
Y.Wang,
S.Zhang,
R.Dodd,
S.Liu,
R.Xu,
Y.Xu,
J.J.Miret,
V.Rivera,
T.Clackson,
W.C.Shakespeare,
X.Zhu,
D.C.Dalgarno.
Fragment Growing and Linking Lead to Novel Nanomolar Lactate Dehydrogenase Inhibitors. J.Med.Chem. V. 56 1023 2013.
ISSN: ISSN 0022-2623
PubMed: 23302067
DOI: 10.1021/JM3014844
Page generated: Sat Dec 12 10:45:01 2020
ISSN: ISSN 0022-2623
PubMed: 23302067
DOI: 10.1021/JM3014844
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