Atomistry » Chlorine » PDB 4io3-4ixt » 4ixc
Atomistry »
  Chlorine »
    PDB 4io3-4ixt »
      4ixc »

Chlorine in PDB 4ixc: Crystal Structure of Human Glucokinase in Complex with A Small Molecule Activator.

Enzymatic activity of Crystal Structure of Human Glucokinase in Complex with A Small Molecule Activator.

All present enzymatic activity of Crystal Structure of Human Glucokinase in Complex with A Small Molecule Activator.:
2.7.1.2;

Protein crystallography data

The structure of Crystal Structure of Human Glucokinase in Complex with A Small Molecule Activator., PDB code: 4ixc was solved by D.J.Ogg, D.Hargreaves, S.Gerhardt, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 25.89 / 2.00
Space group P 41
Cell size a, b, c (Å), α, β, γ (°) 77.628, 77.628, 85.824, 90.00, 90.00, 90.00
R / Rfree (%) 18.6 / 24.9

Other elements in 4ixc:

The structure of Crystal Structure of Human Glucokinase in Complex with A Small Molecule Activator. also contains other interesting chemical elements:

Sodium (Na) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Human Glucokinase in Complex with A Small Molecule Activator. (pdb code 4ixc). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Human Glucokinase in Complex with A Small Molecule Activator., PDB code: 4ixc:

Chlorine binding site 1 out of 1 in 4ixc

Go back to Chlorine Binding Sites List in 4ixc
Chlorine binding site 1 out of 1 in the Crystal Structure of Human Glucokinase in Complex with A Small Molecule Activator.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Human Glucokinase in Complex with A Small Molecule Activator. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl503

b:37.7
occ:1.00
CL1 A:1JD503 0.0 37.7 1.0
C19 A:1JD503 1.7 36.6 1.0
C18 A:1JD503 2.6 38.5 1.0
C20 A:1JD503 2.7 38.5 1.0
N4 A:1JD503 2.9 31.2 1.0
N3 A:1JD503 3.3 30.6 1.0
C16 A:1JD503 3.5 28.5 1.0
CB A:SER69 3.6 26.2 1.0
OG A:SER69 3.7 27.2 1.0
CB A:LEU451 3.8 27.0 1.0
CG2 A:VAL455 3.8 24.5 1.0
O A:LEU451 3.8 25.3 1.0
CD2 A:LEU451 3.8 27.3 1.0
N7 A:1JD503 3.9 40.0 1.0
C21 A:1JD503 4.0 35.2 1.0
C15 A:1JD503 4.0 29.7 1.0
N5 A:1JD503 4.0 28.0 1.0
C14 A:1JD503 4.2 26.5 1.0
CA A:LEU451 4.3 24.6 1.0
CG A:LEU451 4.3 26.6 1.0
C A:LEU451 4.4 24.8 1.0
C22 A:1JD503 4.4 35.4 1.0
CD1 A:LEU451 4.7 30.3 1.0
O A:GLY68 4.7 28.7 1.0
C A:GLY68 4.8 29.2 1.0
CA A:SER69 4.8 27.1 1.0
N A:SER69 4.8 28.0 1.0
CD1 A:TYR215 4.9 32.3 1.0

Reference:

M.J.Waring, S.N.L.Bennett, S.Boyd, L.Campbell, R.D.M.Davies, S.Gerhardt, D.Hargreaves, N.G Martin, G.R.Robb, G.Wilkinson. Matched Triplicate Design Sets in the Optimisation of Glucokinase Activators Maximising Medicinal Chemistry Information Content To Be Published.
Page generated: Sun Jul 21 17:05:48 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy