Chlorine in PDB 4j5s: TARG1 (C6ORF130), Terminal Adp-Ribose Glycohydrolase 1 Adp-Ribose Complex

The structure of TARG1 (C6ORF130), Terminal Adp-Ribose Glycohydrolase 1 Adp-Ribose Complex, PDB code: 4j5s was solved by M.J.Schellenberg, C.D.Appel, J.Krahn, R.S.Williams, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	38.95 / 1.55
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	73.375, 56.221, 73.788, 90.00, 94.47, 90.00
R / Rfree (%)	13.7 / 17.5

The binding sites of Chlorine atom in the TARG1 (C6ORF130), Terminal Adp-Ribose Glycohydrolase 1 Adp-Ribose Complex (pdb code 4j5s). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the TARG1 (C6ORF130), Terminal Adp-Ribose Glycohydrolase 1 Adp-Ribose Complex, PDB code: 4j5s:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in the TARG1 (C6ORF130), Terminal Adp-Ribose Glycohydrolase 1 Adp-Ribose Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of TARG1 (C6ORF130), Terminal Adp-Ribose Glycohydrolase 1 Adp-Ribose Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl203 b:26.3 occ:1.00 OG A:SER38 3.1 24.1 1.0 O A:HOH487 3.1 31.2 0.6 N A:ARG42 3.2 23.9 1.0 N A:MET43 3.3 20.7 1.0 N A:SER38 3.4 17.2 1.0 N A:CYS41 3.7 21.9 0.5 CB A:SER38 3.8 21.8 1.0 N A:CYS41 3.8 21.6 0.5 O A:HOH499 3.8 41.8 1.0 CA A:CYS41 3.9 22.8 0.5 C A:CYS41 3.9 22.4 0.5 CA A:CYS41 3.9 22.3 0.5 C A:CYS41 4.0 23.2 0.5 CA A:ARG42 4.0 25.6 0.4 CA A:ARG42 4.0 25.5 0.4 CA A:SER38 4.0 20.0 1.0 CB A:ILE37 4.1 15.1 1.0 O A:SER38 4.1 19.3 1.0 CB A:ARG42 4.1 31.0 0.4 CB A:ARG42 4.1 31.0 0.4 CA A:MET43 4.1 17.2 1.0 C A:ARG42 4.2 22.7 1.0 C A:ILE37 4.4 14.8 1.0 CA A:ILE37 4.4 14.1 1.0 C A:SER38 4.4 19.1 1.0 CB A:ALA90 4.4 34.3 1.0 CG A:MET43 4.5 17.6 1.0 O A:HOH487 4.6 17.8 0.4 C A:ASP40 4.6 22.1 1.0 CB A:ASP40 4.7 27.6 1.0 CA A:ALA90 4.7 33.9 1.0 CG2 A:ILE37 4.8 16.6 1.0 O3'A A:ZZC201 4.8 26.2 1.0 O A:CYS41 4.9 23.0 0.5 C2'A A:ZZC201 4.9 28.0 1.0 CB A:MET43 5.0 17.9 1.0

Chlorine binding site 2 out of 4 in the TARG1 (C6ORF130), Terminal Adp-Ribose Glycohydrolase 1 Adp-Ribose Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of TARG1 (C6ORF130), Terminal Adp-Ribose Glycohydrolase 1 Adp-Ribose Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl203 b:36.5 occ:1.00 O B:HOH374 3.0 27.6 0.5 OG B:SER38 3.2 31.4 1.0 N B:ARG42 3.2 29.4 1.0 N B:MET43 3.3 25.0 1.0 N B:SER38 3.3 20.8 1.0 N B:CYS41 3.7 27.5 0.3 N B:CYS41 3.8 26.4 0.7 CA B:CYS41 3.8 27.3 0.3 C B:CYS41 3.9 27.9 0.7 CA B:CYS41 3.9 25.4 0.7 CB B:ILE37 3.9 19.5 1.0 C B:CYS41 3.9 28.7 0.3 CB B:SER38 4.0 28.0 1.0 CA B:ARG42 4.0 30.8 0.6 CA B:ARG42 4.1 30.8 0.5 O B:SER38 4.1 21.9 1.0 CA B:SER38 4.1 23.8 1.0 CA B:MET43 4.2 23.3 1.0 C B:ARG42 4.2 29.3 1.0 CB B:ARG42 4.2 34.4 0.6 CA B:ILE37 4.2 19.1 1.0 C B:ILE37 4.3 19.9 1.0 CB B:ARG42 4.3 34.1 0.5 CG B:MET43 4.4 20.6 1.0 C B:SER38 4.5 23.2 1.0 CG2 B:ILE37 4.6 20.8 1.0 O B:HOH374 4.6 22.1 0.5 CB B:ALA90 4.7 43.2 1.0 CB B:ASP40 4.7 35.9 1.0 C B:ASP40 4.7 27.6 1.0 O3'A B:ZZC201 4.8 33.4 0.7 O B:CYS41 4.8 29.1 0.7 CG1 B:ILE37 4.9 19.0 1.0 CB B:MET43 4.9 20.6 1.0 O3'A B:ZZC201 5.0 28.4 0.3

Chlorine binding site 3 out of 4 in the TARG1 (C6ORF130), Terminal Adp-Ribose Glycohydrolase 1 Adp-Ribose Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of TARG1 (C6ORF130), Terminal Adp-Ribose Glycohydrolase 1 Adp-Ribose Complex within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl202 b:33.7 occ:1.00 OG C:SER38 3.1 33.0 1.0 N C:ARG42 3.2 31.3 1.0 N C:MET43 3.3 25.4 1.0 N C:SER38 3.4 27.2 1.0 O C:HOH400 3.6 49.7 1.0 N C:CYS41 3.8 31.2 1.0 CB C:SER38 3.9 30.2 1.0 CB C:ILE37 4.0 23.0 1.0 C C:CYS41 4.0 31.5 1.0 CA C:ARG42 4.0 33.3 1.0 CA C:CYS41 4.0 31.3 1.0 O C:SER38 4.0 26.6 1.0 CA C:SER38 4.1 27.4 1.0 CB C:ARG42 4.1 39.2 1.0 C C:ARG42 4.2 29.2 1.0 CA C:MET43 4.2 24.2 1.0 CA C:ILE37 4.3 24.0 1.0 C C:ILE37 4.3 26.2 1.0 C C:SER38 4.4 27.5 1.0 CB C:ALA90 4.4 44.7 1.0 CG C:MET43 4.5 23.1 1.0 CB C:ASP40 4.6 37.8 1.0 C C:ASP40 4.6 32.8 1.0 CA C:ALA90 4.6 44.7 1.0 O C:HOH386 4.7 37.3 1.0 CG2 C:ILE37 4.7 23.7 1.0 CB C:MET43 5.0 23.3 1.0 CG1 C:ILE37 5.0 22.5 1.0 O3'A C:ZZC201 5.0 33.7 0.7

Chlorine binding site 4 out of 4 in the TARG1 (C6ORF130), Terminal Adp-Ribose Glycohydrolase 1 Adp-Ribose Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of TARG1 (C6ORF130), Terminal Adp-Ribose Glycohydrolase 1 Adp-Ribose Complex within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl202 b:29.2 occ:1.00 OG D:SER38 3.1 27.1 1.0 O D:HOH413 3.2 34.7 1.0 N D:ARG42 3.2 27.5 1.0 N D:SER38 3.4 22.2 1.0 N D:MET43 3.4 25.2 1.0 N D:CYS41 3.7 28.9 0.3 N D:CYS41 3.7 28.6 0.7 CB D:SER38 3.8 25.7 1.0 O D:HOH414 3.9 41.8 1.0 CA D:CYS41 3.9 28.7 0.3 C D:CYS41 3.9 28.4 0.7 CA D:CYS41 3.9 28.3 0.7 CA D:ARG42 4.0 29.9 1.0 C D:CYS41 4.0 28.4 0.3 CB D:ILE37 4.0 20.1 1.0 CB D:ARG42 4.0 36.6 1.0 CA D:SER38 4.1 23.8 1.0 O D:SER38 4.1 24.4 1.0 CB D:ALA90 4.2 33.5 1.0 C D:ARG42 4.2 26.6 1.0 CA D:MET43 4.3 23.3 1.0 CA D:ILE37 4.3 20.9 1.0 C D:ILE37 4.3 21.3 1.0 C D:SER38 4.4 24.1 1.0 CA D:ALA90 4.5 33.4 1.0 CG D:MET43 4.5 22.6 1.0 C D:ASP40 4.6 29.4 1.0 CB D:ASP40 4.6 33.5 1.0 CG2 D:ILE37 4.7 19.3 1.0 O D:CYS41 4.9 29.9 0.7 CG1 D:ILE37 5.0 20.0 1.0

R.Sharifi, R.Morra, C.D.Appel, M.Tallis, B.Chioza, G.Jankevicius, M.A.Simpson, I.Matic, E.Ozkan, B.Golia, M.J.Schellenberg, R.Weston, J.G.Williams, M.N.Rossi, H.Galehdari, J.Krahn, A.Wan, R.C.Trembath, A.H.Crosby, D.Ahel, R.Hay, A.G.Ladurner, G.Timinszky, R.S.Williams, I.Ahel. Deficiency of Terminal Adp-Ribose Protein Glycohydrolase TARG1/C6ORF130 in Neurodegenerative Disease. Embo J. V. 32 1225 2013.
ISSN: ISSN 0261-4189
PubMed: 23481255
DOI: 10.1038/EMBOJ.2013.51