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Atomistry » Chlorine » PDB 4jth-4k27 » 4jv9 » |
Chlorine in PDB 4jv9: Co-Crystal Structure of MDM2 with Inhibitor (2S,5R,6S)-2-Benzyl-5,6- Bis(4-Chlorophenyl)-4-Methylmorpholin-3-OneProtein crystallography data
The structure of Co-Crystal Structure of MDM2 with Inhibitor (2S,5R,6S)-2-Benzyl-5,6- Bis(4-Chlorophenyl)-4-Methylmorpholin-3-One, PDB code: 4jv9
was solved by
X.Huang,
F.Gonzalez-Lopez De Turiso,
D.Sun,
R.Yosup,
M.D.Bartberger,
H.P.Beck,
J.Cannon,
P.Shaffer,
J.D.Oliner,
S.H.Olson,
J.C.Medina,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Co-Crystal Structure of MDM2 with Inhibitor (2S,5R,6S)-2-Benzyl-5,6- Bis(4-Chlorophenyl)-4-Methylmorpholin-3-One
(pdb code 4jv9). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Co-Crystal Structure of MDM2 with Inhibitor (2S,5R,6S)-2-Benzyl-5,6- Bis(4-Chlorophenyl)-4-Methylmorpholin-3-One, PDB code: 4jv9: Jump to Chlorine binding site number: 1; 2; Chlorine binding site 1 out of 2 in 4jv9Go back to Chlorine Binding Sites List in 4jv9
Chlorine binding site 1 out
of 2 in the Co-Crystal Structure of MDM2 with Inhibitor (2S,5R,6S)-2-Benzyl-5,6- Bis(4-Chlorophenyl)-4-Methylmorpholin-3-One
Mono view Stereo pair view
Chlorine binding site 2 out of 2 in 4jv9Go back to Chlorine Binding Sites List in 4jv9
Chlorine binding site 2 out
of 2 in the Co-Crystal Structure of MDM2 with Inhibitor (2S,5R,6S)-2-Benzyl-5,6- Bis(4-Chlorophenyl)-4-Methylmorpholin-3-One
Mono view Stereo pair view
Reference:
F.Gonzalez-Lopez De Turiso,
D.Sun,
Y.Rew,
M.D.Bartberger,
H.P.Beck,
J.Canon,
A.Chen,
D.Chow,
T.L.Correll,
X.Huang,
L.D.Julian,
F.Kayser,
M.C.Lo,
A.M.Long,
D.Mcminn,
J.D.Oliner,
T.Osgood,
J.P.Powers,
A.Y.Saiki,
S.Schneider,
P.Shaffer,
S.H.Xiao,
P.Yakowec,
X.Yan,
Q.Ye,
D.Yu,
X.Zhao,
J.Zhou,
J.C.Medina,
S.H.Olson.
Rational Design and Binding Mode Duality of MDM2-P53 Inhibitors. J.Med.Chem. V. 56 4053 2013.
Page generated: Sat Dec 12 10:49:05 2020
ISSN: ISSN 0022-2623 PubMed: 23597064 DOI: 10.1021/JM400293Z |
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