Chlorine in PDB 4k27: Myotonic Dystrophy Type 2 Rna: Structural Studies and Designed Small Molecules That Modulate Rna Function

The structure of Myotonic Dystrophy Type 2 Rna: Structural Studies and Designed Small Molecules That Modulate Rna Function, PDB code: 4k27 was solved by H.Park, J.Lohman, M.D.Disney, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	39.73 / 2.35
Space group	P 41 21 2
Cell size a, b, c (Å), α, β, γ (°)	75.078, 75.078, 59.900, 90.00, 90.00, 90.00
R / Rfree (%)	19.4 / 24

The structure of Myotonic Dystrophy Type 2 Rna: Structural Studies and Designed Small Molecules That Modulate Rna Function also contains other interesting chemical elements:

Magnesium

(Mg)

3 atoms

The binding sites of Chlorine atom in the Myotonic Dystrophy Type 2 Rna: Structural Studies and Designed Small Molecules That Modulate Rna Function (pdb code 4k27). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 6 binding sites of Chlorine where determined in the Myotonic Dystrophy Type 2 Rna: Structural Studies and Designed Small Molecules That Modulate Rna Function, PDB code: 4k27:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6;

Chlorine binding site 1 out of 6 in the Myotonic Dystrophy Type 2 Rna: Structural Studies and Designed Small Molecules That Modulate Rna Function


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Myotonic Dystrophy Type 2 Rna: Structural Studies and Designed Small Molecules That Modulate Rna Function within 5.0Å range: probe atom residue distance (Å) B Occ U:Cl104 b:39.4 occ:1.00 O U:HOH249 3.3 28.5 1.0 O U:HOH205 3.3 26.3 1.0 N4 U:C33 3.5 17.3 1.0 C2' U:A21 3.9 17.4 1.0 O2' U:A21 3.9 17.3 1.0 O4 U:U32 4.0 17.2 1.0 O4 U:U34 4.0 17.4 1.0 C5 U:U32 4.2 17.4 1.0 C3' U:A21 4.2 17.5 1.0 O U:HOH235 4.3 16.2 1.0 C4 U:U32 4.3 21.1 1.0 C4 U:C33 4.4 17.4 1.0 C5 U:C33 4.6 17.5 1.0 O5' U:A21 4.9 17.8 1.0 O3' U:A21 5.0 17.6 1.0

Chlorine binding site 2 out of 6 in the Myotonic Dystrophy Type 2 Rna: Structural Studies and Designed Small Molecules That Modulate Rna Function


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Myotonic Dystrophy Type 2 Rna: Structural Studies and Designed Small Molecules That Modulate Rna Function within 5.0Å range: probe atom residue distance (Å) B Occ U:Cl105 b:61.2 occ:1.00 N2 U:G7 3.2 50.4 1.0 O2 U:C50 3.6 48.7 1.0 C2 U:G7 4.1 52.9 1.0 N3 U:G7 4.1 53.0 1.0 C2 U:C50 4.4 49.7 1.0 O2 U:C49 4.5 50.6 1.0 C1' U:C50 4.9 56.1 1.0 C1' U:C8 4.9 55.8 1.0

Chlorine binding site 3 out of 6 in the Myotonic Dystrophy Type 2 Rna: Structural Studies and Designed Small Molecules That Modulate Rna Function


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Myotonic Dystrophy Type 2 Rna: Structural Studies and Designed Small Molecules That Modulate Rna Function within 5.0Å range: probe atom residue distance (Å) B Occ U:Cl106 b:51.8 occ:1.00 N2 U:G15 3.5 35.6 1.0 O U:HOH252 3.6 26.2 1.0 C1' U:C42 3.9 30.7 1.0 C1' U:C16 3.9 34.1 1.0 O U:HOH243 4.1 30.0 1.0 O4' U:C42 4.2 27.6 1.0 O2' U:C42 4.2 29.7 1.0 O4' U:C16 4.3 33.2 1.0 O2 U:C42 4.3 32.8 1.0 C2 U:G15 4.5 35.3 1.0 N3 U:G15 4.5 34.4 1.0 O2 U:C16 4.5 35.9 1.0 O2' U:C16 4.6 34.3 1.0 N1 U:C16 4.7 34.5 1.0 N1 U:C42 4.7 33.4 1.0 C2' U:C42 4.7 29.2 1.0 C2 U:C42 4.8 32.5 1.0 C2 U:C16 4.9 35.4 1.0 C2' U:C16 4.9 34.7 1.0

Chlorine binding site 4 out of 6 in the Myotonic Dystrophy Type 2 Rna: Structural Studies and Designed Small Molecules That Modulate Rna Function


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Myotonic Dystrophy Type 2 Rna: Structural Studies and Designed Small Molecules That Modulate Rna Function within 5.0Å range: probe atom residue distance (Å) B Occ U:Cl107 b:62.7 occ:1.00 N2 U:G40 3.5 21.4 1.0 O U:HOH243 3.9 30.0 1.0 O U:HOH252 4.0 26.2 1.0 O2' U:C41 4.0 32.8 1.0 C1' U:C41 4.1 31.5 1.0 N3 U:G40 4.3 26.7 1.0 O4' U:C41 4.3 31.2 1.0 C2 U:G40 4.3 27.4 1.0 O U:HOH260 4.4 42.6 1.0 C2' U:C41 4.8 31.1 1.0 O2 U:C41 4.8 32.4 1.0

Chlorine binding site 5 out of 6 in the Myotonic Dystrophy Type 2 Rna: Structural Studies and Designed Small Molecules That Modulate Rna Function


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Myotonic Dystrophy Type 2 Rna: Structural Studies and Designed Small Molecules That Modulate Rna Function within 5.0Å range: probe atom residue distance (Å) B Occ U:Cl108 b:58.0 occ:1.00 N2 U:G18 3.7 19.2 1.0 C1' U:U39 3.9 21.2 1.0 C1' U:C19 3.9 22.8 1.0 O4' U:C19 4.0 23.3 1.0 O4' U:U39 4.1 21.1 1.0 O2' U:U39 4.3 22.9 1.0 O2 U:U39 4.5 20.0 1.0 O2' U:C19 4.5 19.2 1.0 O2 U:C19 4.6 18.7 1.0 N1 U:U39 4.7 20.1 1.0 C2 U:G18 4.7 19.2 1.0 N1 U:C19 4.7 21.3 1.0 N3 U:G18 4.7 22.4 1.0 C2' U:U39 4.8 21.6 1.0 C2 U:U39 4.9 24.3 1.0 C2' U:C19 4.9 21.7 1.0

Chlorine binding site 6 out of 6 in the Myotonic Dystrophy Type 2 Rna: Structural Studies and Designed Small Molecules That Modulate Rna Function


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of Myotonic Dystrophy Type 2 Rna: Structural Studies and Designed Small Molecules That Modulate Rna Function within 5.0Å range: probe atom residue distance (Å) B Occ U:Cl109 b:67.9 occ:1.00 N2 U:G44 3.5 30.5 1.0 O U:HOH241 3.5 25.9 1.0 C1' U:C13 3.9 40.2 1.0 O4' U:C13 4.1 36.3 1.0 O2 U:C13 4.3 35.2 1.0 C1' U:C45 4.3 36.4 1.0 O2' U:C13 4.4 34.4 1.0 N3 U:G44 4.4 30.4 1.0 C2 U:G44 4.4 30.9 1.0 O4' U:C45 4.6 37.1 1.0 O2 U:C45 4.6 35.1 1.0 N1 U:C13 4.7 40.5 1.0 C2' U:C13 4.8 40.7 1.0 C2 U:C13 4.8 35.8 1.0 N1 U:C45 4.9 34.5 1.0 O2 U:C12 5.0 47.3 1.0 C2 U:C45 5.0 32.5 1.0

J.Childs-Disney, I.Yildirim, H.Park, J.Lohman, L.Guan, T.Tran, P.Sarkar, G.C.Schatz, M.D.Disney. Myotonic Dystrophy Type 2 Rna: Structural Studies and Designed Small Molecules That Modulate Rna Function Acs Chem.Biol. 2013.
ISSN: ESSN 1554-8937