Chlorine in PDB 4klr: E343Q Variant of Human Ferrochelatase

All present enzymatic activity of E343Q Variant of Human Ferrochelatase:
4.99.1.1;

The structure of E343Q Variant of Human Ferrochelatase, PDB code: 4klr was solved by W.N.Lanzilotta, A.E.Medlock, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	70.71 / 2.18
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	86.127, 92.561, 109.262, 90.00, 90.00, 90.00
R / Rfree (%)	20 / 25.8

The structure of E343Q Variant of Human Ferrochelatase also contains other interesting chemical elements:

Iron

(Fe)

6 atoms

The binding sites of Chlorine atom in the E343Q Variant of Human Ferrochelatase (pdb code 4klr). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the E343Q Variant of Human Ferrochelatase, PDB code: 4klr:

Chlorine binding site 1 out of 1 in the E343Q Variant of Human Ferrochelatase


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of E343Q Variant of Human Ferrochelatase within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl506 b:77.2 occ:1.00 O A:HOH756 2.8 83.6 1.0 O A:GLN422 3.0 38.2 1.0 O A:TRP221 3.2 27.6 1.0 CB A:LYS220 3.5 34.4 1.0 CD2 A:LEU394 3.5 31.8 1.0 O A:HOH745 3.8 55.1 1.0 C A:TRP221 4.0 28.7 1.0 C A:LYS220 4.0 33.1 1.0 C A:GLN422 4.1 39.8 1.0 N A:TRP221 4.2 31.3 1.0 O A:LYS220 4.2 32.7 1.0 CB A:LEU423 4.2 47.4 1.0 CA A:LYS220 4.2 34.4 1.0 O A:HOH652 4.2 39.4 1.0 CB A:GLN421 4.3 32.4 1.0 CB A:SER222 4.5 24.5 1.0 CG A:LYS220 4.6 39.6 1.0 CD A:LYS220 4.7 47.0 1.0 CA A:TRP221 4.7 30.1 1.0 N A:SER222 4.7 27.4 1.0 CA A:LEU423 4.7 46.6 1.0 N A:LEU423 4.8 43.3 1.0 C A:LEU423 4.8 48.0 1.0 CA A:SER222 5.0 25.1 1.0 CG A:LEU394 5.0 31.7 1.0

W.N.Lanzilotta, A.E.Medlock. E343Q Variant of Human Ferrochelatase To Be Published.