Chlorine in PDB 4kvm: The Nata (NAA10P/NAA15P) Amino-Terminal Acetyltransferase Complex Bound to A Bisubstrate Analog

All present enzymatic activity of The Nata (NAA10P/NAA15P) Amino-Terminal Acetyltransferase Complex Bound to A Bisubstrate Analog:
2.3.1.88;

The structure of The Nata (NAA10P/NAA15P) Amino-Terminal Acetyltransferase Complex Bound to A Bisubstrate Analog, PDB code: 4kvm was solved by G.P.Liszczak, R.Q.Marmorstein, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	49.59 / 2.60
Space group	P 1
Cell size a, b, c (Å), α, β, γ (°)	81.439, 119.381, 134.063, 80.20, 76.60, 70.42
R / Rfree (%)	22.2 / 26

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 20; Page 3, Binding sites: 21 - 30; Page 4, Binding sites: 31 - 40; Page 5, Binding sites: 41 - 50; Page 6, Binding sites: 51 - 60; Page 7, Binding sites: 61 - 64;

Binding sites:

The binding sites of Chlorine atom in the The Nata (NAA10P/NAA15P) Amino-Terminal Acetyltransferase Complex Bound to A Bisubstrate Analog (pdb code 4kvm). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 64 binding sites of Chlorine where determined in the The Nata (NAA10P/NAA15P) Amino-Terminal Acetyltransferase Complex Bound to A Bisubstrate Analog, PDB code: 4kvm:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Chlorine binding site 1 out of 64 in the The Nata (NAA10P/NAA15P) Amino-Terminal Acetyltransferase Complex Bound to A Bisubstrate Analog


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of The Nata (NAA10P/NAA15P) Amino-Terminal Acetyltransferase Complex Bound to A Bisubstrate Analog within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl801 b:96.3 occ:1.00 O E:LEU19 3.7 61.8 1.0 NE1 A:TRP494 3.7 57.2 1.0 NH2 A:ARG448 3.9 65.4 1.0 CZ2 A:TRP494 3.9 54.3 1.0 NE A:ARG448 4.0 56.0 1.0 CE2 A:TRP494 4.2 59.4 1.0 C E:LEU19 4.2 59.5 1.0 SG A:CYS492 4.2 65.2 1.0 CZ A:ARG448 4.3 62.0 1.0 CD2 A:LEU487 4.3 57.8 1.0 N E:HIS20 4.6 46.5 1.0 CA E:HIS20 4.6 46.1 1.0 CB E:LEU19 4.8 47.0 1.0 CD1 A:TRP494 4.9 55.4 1.0

Chlorine binding site 2 out of 64 in the The Nata (NAA10P/NAA15P) Amino-Terminal Acetyltransferase Complex Bound to A Bisubstrate Analog


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of The Nata (NAA10P/NAA15P) Amino-Terminal Acetyltransferase Complex Bound to A Bisubstrate Analog within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl802 b:93.4 occ:1.00 O A:HOH922 3.6 64.2 1.0 CD1 A:PHE535 3.6 75.8 1.0 O A:PHE535 3.9 74.0 1.0 CE1 A:PHE535 4.0 77.9 1.0 CB A:PHE538 4.1 55.2 1.0 CB A:ALA147 4.3 64.7 1.0 OD1 A:ASN148 4.5 76.5 1.0 CA A:PHE535 4.5 65.5 1.0 CD2 A:PHE538 4.6 58.6 1.0 NH2 A:ARG135 4.6 64.0 1.0 CG A:PHE535 4.6 68.4 1.0 C A:PHE535 4.6 68.2 1.0 CG A:PHE538 4.8 59.5 1.0 O A:ALA147 4.9 63.1 1.0 CB A:PHE535 5.0 65.4 1.0

Chlorine binding site 3 out of 64 in the The Nata (NAA10P/NAA15P) Amino-Terminal Acetyltransferase Complex Bound to A Bisubstrate Analog


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of The Nata (NAA10P/NAA15P) Amino-Terminal Acetyltransferase Complex Bound to A Bisubstrate Analog within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl803 b:99.9 occ:1.00 CE A:LYS201 3.3 0.1 1.0 N A:ALA163 3.4 84.8 1.0 CB A:ALA163 3.6 74.2 1.0 CD A:LYS201 3.8 0.0 1.0 N A:TYR162 3.8 83.6 1.0 CA A:ALA163 4.1 87.7 1.0 O A:GLY160 4.3 0.7 1.0 C A:TYR162 4.4 88.0 1.0 CA A:TYR162 4.4 83.2 1.0 CG A:LYS201 4.4 99.5 1.0 CB A:TYR162 4.4 82.9 1.0 NZ A:LYS201 4.5 0.1 1.0 C A:GLU161 4.5 82.8 1.0 CA A:GLU161 4.7 83.6 1.0

Chlorine binding site 4 out of 64 in the The Nata (NAA10P/NAA15P) Amino-Terminal Acetyltransferase Complex Bound to A Bisubstrate Analog


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of The Nata (NAA10P/NAA15P) Amino-Terminal Acetyltransferase Complex Bound to A Bisubstrate Analog within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl804 b:0.8 occ:1.00 NZ A:LYS24 3.8 0.2 1.0 CD A:LYS24 4.9 0.6 1.0 CE A:LYS24 5.0 0.8 1.0

Chlorine binding site 5 out of 64 in the The Nata (NAA10P/NAA15P) Amino-Terminal Acetyltransferase Complex Bound to A Bisubstrate Analog


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of The Nata (NAA10P/NAA15P) Amino-Terminal Acetyltransferase Complex Bound to A Bisubstrate Analog within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl805 b:0.1 occ:1.00 NZ A:LYS129 2.4 88.6 0.3 CE A:LYS129 3.8 93.0 0.3 CL A:CL806 4.0 0.3 1.0 CD A:GLN127 4.1 73.0 1.0 CB A:ALA130 4.2 70.7 1.0 OE1 A:GLN127 4.2 73.8 1.0 NE2 A:GLN127 4.4 70.2 1.0 CG A:GLN127 4.4 67.5 1.0 CB A:GLN127 4.5 69.5 1.0 CD A:LYS129 4.6 0.6 0.3 O A:HOH932 4.6 76.9 1.0 CD A:LYS129 4.9 95.5 0.7 O A:HOH931 5.0 82.6 1.0

Chlorine binding site 6 out of 64 in the The Nata (NAA10P/NAA15P) Amino-Terminal Acetyltransferase Complex Bound to A Bisubstrate Analog


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of The Nata (NAA10P/NAA15P) Amino-Terminal Acetyltransferase Complex Bound to A Bisubstrate Analog within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl806 b:0.3 occ:1.00 CL A:CL805 4.0 0.1 1.0 NZ A:LYS99 4.0 1.0 1.0 CE A:LYS99 4.2 98.7 1.0 O A:HOH931 4.6 82.6 1.0

Chlorine binding site 7 out of 64 in the The Nata (NAA10P/NAA15P) Amino-Terminal Acetyltransferase Complex Bound to A Bisubstrate Analog


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 7 of The Nata (NAA10P/NAA15P) Amino-Terminal Acetyltransferase Complex Bound to A Bisubstrate Analog within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl807 b:0.9 occ:1.00 NH2 A:ARG159 2.7 97.1 0.4 CZ A:ARG159 3.2 88.4 0.4 NE A:ARG159 3.6 65.9 0.4 NH1 A:ARG159 3.8 84.2 0.4 CL A:CL811 4.4 0.4 1.0 NH2 A:ARG159 4.5 67.7 0.6 CD A:ARG159 4.7 70.7 0.4 CG A:LYS129 4.8 0.8 0.3 CB A:LYS129 4.9 0.9 0.3 CG A:LYS129 4.9 0.5 0.7

Chlorine binding site 8 out of 64 in the The Nata (NAA10P/NAA15P) Amino-Terminal Acetyltransferase Complex Bound to A Bisubstrate Analog


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 8 of The Nata (NAA10P/NAA15P) Amino-Terminal Acetyltransferase Complex Bound to A Bisubstrate Analog within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl808 b:0.8 occ:1.00 NZ A:LYS425 3.4 0.3 1.0 NH1 A:ARG460 4.2 87.0 1.0 O A:HOH959 4.3 0.2 1.0 NH2 A:ARG460 4.6 83.8 1.0 NZ A:LYS456 4.6 79.6 1.0 CE A:LYS425 4.8 97.3 1.0 CL A:CL810 4.8 86.6 1.0 CZ A:ARG460 4.9 83.5 1.0

Chlorine binding site 9 out of 64 in the The Nata (NAA10P/NAA15P) Amino-Terminal Acetyltransferase Complex Bound to A Bisubstrate Analog


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 9 of The Nata (NAA10P/NAA15P) Amino-Terminal Acetyltransferase Complex Bound to A Bisubstrate Analog within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl809 b:0.9 occ:1.00 NE A:ARG539 3.3 0.2 1.0 CD A:ARG539 3.3 0.5 1.0 CG A:ARG539 4.0 96.8 1.0 CZ A:ARG539 4.6 0.0 1.0 CE1 A:PHE536 4.8 62.7 1.0

Chlorine binding site 10 out of 64 in the The Nata (NAA10P/NAA15P) Amino-Terminal Acetyltransferase Complex Bound to A Bisubstrate Analog


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 10 of The Nata (NAA10P/NAA15P) Amino-Terminal Acetyltransferase Complex Bound to A Bisubstrate Analog within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl810 b:86.6 occ:1.00 NH2 A:ARG422 2.7 0.3 1.0 CZ A:ARG422 3.0 0.6 1.0 NE A:ARG422 3.3 0.9 1.0 NZ A:LYS456 3.4 79.6 1.0 NH1 A:ARG422 3.7 0.7 1.0 NZ A:LYS453 3.8 72.6 1.0 OH A:TYR457 3.9 68.7 1.0 CE2 A:TYR457 4.0 60.6 1.0 NZ A:LYS425 4.1 0.3 1.0 CE A:LYS456 4.3 75.2 1.0 CD A:ARG422 4.4 0.3 1.0 CZ A:TYR457 4.4 65.2 1.0 CE A:LYS453 4.5 75.0 1.0 CD A:LYS453 4.6 78.6 1.0 CD A:LYS456 4.7 71.7 1.0 CL A:CL808 4.8 0.8 1.0

G.Liszczak, J.M.Goldberg, H.Foyn, E.J.Petersson, T.Arnesen, R.Marmorstein. Molecular Basis For N-Terminal Acetylation By the Heterodimeric Nata Complex. Nat.Struct.Mol.Biol. V. 20 1098 2013.
ISSN: ISSN 1545-9993
PubMed: 23912279
DOI: 10.1038/NSMB.2636