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Chlorine in PDB 4lfv: Crystal Structure of Human Fpps in Complex with YS0470 and Two Molecules of Inorganic Phosphate

Enzymatic activity of Crystal Structure of Human Fpps in Complex with YS0470 and Two Molecules of Inorganic Phosphate

All present enzymatic activity of Crystal Structure of Human Fpps in Complex with YS0470 and Two Molecules of Inorganic Phosphate:
2.5.1.1; 2.5.1.10;

Protein crystallography data

The structure of Crystal Structure of Human Fpps in Complex with YS0470 and Two Molecules of Inorganic Phosphate, PDB code: 4lfv was solved by J.Park, Y.-S.Lin, Y.S.Tsantrizos, A.M.Berghuis, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 51.03 / 2.00
Space group P 41 21 2
Cell size a, b, c (Å), α, β, γ (°) 111.020, 111.020, 67.040, 90.00, 90.00, 90.00
R / Rfree (%) 17.6 / 21.8

Other elements in 4lfv:

The structure of Crystal Structure of Human Fpps in Complex with YS0470 and Two Molecules of Inorganic Phosphate also contains other interesting chemical elements:

Magnesium (Mg) 3 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Human Fpps in Complex with YS0470 and Two Molecules of Inorganic Phosphate (pdb code 4lfv). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Human Fpps in Complex with YS0470 and Two Molecules of Inorganic Phosphate, PDB code: 4lfv:

Chlorine binding site 1 out of 1 in 4lfv

Go back to Chlorine Binding Sites List in 4lfv
Chlorine binding site 1 out of 1 in the Crystal Structure of Human Fpps in Complex with YS0470 and Two Molecules of Inorganic Phosphate


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Human Fpps in Complex with YS0470 and Two Molecules of Inorganic Phosphate within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Cl407

b:48.5
occ:1.00
N F:ASP251 3.2 35.8 1.0
CB F:ASP251 3.7 46.1 1.0
CD2 F:LEU246 3.8 43.6 1.0
CA F:GLY250 3.9 34.6 1.0
C F:GLY250 4.0 36.9 1.0
CA F:ASP251 4.0 40.8 1.0
CB F:VAL254 4.1 40.0 1.0
CG1 F:VAL254 4.1 42.7 1.0
O F:ASP251 4.2 36.4 1.0
CG2 F:THR255 4.4 35.6 1.0
C F:ASP251 4.6 38.7 1.0
CG2 F:VAL254 4.7 43.8 1.0
CG F:ASP251 5.0 44.4 1.0

Reference:

J.Park, Y.S.Lin, Y.S.Tsantrizos, A.M.Berghuis. Structure of Human Farnesyl Pyrophosphate Synthase in Complex with An Aminopyridine Bisphosphonate and Two Molecules of Inorganic Phosphate. Acta Crystallogr F Struct V. 70 299 2014BIOL Commun.
ISSN: ISSN 1744-3091
PubMed: 24598914
DOI: 10.1107/S2053230X14002106
Page generated: Sat Dec 12 10:52:44 2020

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