Atomistry » Chlorine » PDB 4lbb-4lhu » 4lfx
Atomistry »
  Chlorine »
    PDB 4lbb-4lhu »
      4lfx »

Chlorine in PDB 4lfx: X-Ray Structure of the Adduct Between Hen Egg White Lysozyme and AUOXO6, A Dinuclear Gold(III) Complex with -Dioxo Bridges Linking the Two Metal Centers

Enzymatic activity of X-Ray Structure of the Adduct Between Hen Egg White Lysozyme and AUOXO6, A Dinuclear Gold(III) Complex with -Dioxo Bridges Linking the Two Metal Centers

All present enzymatic activity of X-Ray Structure of the Adduct Between Hen Egg White Lysozyme and AUOXO6, A Dinuclear Gold(III) Complex with -Dioxo Bridges Linking the Two Metal Centers:
3.2.1.17;

Protein crystallography data

The structure of X-Ray Structure of the Adduct Between Hen Egg White Lysozyme and AUOXO6, A Dinuclear Gold(III) Complex with -Dioxo Bridges Linking the Two Metal Centers, PDB code: 4lfx was solved by A.Vergara, A.Merlino, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 30.88 / 2.10
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 78.269, 78.269, 37.208, 90.00, 90.00, 90.00
R / Rfree (%) 20.4 / 28.1

Other elements in 4lfx:

The structure of X-Ray Structure of the Adduct Between Hen Egg White Lysozyme and AUOXO6, A Dinuclear Gold(III) Complex with -Dioxo Bridges Linking the Two Metal Centers also contains other interesting chemical elements:

Gold (Au) 1 atom
Sodium (Na) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the X-Ray Structure of the Adduct Between Hen Egg White Lysozyme and AUOXO6, A Dinuclear Gold(III) Complex with -Dioxo Bridges Linking the Two Metal Centers (pdb code 4lfx). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the X-Ray Structure of the Adduct Between Hen Egg White Lysozyme and AUOXO6, A Dinuclear Gold(III) Complex with -Dioxo Bridges Linking the Two Metal Centers, PDB code: 4lfx:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in 4lfx

Go back to Chlorine Binding Sites List in 4lfx
Chlorine binding site 1 out of 3 in the X-Ray Structure of the Adduct Between Hen Egg White Lysozyme and AUOXO6, A Dinuclear Gold(III) Complex with -Dioxo Bridges Linking the Two Metal Centers


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of X-Ray Structure of the Adduct Between Hen Egg White Lysozyme and AUOXO6, A Dinuclear Gold(III) Complex with -Dioxo Bridges Linking the Two Metal Centers within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl201

b:27.6
occ:1.00
 O A:HOH346 2.9 28.8 1.0
N A:THR69 3.0 25.7 1.0
O A:HOH317 3.2 28.6 1.0
N A:ARG68 3.3 24.0 1.0
O A:THR69 3.4 26.7 1.0
O A:HOH407 3.4 33.6 1.0
C A:THR69 3.5 27.1 1.0
C A:GLY67 3.5 22.3 1.0
CA A:GLY67 3.5 20.9 1.0
OG A:SER72 3.6 32.1 1.0
N A:GLY67 3.7 19.1 1.0
CA A:THR69 3.7 25.8 1.0
OD1 A:ASN65 3.9 22.8 1.0
C A:ARG68 4.0 26.4 1.0
OD1 A:ASP66 4.0 18.2 1.0
CB A:THR69 4.1 25.2 1.0
CA A:ARG68 4.1 25.7 1.0
NA A:NA203 4.2 41.0 1.0
N A:PRO70 4.3 28.1 1.0
O A:GLY67 4.3 23.1 1.0
O A:HOH403 4.6 5.2 0.5
C A:ASP66 4.8 18.7 1.0
OG1 A:THR69 4.9 21.5 1.0
CB A:SER72 4.9 30.4 1.0
N A:ASP66 4.9 16.6 1.0
CA A:PRO70 4.9 28.3 1.0

Chlorine binding site 2 out of 3 in 4lfx

Go back to Chlorine Binding Sites List in 4lfx
Chlorine binding site 2 out of 3 in the X-Ray Structure of the Adduct Between Hen Egg White Lysozyme and AUOXO6, A Dinuclear Gold(III) Complex with -Dioxo Bridges Linking the Two Metal Centers


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of X-Ray Structure of the Adduct Between Hen Egg White Lysozyme and AUOXO6, A Dinuclear Gold(III) Complex with -Dioxo Bridges Linking the Two Metal Centers within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl202

b:24.2
occ:1.00
 OH A:TYR23 2.8 17.2 1.0
O A:HOH304 3.4 11.3 1.0
CZ A:TYR23 3.6 19.6 1.0
CE2 A:TYR23 3.7 18.5 1.0
CA A:GLY104 4.1 25.2 1.0
N A:GLY104 4.7 26.0 1.0
O A:ARG21 4.8 26.2 1.0
CE1 A:TYR23 4.8 19.5 1.0
CD2 A:TYR23 4.9 18.6 1.0

Chlorine binding site 3 out of 3 in 4lfx

Go back to Chlorine Binding Sites List in 4lfx
Chlorine binding site 3 out of 3 in the X-Ray Structure of the Adduct Between Hen Egg White Lysozyme and AUOXO6, A Dinuclear Gold(III) Complex with -Dioxo Bridges Linking the Two Metal Centers


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of X-Ray Structure of the Adduct Between Hen Egg White Lysozyme and AUOXO6, A Dinuclear Gold(III) Complex with -Dioxo Bridges Linking the Two Metal Centers within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl205

b:12.0
occ:0.50
 AU A:AU204 2.6 42.5 0.5
O A:HOH338 2.6 55.7 1.0
N A:ILE88 3.6 26.6 1.0
CZ A:PHE3 3.8 18.7 1.0
O A:SER86 3.8 30.3 1.0
CA A:ASP87 3.9 27.9 1.0
CG1 A:ILE88 4.0 25.8 1.0
O A:HOH404 4.2 30.2 1.0
C A:ASP87 4.3 25.6 1.0
OD1 A:ASP87 4.3 30.8 1.0
CG2 A:ILE88 4.3 24.6 1.0
CB A:ALA11 4.3 25.6 1.0
O A:HOH368 4.3 33.9 1.0
CE2 A:PHE3 4.4 19.6 1.0
CG A:ASP87 4.5 30.7 1.0
CB A:ILE88 4.6 25.1 1.0
NH2 A:ARG14 4.6 31.3 1.0
CA A:ILE88 4.6 25.2 1.0
C A:SER86 4.7 29.8 1.0
CB A:ASP87 4.8 29.1 1.0
N A:ASP87 4.8 28.6 1.0
NE2 A:HIS15 4.9 28.9 1.0
CE1 A:PHE3 4.9 22.7 1.0

Reference:

L.Messori, F.Scaletti, L.Massai, M.A.Cinellu, C.Gabbiani, A.Vergara, A.Merlino. The Mode of Action of Anticancer Gold-Based Drugs: A Structural Perspective. Chem.Commun.(Camb.) V. 49 10100 2013.
ISSN: ISSN 1359-7345
PubMed: 24045294
DOI: 10.1039/C3CC46400H
Page generated: Fri Jul 11 18:32:38 2025

Last articles

Cl in 8AEM
Cl in 8AEC
Cl in 8ADK
Cl in 8ADJ
Cl in 8ADM
Cl in 8ACV
Cl in 8ACL
Cl in 8AD2
Cl in 8ACD
Cl in 8ACF
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy